Comparative analysis of small and large plaque psoriasis
Psoriasis is a chronic, debilitating skin disorder with an estimated prevalence of 2%. Psoriatic skin lesions start with initial pinhead-sized macules and then coalesce into plaques of varying sizes. Despite the great strides in the studies for psoriasis, it is still unclear why psoriatic skin lesions start with small macules and then spread peripherally.
To study peripheral spreading of psoriasis, we plan to study small plaque psoriasis in comparison to large plaque psoriasis in the Korean population. Large plaque psoriasis is the most common form of psoriasis, seen in approximately 90% of all psoriasis participants. Large psoriatic plaques are >5 cm in size and localize to the extensor aspects of the elbows, knees, scalp, and genital area. On the other hand, small plaque psoriasis is the common or typical form of psoriasis that occurs particularly in Korea and other Asian countries. Korean small plaque psoriasis, even when chronic, remains
We hypothesize that the expression of immune-related genes are different between small and large plaque psoriasis. The study of a genetically homogeneous cohort, characterized by the relatively high prevalence of small plaque psoriasis in the Korean population, may filter out spurious signals while allowing for significant associations to emerge from a relatively low number of participants.
Korean participants with small or large plaque psoriasis will be selected from two geographically separated locations: New York, NY, USA and Seoul, South Korea.
To compare treatment response between small and large plaque psoriasis, participants will be offered treatment at the Rockefeller University Hospital Outpatient Research Center with an appropriate dose of narrow band ultra-violet light B radiation (NB-UVB) therapy three times a week for up to 16 weeks. Punch biopsies will be taken at the start and end of the study, and an optional shave biopsy may be collected at the start of the study. Peripheral blood will be collected at the start and end of the study.
By comparing small and large plaque psoriasis, we expect this study could lead to new understandings of the mechanisms involved in spreading of psoriatic plaques and provide new insights into psoriasis development.
Must be Korean
|Clinical Study Identifier||TX137551|
|Last Modified on||23 November 2020|
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