Last updated on July 2016

Adolescents with Depression and/or Anxiety and a Parent or Sibling with Bipolar Disorder

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Participants will receive compensation for their transportation and/or time for the study visits. All study visits, tests, procedures and medication will be provided at no cost to participants. Participants will have MRI scans.

A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder. Subjects will be evaluated using semi-structured diagnostic interviews and symptom ratings, participate in a MRI scan and then randomized to treatment. Following randomization, high-risk youth will have visits every week for the first 4 weeks of treatment then biweekly up to 16 weeks during which time tolerability and ratings will be performed. MRI scan will be repeated at week 4.

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