Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

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Updated on 23 November 2020


Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)


RESTARRT is a clinical research study that is testing whether a combination of several medications can reset the immune system and help it accept a new kidney without the need for life-long immunosuppression.

The medications used in RESTARRT are anti-thymocyte globulin (ATG), rituximab, mycophenolate mofetil (MMF), tacrolimus and sirolimus. Participants in the RESTARRT study will receive these medications before, during, and after transplant. Standard immunosuppression drugs will initially be prescribed. Eligible participants will be asked to undergo a gradual reduction of their immunosuppressive medication with the goal of stopping these drugs permanently..

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Clinical Study IdentifierTX140071
Last Modified on23 November 2020


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Inclusion Criteria

Selected eligibility criteria include
Age 18-65 years
Plan to receive a kidney transplant and
It is your first transplant
Your kidney is from a living donor who is your first degree relative
You are receiving only a kidney transplant (with no other organs)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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