Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC

  • STATUS
    Recruiting
  • sponsor
    NRG
Updated on 23 November 2020
chemoradiotherapy
non-small cell carcinoma

Summary

Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC

Description

The purpose of this study is to compare any good and bad effects of using the anti-diabetic drug, metformin along with the standard of care radiation therapy and chemotherapy to using the standard of care radiation therapy and chemotherapy alone. The addition of metformin to the usual radiation and chemotherapy could shrink your cancer more than the usual radiation and chemotherapy alone and help prevent it from returning, but it could also cause side effects. This study will allow the researchers to know whether adding metformin to radiation and chemotherapy is better, the same, or worse than radiation and chemotherapy alone. To be better, adding metformin should increase by 10 patients in 100 the ability of radiation and chemotherapy to prevent lung cancer from returning in 1 year compared to the standard of care. Metformin is already FDA-approved for use in diabetes, and studies have shown that it is safe for use in non-diabetic patients.

Details
Condition Non-Small Cell Lung Cancer
Clinical Study IdentifierTX140435
SponsorNRG
Last Modified on23 November 2020

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