Mild and Rapidly Improving Stroke Study MaRISS

  • sponsor
    American Heart Association
Updated on 25 March 2021


Mild and Rapidly Improving Stroke Study MaRISS


MaRISS is a prospective observational study to define the 90-day outcomes of patients with mild and/or rapidly improving stroke by a telephone-based assessment of stroke outcomes based on established and validated measures including the mRS, BI, SIS-16 and EuroQOL. The efficacy and safety outcomes of patients with mild and improving strokes treated with thrombolytics will be explored by comparing them to those treated conservatively without thrombolytics.

Please contact Candida Barlow, Director, St. John Clinical Research Institute
1725 E. 19th St. Suite 701
Tulsa, OK 74104
Office: 918-744-3426 Fax: 918-403-0018

Condition *Healthy Children Studies
Clinical Study IdentifierTX151544
SponsorAmerican Heart Association
Last Modified on25 March 2021


Yes No Not Sure

Inclusion Criteria

Patients with mild or spontaneously rapidly improving acute ischemic stroke defined clinically. Mild stroke is defined as an NIHSS 0-5. MaRISS does not define Rapidly Improving Stroke Symptoms for purposes of enrollment. It enrolls patients after the determination to treat or not to treat has been made, in order not to influence treatment decisions
Absence of non-ischemic conditions on neuro-imaging (i.e. absence of hemorrhage or a mass on non-contrast brain CT, or more advanced imaging obtained according to participating site’s imaging protocol)
Age 18 years or older
Arrival to the hospital within 4.5 hours after the onset of stroke symptoms
Patient or legally authorized representative provides consent within 24 hours of arrival. Obtaining consent beyond 24h will be allowed if the patient arrived to the hospital within 4.5 hours of the onset of symptoms and the NIHSS is performed as standard of care at 24 hours +/- 4 hours from onset of symptoms (or before if the patient has neurological deterioration) by a certified practitioner and provided that the NIHSS sub-scores information is readily available and can be recorded in the participant’s study record
Available by telephone and willing to receive two follow-up telephone calls over the next 3 months

Exclusion Criteria

Acute stroke patients arriving to the hospital beyond 4.5 hours from symptom onset
Unable to obtain consent from either patient or legally authorized representative
Pre-morbid modified Rankin scale greater than 1
Not available by telephone
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note