Last updated on November 2015

Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation (OPTIMAL)


Brief description of study

Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation (OPTIMAL)

Detailed Study Description

The goal of the OPTIMAL study is to gradually reduce anti-rejection medication(s) in liver transplant recipients over a period of time until the medication(s) are stopped. This is called immunosuppression withdrawal.

As part of the OPTIMAL study, investigators will also do blood and liver biopsy tests to see whether they can identify common markers of immune systems that are able to tolerate transplanted livers without immunosuppressive medications. Identification of these markers and tests will help transplant doctors predict whether it is safe to decrease or stop anti-rejection medication(s) for future liver transplant recipients.

In general, study visits will consist of a brief physical exam, and some visits will also include questionnaires as well as blood, urine, stool (fecal), and liver biopsy collections.

In total, participation may last between 3.5 and 6 years.

For more information, visit www.optimalstudy.org

Clinical Study Identifier: TX141786

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Northwestern Memorial University

676 N. Saint Clair, Arkes 19th Fl. Chicago, IL USA
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UPMC Montefiore, 7 South 

3459 Fifth Avenue Pittsburgh, PA USA
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Columbia Medical Center

622 W 168th Street, PH 11 Room 460 New York, NY USA
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Baylor Research Institute

3410 Worth Street, Suite 950 Dallas, TX USA
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