Last updated on November 2018

Azacitidine With or Without Nivolumab or Midostaurin or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome


Brief description of study

This randomized phase II/III trial studies how well azacitidine with or without nivolumab or midostaurin, or decitabine and cytarabine alone work in treating older patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome. Drugs used in chemotherapy, such as azacitidine, decitabine, and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as nivolumab, may interfere with the ability of cancer cells to grow and spread. Midostaurin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving azacitidine with or without nivolumab or midostaurin, or decitabine and cytarabine alone may kill more cancer cells.

Detailed Study Description

PRIMARY OBJECTIVES:

I. To select, based on overall survival, any or all of the "Novel Therapeutic" regimens for further testing against azacitidine in patients age 60 and older with newly diagnosed acute myeloid leukemia (AML) or myelodysplastic syndrome with excessive blasts-2 (MDS-EB-2). (Phase II) II. To compare overall survival of the "Novel Therapeutic" regimens selected in the phase II portion of the trial to azacitidine in these patient populations. (Phase III)

SECONDARY OBJECTIVES:

I. To estimate the frequency and severity of toxicities of the regimens in these patient populations.

II. To estimate response rates, event-free survival, and relapse-free survival for these regimens in these patient populations.

TERTIARY OBJECTIVES:

I. To investigate associations between cytogenetic and molecular abnormalities (including FLT3) and outcomes for each of the regimens in these patient populations.

II. To bank specimens for future correlative studies.

OUTLINE: Patients are randomized to 1 of 4 arms.

ARM A: Patients receive azacitidine subcutaneously (SC) or intravenously (IV) daily on days 1-7 or days 1-5 and 8-9. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive azacitidine as in Arm A and nivolumab IV over 30-60 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM C: Patients receive azacitidine as in Arm A and midostaurin orally (PO) twice daily (BID) on days 8-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM D:

INDUCTION: Patients receive decitabine IV over 2 hours on days 1-5 and cytarabine IV continuously on days 6-11. Treatment repeats every 28 days for up to 2 courses in the absence of disease progression or unacceptable toxicity.

MAINTENANCE: Patients deemed stable at the discretion of the treating physician receive decitabine as in Induction. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year, every 6 months for 2 years, then annually for 2 years.

