Last updated on June 2018

GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease


Brief description of study

GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

Detailed Study Description

The purpose of this study is to evaluate itacitinib or placebo in combination with corticosteroids as first-line treatment of participants with Grade II to IV acute graft-versus-host disease (aGVHD).

Clinical Study Identifier: TX151481

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University of California, Los Angeles (UCLA) - Medical Center
Los Angeles, CA United States
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University of Florida (UF) - Division of Hematology & Oncology
Gainesville, FL United States
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Indiana Blood and Marrow Transplant
Indianapolis, IN United States
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University of Iowa
Iowa City, IA United States
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Tufts Medical Center
Boston, MA United States
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Barbara Ann Karmanos Cancer Institute
Detroit, MI United States
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Washington University School of Medicine
Saint Louis, MO United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, NJ United States
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Columbia University
New York, NY USA
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Thomas Jefferson University
Philadelphia, PA United States
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Hospital Universitario Vall d'Hebron
Barcelona, Spain
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Hospital Universitario Ramon y Cajal
Madrid, Spain
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Hospital Universitario La Paz
Madrid, Spain
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University of Kansas Cancer Center

University of Kansas Cancer Center
Kansas City, KS United States
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Hackensack University Medical Center

Hackensack University Medical Center
Hackensack, NJ USA
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Ordensklinikum Linz GmbH Elisabethinen

Ordensklinikum Linz GmbH Elisabethinen
Linz, Austria
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Centrum Onkologii- Instytut w Gliwicach

Centrum Onkologii- Instytut w Gliwicach
Gliwice, Poland
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City of Hope National Medical Center
Duarte, CA USA
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University of Virginia Cancer Center
Charlottesville, VA USA
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University Hospital of Donostia
San Sebastian (Guipuzcoa), XX ESP
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Hospital Universitario Marques de Valdecilla
Santander, XX ESP
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Medical University Graz
Graz, XX Austria
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Ospedale Dell'angelo - U.O. Ematologia
Mestre, XX Italy
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Klinika Transplantacji Komorek Krwiotworczych IHiT
Warszawa, XX Poland
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Cancer Care Manitoba
Winnipeg, Manitoba CAN
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Icon Cancer Care
Auchenflower, XX Australia
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General Hospital Sint-Jan Brugge-Oostend
Brugge, XX Belgium
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Universitair Ziekenhuis Gent (UZ)
Gent, XX Belgium
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Hôpital universitaire du Sart Tilman de Liège
Liège, XX Belgium
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ZNA Stuivenberg
Antwerpen, XX Belgium
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Hopital Saint Louis
Paris, XX France
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Universitaetsklinikum Giessen und Marburg GmbH - Klinik fuer Innere Medizin
Marburg, XX Germany
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Universitätsklinikum Freiburg - Klinik für Innere Medizin I
Freiburg, XX Germany
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Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden
Dresden, XX Germany
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IRCCS Ospedale San Raffaele
Milan, XX Italy
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Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
Bergamo, XX Italy
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano
Milan, XX Italy
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Wellington Regional Hospital
Wellington, XX New Zealand
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Instituto Catalan de Oncologia - Hospital Duran i Reynals
Barcelona, XX Spain
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Hospital General Universitario Gregorio Maranon
Madrid, XX Spain
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Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda Madrid, XX Spain
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Hospital Clinico de Santiago de Compostela
Santiago de Compostelaompostela, XX Spain
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Hospital Universitari i Politecnic La Fe
Valencia, XX Spain
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Universtity Hospital Basel - Haematology
Basel, XX Switzerland
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Hopitaux Universitaires de Geneve
Geneve, XX Switzerland
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University of Southern California
Los Angeles, CA USA
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Rush University Medical Center
Chicago, IL USA
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Indiana University (IU) Melvin and Bren Simon Cancer Center
Indianapolis, IN USA
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University of Maryland
Baltimore, MD USA
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The Ohio State University (OSU)
Columbus, OH USA
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University of Oklahoma - Health Sciences Center
Oklahoma City, OK USA
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Oregon Health & Science University (OHSU)
Portland, OR United States
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Jessa Ziekenhuis, Campus Virga Jesse
Hasselt, Belgium
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Cliniques Universitaires Saint-Luc
Brussels, Belgium
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UHKT Praha
Praha 2, Czech Republic
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Hotel Dieu Hospital - Hematologie
Nantes Cedex 1, France
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CHU Vandoeuvre les Nancy
Vandoeuvre-les-Nancy Cedex, France
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Hopital Claude Huriez - CHU Lille
Lille Cedex, France
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Institut Claudius Regaud-Oncopole
Toulouse Cedex 9, France
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CHU Amiens Picardie - Hopital Sud
Amiens (anciennement Salouel), France
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CHRU de Strasbourg - Hôpital de Hautepierre
Strasbourg Cedex, France
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Helsinki University Central Hospital
Helsinki, Finland
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Universitaetsklinikum Leipzig
Leipzig, Germany
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University Medical Center Hamburg-Eppendorf
Hamburg, Germany
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Hospital G. Papanikolaou Hematology Dept
Exohi Thessaloniki, Greece
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Del-pesti Centrkorhaz Orsz Hemat es Infekt Intezet
Budapest, Hungary
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Rambam Health Care Campus
Haifa, Israel
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Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
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Chaim Sheba Medical Center
Ramat Gan, Israel
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Presidio Ospedaliero Pescara
Pescara, Italy
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AO Bianchi-Melacrino-Morelli Reggio Calabria
Reggio Calabria RC, Italy
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AOUP V Emanuele - Ospedale Ferrarotto Alessi
Catania, Italy
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Casa di Cura La Maddalena
Palermo, Italy
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Istituto Clinico Humanitas
Rozzano, Italy
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IPO Porto
Porto, Portugal
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Seoul National University Hospital
Seoul, South Korea
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Hospital Clinic i Provincial de Barcelona
Barcelona, Spain
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Universitaetsspital Zuerich - Klinik fuer Haematology
Zurich, Switzerland
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University of Illinois at Chicago
Chicago, IL USA
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Levine Cancer Institute
Charlotte, NC USA
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Wake Forest Baptist Health
Winston-Salem, NC USA
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Dartmouth Hitchcock Medical Center
Lebanon, NH USA
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Medizinische Universität Wien, Knochenmarktransplantation
Wien, Austria
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Hôpital Haut Lévèque - CHU Bordeaux - Maladies du sang
PESSAC, France
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Centre Hospitalier Lyon Sud
Pierre Bénite Cedex, France
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Universitatsklinikum Koln
Koln, Germany
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University General Hospital of Patras
Patras, Greece
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General Hospital of Thessaloniki G. Papanikolaou - Hematology Department, BMT Unit
Thessaloniki, Greece
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Hadassah Hebrew University Medical Center Ein Karem
Jerusalem, Israel
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Pusan National University Hospital
Busan-si, South Korea
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Royal Marsden Hospital - Surrey
Surrey, United Kingdom
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The Christie Hospital NHS Trust
Withington, Manchester United Kingdom
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Addenbrooke’s Hospital
Cambridge, United Kingdom
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University of Massachusetts Memorial Medical Center
Worcester, MA USA
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Mayo Clinic - Rochester
Rochester, MN USA
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Levine Cancer Institute
Charlotte, NC USA
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