Understanding how Ketamine brings about rapid improvement in OCD symptoms

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Updated on 23 November 2020


Understanding how Ketamine brings about rapid improvement in OCD symptoms


Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study builds on our discovery that a potent NMDA receptor antagonist, ketamine, has rapid (hours) and robust therapeutic effects in OCD and will help us understand how ketamine works to relieve repetitive thoughts and behaviors.

Purpose: To understand how new drug brings about rapid improvement in OCD symptoms.

This clinical study is funded by the by the National Institute of Mental Health (NIMH).

The Stanford Translational OCD Research Program is looking for adults 18-55 years old with OCD to take part in a study providing these possible benefits:
Free diagnostic evaluation
Free test of your memory and attention
Compensation up to $400 after study completion
Your choice of free OCD psychotherapy or pharmacology after study completion

ClinicalTrials.gov Identifier:

Rodriguez Lab Website: http://rodriguezlab.stanford.edu

Condition Obsessive-Compulsive Disorder
Clinical Study IdentifierTX144376
Last Modified on23 November 2020


Yes No Not Sure

Inclusion Criteria

You can participate if
You are 18-55 years old
You have a primary diagnosis of OCD
You have sufficient severity of OCD symptoms
You have the ability to tolerate a treatment-free period
You have the capacity to provide informed consent
You cannot participate if
You have a psychiatric or medical conditions that make participation unsafe
You are pregnant of nursing female
You have major medical or neurological problem
You have metallic device or dental braces
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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