Clinical Study Identifier: NCT03092674

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Benjamin T. Marchello

Kootenai Medical Center
Coeur d'Alene, ID United States

Benjamin T. Marchello

Kootenai Cancer Center
Post Falls, ID United States

Benjamin T. Marchello

Kootenai Cancer Clinic
Sandpoint, ID United States

Benjamin T. Marchello

Community Hospital of Anaconda
Anaconda, MT United States

Benjamin T. Marchello

Billings Clinic Cancer Center
Billings, MT United States

Benjamin T. Marchello

Bozeman Deaconess Hospital
Bozeman, MT United States

Benjamin T. Marchello

Benefis Healthcare- Sletten Cancer Institute
Great Falls, MT United States

Benjamin T. Marchello

Great Falls Clinic
Great Falls, MT United States

Benjamin T. Marchello

Saint Peter's Community Hospital
Helena, MT United States

Benjamin T. Marchello

Kalispell Regional Medical Center
Kalispell, MT United States

Benjamin T. Marchello

Community Medical Hospital
Missoula, MT United States

Benjamin T. Marchello

Billings Clinic-Cody
Cody, WY United States

Gary E. Goodman

Anchorage Associates in Radiation Medicine
Anchorage, AK United States

Gary E. Goodman

Alaska Breast Care and Surgery LLC
Anchorage, AK United States

Gary E. Goodman

Alaska Oncology and Hematology LLC
Anchorage, AK United States

Gary E. Goodman

Alaska Women's Cancer Care
Anchorage, AK United States

Gary E. Goodman

Anchorage Oncology Centre
Anchorage, AK United States

Gary E. Goodman

Katmai Oncology Group
Anchorage, AK United States

Gary E. Goodman

Providence Alaska Medical Center
Anchorage, AK United States

Mehmet S. Copur

CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, AR United States

Gary E. Goodman

Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, CA United States

Mehmet S. Copur

Penrose-Saint Francis Healthcare
Colorado Springs, CO United States

Mehmet S. Copur

Rocky Mountain Cancer Centers-Penrose
Colorado Springs, CO United States

Mehmet S. Copur

Porter Adventist Hospital
Denver, CO United States

Mehmet S. Copur

Mercy Medical Center
Durango, CO United States

Mehmet S. Copur

Southwest Oncology PC
Durango, CO United States

Mehmet S. Copur

Mountain Blue Cancer Care Center
Golden, CO United States

Mehmet S. Copur

Rocky Mountain Cancer Centers-Lakewood
Lakewood, CO United States

Mehmet S. Copur

Saint Anthony Hospital
Lakewood, CO United States

Mehmet S. Copur

Littleton Adventist Hospital
Littleton, CO United States

Mehmet S. Copur

Longmont United Hospital
Longmont, CO United States

Mehmet S. Copur

Rocky Mountain Cancer Centers-Longmont
Longmont, CO United States

Mehmet S. Copur

Parker Adventist Hospital
Parker, CO United States

Mehmet S. Copur

Rocky Mountain Cancer Centers-Parker
Parker, CO United States

Saint Mary Corwin Medical Center
Pueblo, CO United States

Mehmet S. Copur

Rocky Mountain Cancer Centers - Pueblo
Pueblo, CO United States

Mehmet S. Copur

Rocky Mountain Cancer Centers-Thornton
Thornton, CO United States

Mark R. Litzow

Mayo Clinic in Florida
Jacksonville, FL United States

Yazan Alsayed

Sacred Heart Hospital
Pensacola, FL United States

Gary E. Goodman

Saint Luke's Mountain States Tumor Institute
Boise, ID United States

Gary E. Goodman

Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, ID United States

Gary E. Goodman

Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, ID United States

Gary E. Goodman

Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, ID United States

Gary E. Goodman

Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, ID United States

Bryan A. Faller

Illinois CancerCare-Bloomington
Bloomington, IL United States

Bryan A. Faller

Illinois CancerCare-Canton
Canton, IL United States

Bryan A. Faller

Memorial Hospital of Carbondale
Carbondale, IL United States

Bryan A. Faller

SIH Cancer Institute
Carterville, IL United States

Bryan A. Faller

Illinois CancerCare-Carthage
Carthage, IL United States

Bryan A. Faller

Centralia Oncology Clinic
Centralia, IL United States

Bryan A. Faller

Decatur Memorial Hospital
Decatur, IL United States

Bryan A. Faller

Crossroads Cancer Center
Effingham, IL United States

Bryan A. Faller

Illinois CancerCare-Eureka
Eureka, IL United States

Bryan A. Faller

Illinois CancerCare-Galesburg
Galesburg, IL United States

Bryan A. Faller

Western Illinois Cancer Treatment Center
Galesburg, IL United States

Bryan A. Faller

Illinois CancerCare-Kewanee Clinic
Kewanee, IL United States

Bryan A. Faller

Illinois CancerCare-Macomb
Macomb, IL United States

Bryan A. Faller

Illinois CancerCare-Ottawa Clinic
Ottawa, IL United States

Bryan A. Faller

Illinois CancerCare-Pekin
Pekin, IL United States

Bryan A. Faller

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin, IL United States

Bryan A. Faller

Methodist Medical Center of Illinois
Peoria, IL United States

Bryan A. Faller

Illinois CancerCare-Peoria
Peoria, IL United States

Bryan A. Faller

OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, IL United States

Bryan A. Faller

OSF Saint Francis Medical Center
Peoria, IL United States

Bryan A. Faller

Illinois CancerCare-Peru
Peru, IL United States

Bryan A. Faller

Valley Radiation Oncology
Peru, IL United States

Bryan A. Faller

Illinois CancerCare-Princeton
Princeton, IL United States

Harvey E. Einhorn

SwedishAmerican Regional Cancer Center/ACT
Rockford, IL United States

Bryan A. Faller

Southern Illinois University School of Medicine
Springfield, IL United States

Bryan A. Faller

Springfield Clinic
Springfield, IL United States

Bryan A. Faller

Memorial Medical Center
Springfield, IL United States

Bryan A. Faller

Cancer Care Specialists of Illinois-Swansea
Swansea, IL United States

Mehmet S. Copur

Medical Oncology and Hematology Associates-West Des Moines
Clive, IA United States

Mehmet S. Copur

Mercy Cancer Center-West Lakes
Clive, IA United States

Mehmet S. Copur

Alegent Health Mercy Hospital
Council Bluffs, IA United States

Mehmet S. Copur

Greater Regional Medical Center
Creston, IA United States

Robert J. Behrens

Iowa Methodist Medical Center
Des Moines, IA United States

Robert J. Behrens

Medical Oncology and Hematology Associates-Des Moines
Des Moines, IA United States

