Last updated on December 2017

Do you take opioids to treat your chronic pain?

Brief description of study

Researchers at the MGH Center for Translational Pain Research are seeking participants for a 4-week study on chronic pain management. 

The purpose of this study is to determine whether the study drug, guanfacine, in combination with an opioid medication can help reduce pain and reverse the indications of opioid-induced hyperalgesia (OIH) in chronic pain patients. Sometimes long-term opioid therapy leads to an increased sensitivity to pain, this condition is known as OIH. 

Detailed Study Description

The study will consist of 4 office visits and 2 phone calls. Participants will be randomly assigned to receive either guanfacine or placebo. Participants will be asked to provide one blood sample, multiple urine samples for drug screen analysis, fill out questionnaires, and undergo sensitivity tests to hot and cold temperatures using an FDA approved machine. Participants will be compensated up to $190 upon completion of the study.

If you are interested in hearing more about this study, please contact Olivia:


Clinical Study Identifier: TX154673

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MGH Center for Translational Pain Research

101 Merrimac Street Suite 610 Boston, MA United States
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