LUX-Lung IO: A phase II, open label, non-randomised study ofafatinib in combination with pembrolizumab in patients withlocally advanced or metastatic squamous cell carcinoma of thelung

    Not Recruiting
  • sponsor
    Boehringer Ingelheim
Updated on 7 May 2021
squamous cell carcinoma
lung cancer
chemotherapy regimen
platinum-based chemotherapy
metastatic squamous cell carcinoma
lung carcinoma


LUX-Lung IO: A phase II, open label, non-randomised study of afatinib in combination with pembrolizumab in patients with locally advanced or metastatic squamous cell carcinoma of the lung


This trial is an open-label, single arm phase II study assessing the tolerability and anti-tumour activity of afatinib when given in combination with a fixed dose of pembrolizumab in patients with squamous NSCLC, who progressed during or after first line platinum-based standard therapy and had no prior treatment with an immune checkpoint inhibitor or EGFR targeted therapy.
The patient’s condition may or may not improve if the patient joins this study. The patient may benefit from the patient’s tumor shrinking more and having a longer time before the tumor begins to grow again, but none of these benefits can be promised. The results of this study may help other people with the same condition in the future.

Condition Squamous cell carcinoma, Lung Cancer
Clinical Study IdentifierTX153056
SponsorBoehringer Ingelheim
Last Modified on7 May 2021

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