Robert J. Behrens

Broadlawns Medical Center
Des Moines, IA United States

Mehmet S. Copur

Medical Oncology and Hematology Associates-Laurel
Des Moines, IA United States

Mehmet S. Copur

Mercy Medical Center - Des Moines
Des Moines, IA United States

Robert J. Behrens

Iowa Lutheran Hospital
Des Moines, IA United States

Robert J. Behrens

Methodist West Hospital
West Des Moines, IA United States

Mehmet S. Copur

Mercy Medical Center-West Lakes
West Des Moines, IA United States

Mehmet S. Copur

Flaget Memorial Hospital
Bardstown, KY United States

Mehmet S. Copur

Commonwealth Cancer Center-Corbin
Corbin, KY United States

Mehmet S. Copur

Saint Joseph Radiation Oncology Resource Center
Lexington, KY United States

Mehmet S. Copur

Saint Joseph Hospital East
Lexington, KY United States

Mehmet S. Copur

Saint Joseph London
London, KY United States

Mehmet S. Copur

Jewish Hospital
Louisville, KY United States

Mehmet S. Copur

Saints Mary and Elizabeth Hospital
Louisville, KY United States

Mehmet S. Copur

Jewish Hospital Medical Center Northeast
Louisville, KY United States

Mehmet S. Copur

Jewish Hospital Medical Center South
Shepherdsville, KY United States

Carter T. Davis

Ochsner Medical Center Jefferson
New Orleans, LA United States

Thomas H. Openshaw

Eastern Maine Medical Center
Bangor, ME United States

Thomas H. Openshaw

Lafayette Family Cancer Center-EMMC
Brewer, ME United States

Ding Wang

Henry Ford Cancer Institute Downriver
Brownstown, MI United States

Ding Wang

Henry Ford Macomb Hospital-Clinton Township
Clinton Township, MI United States

Ding Wang

Henry Ford Medical Center-Fairlane
Dearborn, MI United States

Ding Wang

Henry Ford Hospital
Detroit, MI United States

Ding Wang

Allegiance Health
Jackson, MI United States

Ding Wang

Henry Ford Medical Center-Columbus
Novi, MI United States

Ding Wang

Henry Ford West Bloomfield Hospital
West Bloomfield, MI United States

Preston D. Steen

Sanford Clinic North-Bemidgi
Bemidji, MN United States

Bret E. Friday

Essentia Health Saint Joseph's Medical Center
Brainerd, MN United States

Bret E. Friday

Essentia Health Cancer Center
Duluth, MN United States

Bret E. Friday

Essentia Health Saint Mary's Medical Center
Duluth, MN United States

Bret E. Friday

Miller-Dwan Hospital
Duluth, MN United States

Bret E. Friday

Lake Region Healthcare Corporation-Cancer Care
Fergus Falls, MN United States

Mark R. Litzow

Mayo Clinic
Rochester, MN United States

Bret E. Friday

Essentia Health Virginia Clinic
Virginia, MN United States

Bryan A. Faller

Parkland Health Center-Bonne Terre
Bonne Terre, MO United States

Bryan A. Faller

Saint Francis Medical Center
Cape Girardeau, MO United States

Bryan A. Faller

Southeast Cancer Center
Cape Girardeau, MO United States

Bryan A. Faller

Missouri Baptist Medical Center
Saint Louis, MO United States

Bryan A. Faller

Sainte Genevieve County Memorial Hospital
Sainte Genevieve, MO United States

Bryan A. Faller

Missouri Baptist Sullivan Hospital
Sullivan, MO United States

Bryan A. Faller

Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, MO United States

Gary E. Goodman

Saint Patrick Hospital - Community Hospital
Missoula, MT United States

Mehmet S. Copur

CHI Health Saint Francis
Grand Island, NE United States

Mehmet S. Copur

Heartland Hematology and Oncology
Kearney, NE United States

Mehmet S. Copur

CHI Health Good Samaritan
Kearney, NE United States

Mehmet S. Copur

Saint Elizabeth Regional Medical Center
Lincoln, NE United States

Mehmet S. Copur

Alegent Health Immanuel Medical Center
Omaha, NE United States

Mehmet S. Copur

Hematology and Oncology Consultants PC
Omaha, NE United States

Mehmet S. Copur

Alegent Health Bergan Mercy Medical Center
Omaha, NE United States

Mehmet S. Copur

Alegent Health Lakeside Hospital
Omaha, NE United States

Mehmet S. Copur

Creighton University Medical Center
Omaha, NE United States

Mehmet S. Copur

Midlands Community Hospital
Papillion, NE United States

James E. Radford

Margaret R Pardee Memorial Hospital
Hendersonville, NC United States

Preston D. Steen

Sanford Bismarck Medical Center
Bismarck, ND United States

Bret E. Friday

Essentia Health Cancer Center-South University Clinic
Fargo, ND United States

Preston D. Steen

Roger Maris Cancer Center
Fargo, ND United States

Preston D. Steen

Sanford Broadway Medical Center
Fargo, ND United States

Mehmet S. Copur

Good Samaritan Hospital - Cincinnati
Cincinnati, OH United States

Mehmet S. Copur

Bethesda North Hospital
Cincinnati, OH United States

Mehmet S. Copur

TriHealth Cancer Institute-Westside
Cincinnati, OH United States

Mehmet S. Copur

TriHealth Cancer Institute-Anderson
Cincinnati, OH United States

Adam S. Asch

University of Oklahoma Health Sciences Center
Oklahoma City, OK United States

Integris Cancer Institute of Oklahoma
Oklahoma City, OK United States

Gary E. Goodman

Saint Charles Health System
Bend, OR United States

Gary E. Goodman

Clackamas Radiation Oncology Center
Clackamas, OR United States

Gary E. Goodman

Providence Oncology and Hematology Care Southeast
Clackamas, OR United States

Gary E. Goodman

Bay Area Hospital
Coos Bay, OR United States

Gary E. Goodman

Providence Newberg Medical Center
Newberg, OR United States

Gary E. Goodman

Providence Portland Medical Center
Portland, OR United States

Gary E. Goodman

Providence Saint Vincent Medical Center
Portland, OR United States

Ikechukwu I. Akunyili

Ephrata Cancer Center
Ephrata, PA United States

Ikechukwu I. Akunyili

Ephrata Community Hospital
Ephrata, PA United States

Ikechukwu I. Akunyili

Adams Cancer Center
Gettysburg, PA United States

Ikechukwu I. Akunyili

Cherry Tree Cancer Center
Hanover, PA United States

Ikechukwu I. Akunyili

Sechler Family Cancer Center
Lebanon, PA United States

Ikechukwu I. Akunyili

WellSpan Health-York Cancer Center
York, PA United States

Ikechukwu I. Akunyili

WellSpan Health-York Hospital
York, PA United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Laurens
Clinton, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Easley
Easley, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Butternut
Greenville, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Faris
Greenville, SC United States

Jeffrey K. Giguere

Greenville Memorial Hospital
Greenville, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Eastside
Greenville, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Greer
Greer, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Seneca
Seneca, SC United States

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Spartanburg
Spartanburg, SC United States

