Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Study Concerning the Safety for Heart and Brain

  • STATUS
    Recruiting
  • End date
    Jun 1, 2023
  • participants needed
    66
  • sponsor
    University Hospital, Antwerp
Updated on 25 March 2022
aneurysm
craniotomy
arrest
aneurysm clipping

Summary

Rapid ventricular pacing (RVP) is a technique to obtain flow arrest for short periods of time during dissection or rupture of the aneurysm. RVP results in an adequate fall in blood pressure which presents as an on-off phenomenon. However it is not clear whether repetitive periods of pacing are harmless for the patient. Silent cardiac and cerebral infarcts may be undetected. The investigators will study the safety of RVP, particularly for the heart and the brain.

Description

Rapid ventricular pacing (RVP) is a technique to obtain flow arrest for short periods of time during dissection or rupture of the aneurysm. RVP results in an adequate fall in blood pressure which presents as an on-off phenomenon. The technique facilitates the dissection and manipulation of cerebral aneurysms and arteriovenous malformations (AVMs) and can be lifesaving in the case of an intraoperative bleeding or rupture. In a former study blood pressure and clinical outcome were used as study parameters. However it is not clear whether repetitive periods of pacing are harmless for the patient. Silent cardiac and cerebral infarcts may be undetected if only clinical outcome is taken as a study parameter. The investigators will study the safety of RVP, particularly for the heart and the brain, using magnetic resonance imaging, brain oxygenation (Sct O₂) evaluated by near-infrared spectroscopy and troponin levels. The purpose of this study is to evaluate the effect of repetitive periods of RVP on the oxygenation of the heart and brain using magnetic resonance imaging, Sct O2 (3) and troponin levels (4) both markers for ischemia damage.

Details
Condition Cardiac Pacing, Artificial, Aneurysm, Brain, Arteriovenous Malformations, Cerebral
Treatment Rapid ventricular pacing, No rapid ventricular pacing
Clinical Study IdentifierNCT03184233
SponsorUniversity Hospital, Antwerp
Last Modified on25 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

elective cerebral aneurysm clipping surgery
arteriovenous malformation surgery
craniotomy
American Society of Anesthesiologists 1,2 and 3

Exclusion Criteria

cardiac abnormalities
coronary heart disease
valvular heart disease
pregnancy
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