Last updated on March 2015

Rituximab plus Belimumab for Lupus Nephritis (CALIBRATE Study)


Brief description of study

Rituximab plus Belimumab for Lupus Nephritis (CALIBRATE Study)

Detailed Study Description

Lupus nephritis is a severe form of systemic lupus erythematosus (SLE) with active disease in the kidneys. SLE is a complex disease in which the body's own immune system attacks some of the body parts: the skin, the joints, the kidneys, the nervous system, the heart, the lungs and the blood. Treatment for SLE usually involves drugs that are designed to block the immune system attacks. When SLE affects the kidneys (nephritis), stronger immune suppressing treatment is usually needed.

In this experimental study, researchers will try to find out if treatment of lupus nephritis with a combination of rituximab and cyclophosphamide (CTX), or a combination of rituximab and CTX followed by treatment with belimumab is safe and if this drug combination can block the immune system attacks.

For more information, visit www.calibratestudy.org

Clinical Study Identifier: TX140498

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University of Colorado, Denver

1775 Aurora Court, Room M20-2200<br /> Box B115 Aurora, CO USA
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Emory University

49 Jesse Hill Jr. Drive, SE Atlanta, GA USA
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University of California, Los Angeles 

1000 Veteran Ave, Room 32-59 Los Angeles, CA USA
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Colorado Kidney Care

1601 E. 19th Ave, Suite 4300 Denver, CO USA
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Columbia University

630 W. 168th Street, BB 10-1041 New York, NY USA
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University of Texas, Southwestern

5323 Harry Hines Blvd, G4.202 Dallas, TX USA
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Feinstein Institute

350 Community Drive Manhasset, NY USA
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Hospital for Special Surgery

535 East 70th Street New York, NY USA
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University of California, San Francisco

533 Parnassus U-380, UCSF Box 0792 San Francisco, CA USA
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Ohio State University

1581 Dodd Drive, Room 494 Columbus, OH USA
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New York University - Langone Medical Center

333 E. 38th Street, Room 4305 New York, NY USA
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