Preston D. Steen

Sanford Cancer Center Oncology Clinic
Sioux Falls, SD United States

Preston D. Steen

Sanford USD Medical Center - Sioux Falls
Sioux Falls, SD United States

Mehmet S. Copur

Memorial Hospital
Chattanooga, TN United States

Mehmet S. Copur

Pulmonary Medicine Center of Chattanooga-Hixson
Hixson, TN United States

Mehmet S. Copur

Memorial GYN Plus
Ooltewah, TN United States

Mehmet S. Copur

Saint Joseph Regional Cancer Center
Bryan, TX United States

Gary E. Goodman

Providence Regional Cancer System-Aberdeen
Aberdeen, WA United States

Gary E. Goodman

PeaceHealth Saint Joseph Medical Center
Bellingham, WA United States

Mehmet S. Copur

Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, WA United States

Mehmet S. Copur

Harrison Medical Center
Bremerton, WA United States

Mehmet S. Copur

Highline Medical Center-Main Campus
Burien, WA United States

Gary E. Goodman

Providence Regional Cancer System-Centralia
Centralia, WA United States

Gary E. Goodman

Swedish Medical Center-Edmonds
Edmonds, WA United States

Mehmet S. Copur

Saint Elizabeth Hospital
Enumclaw, WA United States

Gary E. Goodman

Providence Regional Cancer Partnership
Everett, WA United States

Mehmet S. Copur

Saint Francis Hospital
Federal Way, WA United States

Gary E. Goodman

Swedish Cancer Institute-Issaquah
Issaquah, WA United States

Gary E. Goodman

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States

Gary E. Goodman

Providence Regional Cancer System-Lacey
Lacey, WA United States

Mehmet S. Copur

Saint Clare Hospital
Lakewood, WA United States

Gary E. Goodman

PeaceHealth Saint John Medical Center
Longview, WA United States

Mehmet S. Copur

Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, WA United States

Gary E. Goodman

Pacific Gynecology Specialists
Seattle, WA United States

Gary E. Goodman

Swedish Medical Center-Ballard Campus
Seattle, WA United States

Gary E. Goodman

Kaiser Permanente Washington
Seattle, WA United States

Gary E. Goodman

Swedish Medical Center-First Hill
Seattle, WA United States

Gary E. Goodman

Swedish Medical Center-Cherry Hill
Seattle, WA United States

Gary E. Goodman

Providence Regional Cancer System-Shelton
Shelton, WA United States

Rockwood Clinic Cancer Treatment Center-Valley
Spokane Valley, WA United States

Rockwood Cancer Treatment Center-DHEC-Downtown
Spokane, WA United States

Rockwood North Cancer Treatment Center
Spokane, WA United States

Mehmet S. Copur

Franciscan Research Center-Northwest Medical Plaza
Tacoma, WA United States

Mehmet S. Copur

Northwest Medical Specialties PLLC
Tacoma, WA United States

Gary E. Goodman

PeaceHealth Southwest Medical Center
Vancouver, WA United States

Gary E. Goodman

Providence Saint Mary Regional Cancer Center
Walla Walla, WA United States

Gary E. Goodman

Providence Regional Cancer System-Yelm
Yelm, WA United States

Maria R. Tria Tirona

Edwards Comprehensive Cancer Center
Huntington, WV United States

Bret E. Friday

Duluth Clinic Ashland
Ashland, WI United States

Mark F. Kozloff

Ingalls Memorial Hospital
Harvey, IL United States

Joseph J. Merchant

Mary Greeley Medical Center
Ames, IA United States

Joseph J. Merchant

McFarland Clinic PC-Boone
Boone, IA United States

Joseph J. Merchant

McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, IA United States

Joseph J. Merchant

McFarland Clinic PC-Jefferson
Jefferson, IA United States

Joseph J. Merchant

McFarland Clinic PC-Marshalltown
Marshalltown, IA United States

Adam S. Asch

Integris Southwest Medical Center
Oklahoma City, OK United States

Howard M. Gross

Reid Health
Richmond, IN United States

Howard M. Gross

Indu and Raj Soin Medical Center
Beavercreek, OH United States

Howard M. Gross

Dayton Physicians LLC-Miami Valley South
Centerville, OH United States

Howard M. Gross

Miami Valley Hospital South
Centerville, OH United States

Howard M. Gross

Oncology Hematology Care Inc-Kenwood
Cincinnati, OH United States

Howard M. Gross

Good Samaritan Hospital - Dayton
Dayton, OH United States

Howard M. Gross

Miami Valley Hospital
Dayton, OH United States

Howard M. Gross

Dayton Physicians LLC-Samaritan North
Dayton, OH United States

Howard M. Gross

Samaritan North Health Center
Dayton, OH United States

Howard M. Gross

Armes Family Cancer Center
Findlay, OH United States

Howard M. Gross

Blanchard Valley Hospital
Findlay, OH United States

Howard M. Gross

Orion Cancer Care
Findlay, OH United States

Howard M. Gross

Atrium Medical Center-Middletown Regional Hospital
Franklin, OH United States

Howard M. Gross

Dayton Physicians LLC-Atrium
Franklin, OH United States

Howard M. Gross

Dayton Physicians LLC-Wayne
Greenville, OH United States

Howard M. Gross

Wayne Hospital
Greenville, OH United States

Howard M. Gross

Greater Dayton Cancer Center
Kettering, OH United States

Howard M. Gross

First Dayton Cancer Care
Kettering, OH United States

Howard M. Gross

Kettering Medical Center
Kettering, OH United States

Howard M. Gross

Springfield Regional Cancer Center
Springfield, OH United States

Howard M. Gross

Springfield Regional Medical Center
Springfield, OH United States

Howard M. Gross

Dayton Physicians LLC-Upper Valley
Troy, OH United States

Howard M. Gross

Upper Valley Medical Center
Troy, OH United States

Tatjana Kolevska

Kaiser Permanente-Deer Valley Medical Center
Antioch, CA United States

Tatjana Kolevska

Kaiser Permanente-Fremont
Fremont, CA United States

Tatjana Kolevska

Fresno Cancer Center
Fresno, CA United States

Tatjana Kolevska

Kaiser Permanente-Fresno
Fresno, CA United States

Tatjana Kolevska

Kaiser Permanente-Modesto
Modesto, CA United States

Tatjana Kolevska

Kaiser Permanente Oakland-Broadway
Oakland, CA United States

Tatjana Kolevska

Kaiser Permanente-Oakland
Oakland, CA United States

Tatjana Kolevska

Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, CA United States

Tatjana Kolevska

Kaiser Permanente-Redwood City
Redwood City, CA United States

Tatjana Kolevska

Kaiser Permanente-Richmond
Richmond, CA United States

Tatjana Kolevska

Rohnert Park Cancer Center
Rohnert Park, CA United States

Tatjana Kolevska

Kaiser Permanente-Roseville
Roseville, CA United States

Tatjana Kolevska

The Permanente Medical Group-Roseville Radiation Oncology
Roseville, CA United States

