Last updated on May 2019

Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face


Brief description of study

Lentigo malignant (LM) is an intraepidermal melanocytic proliferation occurring on photoexposed skin. In our project, this term applies both to Dubreuilh's melanosis and to Dubreuilh's intraepidermal melanoma. It consequently excludes invasive melanoma. Although surgery is the treatment of choice, it remains without consensus on the margins (5 mm or 10 mm) excision for a localized tumor on the face.

Several studies have shown that imiquimod, activating local immunity by interferon production, induced LM or MLM regression and could also decrease the frequency of relapses.

The principal aim of our project is to study the effect of imiquimod versus placebo in pre-operative neoadjuvant treatment aimed at reducing both surgical margins, as from the first surgical procedure, and the frequency of short and medium term recurrence of LM. Furthermore, the improvement in patient quality of life could also be significant.

Detailed Study Description

The primary endpoint of the study is to demonstrate that neoadjuvant treatment of LM by imiquimod prior to surgery can reduce the frequency of intralesional excisions as from the first surgical procedure, with a healthy tissue margin of 5mm. Furthermore, the improvement in patient quality of life could also be significant.

The number of patients to be included in the study is 268.

For each patient, the study will involve several stages (S), as follows:

S0 (Selection): information and obtaining of the patient's informed consent. Performance of biopsy for histological confirmation of LM

S1 (S0 + ~ 2 weeks): patient inclusion following anatomopathological confirmation of LM. Patient randomisation in one or other study arm: imiquimod versus placebo and initiation of topical treatment.

S2 (S1 + 4 weeks): Discontinuation of imiquimod/placebo application. Scheduling of the surgical procedure 4 weeks later.

S3 (S2 + 4 weeks): Surgery.

S4: After the last surgical procedure, simple clinical follow up will be ensured every 6 months for a period of 3 years, in order to study the recurrence rate.

Clinical Study Identifier: NCT01720407

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CHU

Besançon, France
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CHU

Besançon, France
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AP-HP H pital Ambroise Par

Boulogne Billancourt, France
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CHU

Brest, France
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CHRU

Caen, France
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CHU Michallon

Grenoble, France
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Le Mans, France
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CHRU

Lille, France
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CHU

Limoges, France
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CHU

Lyon, France
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AP-HM

Marseille, France
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CHU

Montpellier, France
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CHU

Nice, France
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CHU

Orléans, France
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CHU Mil trie

Poitiers, France
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CHU

Reims, France
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CHU

Saint-Etienne, France
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Chu (Iucto)

Toulouse, France
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CHU

Tours, France
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CHU

Besançon, France
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CHU

Orléans, France
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Recruitment Status: Open


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