Last updated on July 2016

Adolescents with Depression and/or Anxiety and a Parent or Sibling with Bipolar Disorder


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Bipolar Disorder | Attention Deficit/Hyperactivity Disorder (ADHD - Pediatric) | Bipolar Disorders (Pediatric)
  • Age: Between 12 - 17 Years
  • Gender: Male or Female

Eligibility Criteria:

Adolescents 12 to 17 years of age who are experiencing depressive and/or anxiety symptoms or have been diagnosed with depression and.or anxiety and have a first-degree relative (parent or sibling) with bipolar I disorder may be eligible to participate.

Inclusion Criteria:

Inclusion - High-Risk Youth:

  1. age 12 years, 0 mos. - 17 years, 11 mos.;
  2. at least one parent or step-parent/guardian with whom the subject lives is willing to participate in research sessions;
  3. the child and relative(s) are able and willing to give written informed assent/consent to participate, respectively;
  4. the youth meets criteria for high-risk:
    • has at least one first degree relative with Bipolar I Disorder, as assessed by the Structured Clinical Interview for DSM (SCID; First et al. 1995), the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS-PL, Kaufman et al., 1997), and the Family History-Research Diagnostic Criteria (FH-RDC; Andreasen et al., 1977);
    • the youth shows evidence of current significant depressive or anxiety symptoms as determined by a current Childhood Depression Rating Scale-Revised (CDRS-R, Poznanski et al.,1984) score > 35 and/or a current Pediatric Anxiety Rating Scale (PARS, 2002) score > 15.

Inclusion - Healthy Controls:

  1. age 12 years, 0 mos. - 17 years, 11 mos.;
  2. at least one parent or step-parent/guardian with whom the subject lives is willing to participate in research sessions;
  3. the child and relative(s) are able and willing to give written informed assent/consent to participate, respectively;
  4. no personal or family history of any psychopathology as assessed by the KSADS-PL structured clinical interview (Kaufman et al., 1997) and the Family History-Research Diagnostic Criteria (FH-RDC; Andreasen et al., 1977).

Exclusion Criteria:

Exclusion - High-Risk Youth & Healthy Controls:

  1. any history of syndromal bipolar I or II disorder (i.e., history of mania, mixed episode, or major depression with hypomania);
  2. a history of previous antidepressant exposure
  3. a DSM-5 diagnosis of autism, pervasive developmental disorder, OCD(Obsessive-Compulsive Disorder), PTSD, Tourette's disorder, or any psychotic disorder including schizophrenia;
  4. evidence of mental retardation (IQ < 70) as determined by the Weschler Abbreviated Scale of Intelligence (WASI; Psychological Corporation, 1999);
  5. comorbid neurologic diseases such as seizure disorder;
  6. Drug or alcohol abuse or dependence disorders in the 4 months prior to study recruitment, although a lifetime history of substance or alcohol disorders can be present if the child has been abstinent for at least 6 months (see further discussion below);
  7. evidence of an unstable medical or psychiatric disorder that requires immediate hospitalization or other emergency medical treatment;
  8. a positive pregnancy test; participants will be encouraged but not mandated to discuss a positive pregnancy test with their guardians and we will follow local laws.
  9. any contraindication for MRI, including metal in the body related to an injury or surgery (e.g., surgical clips, metal fragments in the eyes), piercings that cannot be removed, braces, or permanent retainers.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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