Tatjana Kolevska

Kaiser Permanente-South Sacramento
Sacramento, CA United States

Tatjana Kolevska

South Sacramento Cancer Center
Sacramento, CA United States

Tatjana Kolevska

Kaiser Permanente - Sacramento
Sacramento, CA United States

Tatjana Kolevska

Kaiser Permanente-San Francisco
San Francisco, CA United States

Tatjana Kolevska

Kaiser Permanente-Santa Teresa-San Jose
San Jose, CA United States

Tatjana Kolevska

Kaiser Permanente San Leandro
San Leandro, CA United States

Tatjana Kolevska

Kaiser Permanente-San Rafael
San Rafael, CA United States

Tatjana Kolevska

Kaiser San Rafael-Gallinas
San Rafael, CA United States

Tatjana Kolevska

Kaiser Permanente Medical Center - Santa Clara
Santa Clara, CA United States

Tatjana Kolevska

Kaiser Permanente-Santa Rosa
Santa Rosa, CA United States

Tatjana Kolevska

Kaiser Permanente Cancer Treatment Center
South San Francisco, CA United States

Tatjana Kolevska

Kaiser Permanente-South San Francisco
South San Francisco, CA United States

Tatjana Kolevska

Kaiser Permanente-Stockton
Stockton, CA United States

Tatjana Kolevska

Kaiser Permanente Medical Center-Vacaville
Vacaville, CA United States

Tatjana Kolevska

Kaiser Permanente-Vallejo
Vallejo, CA United States

Tatjana Kolevska

Kaiser Permanente-Walnut Creek
Walnut Creek, CA United States

Tatjana Kolevska

Kaiser Permanente Moanalua Medical Center
Honolulu, HI United States

Lovelace Medical Center-Saint Joseph Square
Albuquerque, NM United States

Cecilia Y. Arana Yi

University of New Mexico Cancer Center
Albuquerque, NM United States

Cecilia Y. Arana Yi

Presbyterian Kaseman Hospital
Albuquerque, NM United States

Paul M. Barr

University of Rochester
Rochester, NY United States

Geoffrey L. Uy

Siteman Cancer Center at West County Hospital
Creve Coeur, MO United States

Geoffrey L. Uy

Washington University School of Medicine
Saint Louis, MO United States

Geoffrey L. Uy

Siteman Cancer Center-South County
Saint Louis, MO United States

Geoffrey L. Uy

Siteman Cancer Center at Christian Hospital
Saint Louis, MO United States

Aaron T. Gerds

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, OH United States

Aaron T. Gerds

Cleveland Clinic Foundation
Cleveland, OH United States

Aaron T. Gerds

Cleveland Clinic Cancer Center Independence
Independence, OH United States

Aaron T. Gerds

Cleveland Clinic Cancer Center Mansfield
Mansfield, OH United States

Aaron T. Gerds

Hillcrest Hospital Cancer Center
Mayfield Heights, OH United States

Aaron T. Gerds

North Coast Cancer Care
Sandusky, OH United States

Aaron T. Gerds

Cleveland Clinic Cancer Center Strongsville
Strongsville, OH United States

Aaron T. Gerds

South Pointe Hospital
Warrensville Heights, OH United States

Aaron T. Gerds

Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, OH United States

Galina Vugman

The Watson Clinic
Lakeland, FL United States

Joseph J. Merchant

McFarland Clinic PC - Ames
Ames, IA United States

David M. King

Fairview Ridges Hospital
Burnsville, MN United States

David M. King

Mercy Hospital
Coon Rapids, MN United States

David M. King

Fairview-Southdale Hospital
Edina, MN United States

David M. King

Unity Hospital
Fridley, MN United States

David M. King

Fairview Maple Grove Medical Center
Maple Grove, MN United States

David M. King

Minnesota Oncology Hematology PA-Maplewood
Maplewood, MN United States

David M. King

Abbott-Northwestern Hospital
Minneapolis, MN United States

David M. King

Hennepin County Medical Center
Minneapolis, MN United States

David M. King

Health Partners Inc
Minneapolis, MN United States

David M. King

New Ulm Medical Center
New Ulm, MN United States

David M. King

North Memorial Medical Health Center
Robbinsdale, MN United States

David M. King

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, MN United States

David M. King

Regions Hospital
Saint Paul, MN United States

David M. King

United Hospital
Saint Paul, MN United States

David M. King

Saint Francis Regional Medical Center
Shakopee, MN United States

David M. King

Lakeview Hospital
Stillwater, MN United States

David M. King

Ridgeview Medical Center
Waconia, MN United States

David M. King

Rice Memorial Hospital
Willmar, MN United States

