SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly (SAMPHYR)

  • STATUS
    Recruiting
  • End date
    Jul 1, 2023
  • participants needed
    69
  • sponsor
    University Hospital, Caen
Updated on 30 January 2022
radical cystectomy
carcinoma
malnutrition
bladder carcinoma
grip
mass measurement

Summary

Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy.

According to EWGSOP recommendations, the diagnosis of sarcopenia is based on walking speed, grip strength and muscle mass. These three elements can easily be measured (specially muscle mass measurement by bioimpedencemetry or tomodensitometry).

This cohort study will collect clinical complementary elements to better understand the associated factors present with sarcopenia, in order to prepare an interventional preoperative physical reconditioning study.

The mobility measurement will be carried out by the QAPPA questionnaire (validated in French in the elderly) and the quantitative measurement of activity and rest hours during a week by a wrist actimeter.

Standardized geriatric data will also be collected: ADL, IADL for autonomy, MMSE for cognitive status, nutritional status (% weight loss, BMI), pain, GDS15 for depression screening, updated Charlson Comorbidity Index to identify polypathology and The STOPP tool for potentially inappropriate medication.

Post-operative morbidity mortality at 30 days will be evaluated according to Clavien-Dindo classification. Investigators will also evaluate 6 months geriatric complications : falls, loss of autonomy and decreased mobility and physical activity, cognitive degradation, undernutrition, institutionalization

Details
Condition Sarcopenia, Bladder Cancer
Treatment sarcopenia and mobility measurement
Clinical Study IdentifierNCT03362801
SponsorUniversity Hospital, Caen
Last Modified on30 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

confirmed urothelial bladder carcinoma ( RTUV)
indication of radical cystectomy
Able, informed and with informed consent for the study
affiliated to the social security system
talking French

Exclusion Criteria

Life expectancy <6 months
other active malignant tumors or other severe concomitant chronic pathologies affecting the general condition of the patient and / or likely to limit compliance with the requirements of the study
treatments incompatible with the study: previous corticosteroid treatment prolonged for more than one month (induces iatrogenic sarcopenia)
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