Last updated on February 2018

Changes in Intestinal Permeability 4 Hours After Gluten Challenge


Brief description of study

This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.

Detailed Study Description

When a person with celiac disease is exposed to gluten, their immune system attacks their bowel and causes abdominal pain, bloating, and diarrhea. This process takes 24-72 hours to occur. Some people without celiac disease develop similar symptoms when they eat gluten or wheat. Doctors and scientists do not know what causes this sensitivity to gluten. People with celiac disease and non-celiac gluten sensitivity report symptoms within hours of being exposed to gluten. This study evaluates why this occurs by looking at changes in blood, urine, stool, and the bowel after being given gluten.

Clinical Study Identifier: NCT03288831

Contact Investigators or Research Sites near you

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Carol Van Dyke, CCRP

Mayo Clinic
Rochester, MN United States
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Recruitment Status: Open


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