David M. King

Minnesota Oncology Hematology PA-Woodbury
Woodbury, MN United States

David M. King

Fairview Lakes Medical Center
Wyoming, MN United States

Marc A. Rovito

Penn State Health Saint Joseph Medical Center
Reading, PA United States

David E. Marinier

Gundersen Lutheran Medical Center
La Crosse, WI United States

David M. King

Cancer Center of Western Wisconsin
New Richmond, WI United States

Alexander Menter

Kaiser Permanente-Franklin
Denver, CO United States

Keren Sturtz

SCL Health Saint Joseph Hospital
Denver, CO United States

Keren Sturtz

Good Samaritan Medical Center
Lafayette, CO United States

Alexander Menter

Kaiser Permanente-Rock Creek
Lafayette, CO United States

Alexander Menter

Kaiser Permanente-Lone Tree
Lone Tree, CO United States

Geoffrey L. Uy

Siteman Cancer Center at Saint Peters Hospital
Saint Peters, MO United States

Jay W. Carlson

Good Samaritan Regional Health Center
Mount Vernon, IL United States

Jay W. Carlson

Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, MO United States

Jay W. Carlson

Cox Cancer Center Branson
Branson, MO United States

Bryan A. Faller

Capital Region Southwest Campus
Jefferson City, MO United States

Jay W. Carlson

Freeman Health System
Joplin, MO United States

Jay W. Carlson

Mercy Hospital Joplin
Joplin, MO United States

Jay W. Carlson

Delbert Day Cancer Institute at PCRMC
Rolla, MO United States

Jay W. Carlson

Mercy Clinic-Rolla-Cancer and Hematology
Rolla, MO United States

Jay W. Carlson

Heartland Regional Medical Center
Saint Joseph, MO United States

Jay W. Carlson

Saint Louis Cancer and Breast Institute-South City
Saint Louis, MO United States

Jay W. Carlson

Mercy Hospital Saint Louis
Saint Louis, MO United States

Jay W. Carlson

Mercy Hospital Springfield
Springfield, MO United States

Jay W. Carlson

CoxHealth South Hospital
Springfield, MO United States

Jay W. Carlson

Mercy Hospital Washington
Washington, MO United States

Jay W. Carlson

Mercy Hospital Oklahoma City
Oklahoma City, OK United States

Kiran K. Yalamanchili

Covenant Medical Center-Lakeside
Lubbock, TX United States

Peter Rubin

Harold Alfond Center for Cancer Care
Augusta, ME United States

Peter Rubin

Waldo County General Hospital
Belfast, ME United States

Peter Rubin

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford, ME United States

Peter Rubin

Penobscot Bay Medical Center
Rockport, ME United States

Peter Rubin

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, ME United States

Jay Yang

Wayne State University/Karmanos Cancer Institute
Detroit, MI United States

Jay Yang

Weisberg Cancer Treatment Center
Farmington Hills, MI United States

Kendra L. Sweet

Moffitt Cancer Center
Tampa, FL United States

Tareq Al Baghdadi

Saint Alphonsus Cancer Care Center-Boise
Boise, ID United States

Tareq Al Baghdadi

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, ID United States

Tareq Al Baghdadi

Walter Knox Memorial Hospital
Emmett, ID United States

Tareq Al Baghdadi

Idaho Urologic Institute-Meridian
Meridian, ID United States

Tareq Al Baghdadi

Saint Alphonsus Medical Center-Nampa
Nampa, ID United States

Larry D. Cripe

Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, IN United States

Larry D. Cripe

Sidney and Lois Eskenazi Hospital
Indianapolis, IN United States

Tareq Al Baghdadi

Saint Joseph Mercy Hospital
Ann Arbor, MI United States

Tareq Al Baghdadi

IHA Hematology Oncology Consultants-Brighton
Brighton, MI United States

Tareq Al Baghdadi

Saint Joseph Mercy Brighton
Brighton, MI United States

Tareq Al Baghdadi

IHA Hematology Oncology Consultants-Canton
Canton, MI United States

Tareq Al Baghdadi

Saint Joseph Mercy Canton
Canton, MI United States

Tareq Al Baghdadi

Caro Cancer Center
Caro, MI United States

Tareq Al Baghdadi

IHA Hematology Oncology Consultants-Chelsea
Chelsea, MI United States

Tareq Al Baghdadi

Saint Joseph Mercy Chelsea
Chelsea, MI United States

Tareq Al Baghdadi

Hematology Oncology Consultants-Clarkston
Clarkston, MI United States

Tareq Al Baghdadi

Newland Medical Associates-Clarkston
Clarkston, MI United States

Tareq Al Baghdadi

Great Lakes Cancer Management Specialists-Doctors Park
East China Township, MI United States

Tareq Al Baghdadi

Genesee Cancer and Blood Disease Treatment Center
Flint, MI United States

Tareq Al Baghdadi

Genesee Hematology Oncology PC
Flint, MI United States

Tareq Al Baghdadi

Genesys Hurley Cancer Institute
Flint, MI United States

Tareq Al Baghdadi

Hurley Medical Center
Flint, MI United States

Tareq Al Baghdadi

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, MI United States

Tareq Al Baghdadi

Lymphoma Clinic of Michigan
Grosse Pointe Woods, MI United States

Tareq Al Baghdadi

Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods, MI United States

Tareq Al Baghdadi

Sparrow Hospital
Lansing, MI United States

Tareq Al Baghdadi

Hope Cancer Clinic
Livonia, MI United States

Tareq Al Baghdadi

Saint Mary Mercy Hospital
Livonia, MI United States

Tareq Al Baghdadi

Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, MI United States

Tareq Al Baghdadi

Michigan Breast Specialists-Macomb Township
Macomb, MI United States

Tareq Al Baghdadi

Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, MI United States

Tareq Al Baghdadi

21st Century Oncology-Pontiac
Pontiac, MI United States

Tareq Al Baghdadi

Hope Cancer Center
Pontiac, MI United States

Tareq Al Baghdadi

Newland Medical Associates-Pontiac
Pontiac, MI United States

Tareq Al Baghdadi

Saint Joseph Mercy Oakland
Pontiac, MI United States

Tareq Al Baghdadi

Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills, MI United States

Tareq Al Baghdadi

Saint Mary's of Michigan
Saginaw, MI United States

Tareq Al Baghdadi

Oncology Hematology Associates of Saginaw Valley PC
Saginaw, MI United States

Tareq Al Baghdadi

Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, MI United States

Tareq Al Baghdadi

Saint Joseph Health System-Tawas City
Tawas City, MI United States

Tareq Al Baghdadi

Advanced Breast Care Center PLLC
Warren, MI United States

Tareq Al Baghdadi

Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, MI United States

Tareq Al Baghdadi

Macomb Hematology Oncology PC
Warren, MI United States

Tareq Al Baghdadi

Michigan Breast Specialists-Warren
Warren, MI United States

Tareq Al Baghdadi

Saint John Macomb-Oakland Hospital
Warren, MI United States

Tareq Al Baghdadi

Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, MI United States

Tareq Al Baghdadi

Huron Gastroenterology PC
Ypsilanti, MI United States

Tareq Al Baghdadi

IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, MI United States

Tareq Al Baghdadi

Saint Alphonsus Medical Center-Baker City
Baker City, OR United States

Tareq Al Baghdadi

Saint Alphonsus Medical Center-Ontario
Ontario, OR United States

Tareq Al Baghdadi

Lehigh Valley Hospital-Cedar Crest
Allentown, PA United States

Tareq Al Baghdadi

Lehigh Valley Hospital - Muhlenberg
Bethlehem, PA United States

Tareq Al Baghdadi

Pocono Medical Center
East Stroudsburg, PA United States

Tareq Al Baghdadi

Lehigh Valley Hospital-Hazleton
Hazleton, PA United States

Andrew W. Pippas

John B Amos Cancer Center
Columbus, GA United States

Gary E. Goodman

Saint Charles Health System-Redmond
Redmond, OR United States

Danielle A. Shafer

Virginia Commonwealth University/Massey Cancer Center
Richmond, VA United States

Gary E. Goodman

PeaceHealth United General Medical Center
Sedro-Woolley, WA United States

Mohamad Cherry

Morristown Medical Center
Morristown, NJ United States

Mohamad Cherry

Overlook Hospital
Summit, NJ United States

Selina M. Luger

University of Pennsylvania/Abramson Cancer Center
Philadelphia, PA United States

Kathleen W. Phelan

Loyola University Medical Center
Maywood, IL United States

Kathleen W. Phelan

Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, IL United States

Rakesh Gaur

Central Care Cancer Center - Garden City
Garden City, KS United States

Rakesh Gaur

Central Care Cancer Center - Great Bend
Great Bend, KS United States

Rakesh Gaur

Kansas Institute of Medicine Cancer and Blood Center
Lenexa, KS United States

Rakesh Gaur

Minimally Invasive Surgery Hospital
Lenexa, KS United States

Rakesh Gaur

Menorah Medical Center
Overland Park, KS United States

Rakesh Gaur

Central Care Cancer Center - Bolivar
Bolivar, MO United States

Rakesh Gaur

Centerpoint Medical Center LLC
Independence, MO United States

Rakesh Gaur

Research Medical Center
Kansas City, MO United States

Priyank P. Patel

Rush - Copley Medical Center
Aurora, IL United States

Priyank P. Patel

Carle on Vermilion
Danville, IL United States

Priyank P. Patel

Carle Physician Group-Effingham
Effingham, IL United States

Priyank P. Patel

Carle Physician Group-Mattoon/Charleston
Mattoon, IL United States

Priyank P. Patel

Carle Cancer Center
Urbana, IL United States

Priyank P. Patel

The Carle Foundation Hospital
Urbana, IL United States

Priyank P. Patel

Rush-Copley Healthcare Center
Yorkville, IL United States

Bret E. Friday

Essentia Health Hibbing Clinic
Hibbing, MN United States

Benjamin T. Marchello

Welch Cancer Center
Sheridan, WY United States

Tatjana Kolevska

Kaiser Permanente Downtown Commons
Sacramento, CA United States

Darla K. Liles

East Carolina University
Greenville, NC United States

Steven E. Coutre

Stanford Cancer Institute Palo Alto
Palo Alto, CA United States

Steven E. Coutre

Stanford Cancer Center South Bay
San Jose, CA United States

Gregory A. Masters

Beebe Medical Center
Lewes, DE United States

Gregory A. Masters

Delaware Clinical and Laboratory Physicians PA
Newark, DE United States

Gregory A. Masters

Helen F Graham Cancer Center
Newark, DE United States

Gregory A. Masters

Medical Oncology Hematology Consultants PA
Newark, DE United States

Gregory A. Masters

Regional Hematology and Oncology PA
Newark, DE United States

Gregory A. Masters

Christiana Care Health System-Christiana Hospital
Newark, DE United States

Gregory A. Masters

Beebe Health Campus
Rehoboth Beach, DE United States

Gregory A. Masters

Nanticoke Memorial Hospital
Seaford, DE United States

Gregory A. Masters

Christiana Care Health System-Wilmington Hospital
Wilmington, DE United States

Robert J. Behrens

Trinity Regional Medical Center
Fort Dodge, IA United States

Gregory A. Masters

Christiana Care Health System-Concord Health Center
Chadds Ford, PA United States

Sameem M. Abedin

Froedtert and the Medical College of Wisconsin
Milwaukee, WI United States

Bryan A. Faller

Cancer Care Specialists of Illinois - Decatur
Decatur, IL United States

Bryan A. Faller

Southwest Illinois Health Services LLP
Swansea, IL United States

Robert F. Manges

Parkview Hospital Randallia
Fort Wayne, IN United States

Bret E. Friday

Essentia Health - Deer River Clinic
Deer River, MN United States

Bret E. Friday

Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, MN United States

Bret E. Friday

Essentia Health - Fosston
Fosston, MN United States

Bret E. Friday

Essentia Health - Park Rapids
Park Rapids, MN United States

Bret E. Friday

Essentia Health Sandstone
Sandstone, MN United States

Cecilia Y. Arana Yi

New Mexico Oncology Hematology Consultants
Albuquerque, NM United States

Bret E. Friday

Essentia Health - Jamestown Clinic
Jamestown, ND United States

Bret E. Friday

Ashland Memorial Medical Center
Ashland, WI United States

Brian A. Jonas

Fremont - Rideout Cancer Center
Marysville, CA United States

Brian A. Jonas

University of California Davis Comprehensive Cancer Center
Sacramento, CA United States

Brian A. Jonas

Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, CA United States

Kathleen W. Phelan

Hines Veterans Administration Hospital
Hines, IL United States

Preston D. Steen

Sanford Thief River Falls Medical Center
Thief River Falls, MN United States

Preston D. Steen

Sanford South University Medical Center
Fargo, ND United States

David M. King

Saint John's Hospital - Healtheast
Maplewood, MN United States

Preston D. Steen

Sanford Cancer Center Worthington
Worthington, MN United States

Rangaswamy Govindarajan

Veteran's Administration Medical Center
Little Rock, AR United States

Salil Goorha

Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, MS United States

Salil Goorha

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, MS United States

Salil Goorha

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, TN United States

Ryan J. Mattison

University of Wisconsin Hospital and Clinics
Madison, WI United States

Shaker R. Dakhil

Lawrence Memorial Hospital
Lawrence, KS United States

Shaker R. Dakhil

Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, KS United States

Shaker R. Dakhil

Cancer Center of Kansas - Wichita
Wichita, KS United States

Shaker R. Dakhil

Via Christi Regional Medical Center
Wichita, KS United States

Shaker R. Dakhil

Wesley Medical Center
Wichita, KS United States

Tareq Al Baghdadi

Ascension Saint John Hospital
Detroit, MI United States

Abington Memorial Hospital
Abington, PA United States

Willard G. Andrews

Abington Memorial Hospital-Asplundh Cancer Pavilion
Willow Grove, PA United States

Keri Maher

University of Arizona Cancer Center-Orange Grove Campus
Tucson, AZ United States

Keri Maher

University of Arizona Cancer Center-North Campus
Tucson, AZ United States

Keri Maher

The University of Arizona Medical Center-University Campus
Tucson, AZ United States

Tareq Al Baghdadi

Mercy Medical Center
Springfield, MA United States

Matthew L. Ryan

Green Bay Oncology - Escanaba
Escanaba, MI United States

Annie P. Im

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, PA United States

Matthew L. Ryan

Saint Vincent Hospital Cancer Center Green Bay
Green Bay, WI United States

Matthew L. Ryan

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, WI United States

Matthew L. Ryan

Holy Family Memorial Hospital
Manitowoc, WI United States

Matthew L. Ryan

Saint Vincent Hospital Cancer Center at Marinette
Marinette, WI United States

Matthew L. Ryan

Green Bay Oncology - Oconto Falls
Oconto Falls, WI United States

Matthew L. Ryan

HSHS Saint Nicholas Hospital
Sheboygan, WI United States

Matthew L. Ryan

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, WI United States

Steven R. Schuster

University of Colorado Hospital
Aurora, CO United States

Steven R. Schuster

Poudre Valley Hospital
Fort Collins, CO United States

David M. King

Monticello Cancer Center
Monticello, MN United States

Cecilia Y. Arana Yi

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, NM United States

Keren Sturtz

Rocky Mountain Cancer Centers-Aurora
Aurora, CO United States

Keren Sturtz

Boulder Community Hospital
Boulder, CO United States

Keren Sturtz

Rocky Mountain Cancer Centers-Boulder
Boulder, CO United States

Keren Sturtz

Denver Health Medical Center
Denver, CO United States

Keren Sturtz

National Jewish Health-Main Campus
Denver, CO United States

Keren Sturtz

The Women's Imaging Center
Denver, CO United States

Keren Sturtz

Colorado Blood Cancer Institute
Denver, CO United States

Keren Sturtz

Presbyterian - Saint Lukes Medical Center - Health One
Denver, CO United States

Keren Sturtz

Rocky Mountain Cancer Centers-Midtown
Denver, CO United States

Keren Sturtz

Rocky Mountain Cancer Centers-Rose
Denver, CO United States

Keren Sturtz

Western Surgical Care
Denver, CO United States

Keren Sturtz

Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood, CO United States

Keren Sturtz

Swedish Medical Center
Englewood, CO United States

Keren Sturtz

National Jewish Health-Western Hematology Oncology
Golden, CO United States

Keren Sturtz

Saint Mary's Hospital and Regional Medical Center
Grand Junction, CO United States

Keren Sturtz

North Colorado Medical Center
Greeley, CO United States

Keren Sturtz

Rocky Mountain Cancer Centers-Littleton
Littleton, CO United States

Keren Sturtz

Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, CO United States

Keren Sturtz

McKee Medical Center
Loveland, CO United States

Keren Sturtz

National Jewish Health-Northern Hematology Oncology
Thornton, CO United States

Keren Sturtz

SCL Health Lutheran Medical Center
Wheat Ridge, CO United States

Jeffrey P. Letzer

Mid-Michigan Medical Center - Midland
Midland, MI United States

Keren Sturtz

Saint Vincent Healthcare
Billings, MT United States

Keren Sturtz

Saint Vincent Frontier Cancer Center
Billings, MT United States

Keren Sturtz

Saint James Community Hospital and Cancer Treatment Center
Butte, MT United States

Dan Costin

Dickstein Cancer Treatment Center
White Plains, NY United States

Keren Sturtz

Cheyenne Regional Medical Center-West
Cheyenne, WY United States

Syed S. Ali

Baystate Medical Center
Springfield, MA United States