Last updated on February 2018

Canadian Rotavirus Surveillance Through the Immunization Monitoring Program Active (IMPACT)

Brief description of study

  • Rotavirus Hospital Admissions Surveillance
    • Retrospective surveillance for 2010 and 2011 for hospital admissions in children aged 0 to 16 years due to rotavirus gastroenteritis will be completed by all centers of the IMPACT (Immunization Monitoring Program, ACTive) pediatric hospital network.
    • Prospective surveillance of rotavirus-related admissions for children aged 0 to 16 years was conducted in 2012-14 inclusive and will be performed for an additional three years, 2015, 2016 and 2017 at all 12 sites. Surveillance methodology will continue using the same case-finding strategy and the same case report form as in past surveillance (Case reporting is done electronically.
    • Emergency Department Burden of Disease Case finding for all-cause diarrheal illness using ICD codes was undertaken prospectively for 2012 to 2014 and will not continue in the years 2015-17 inclusive. Systematic stool sampling was carried out for cases of gastroenteritis in children < 5 years of age presenting to the ED departments at the IMPACT hospitals in 2012 and 2013 and 5 of the 12 center hospitals in 2014. This component will not continue in to the 2015-17 protocol study years. However the admitted cases presenting to the IMPACT center hospitals with positive rotavirus will be reported and stool samples saved for genotyping at a later date.

Detailed Study Description

This study has the ability to provide contemporary Canadian data on the two of the most important outcome measures for effectiveness of rotavirus vaccine: hospital admissions and emergency department visits. The extended time period that already exists prior to vaccine implementation (2005 to 2011) will provide longterm baseline data with which to compare disease burden from 2012 to 2017.

The major advantages to this study are that surveillance occurs at the same hospitals and the same methodology and CRF has been used since 2005. This will ensure reliability and consistency in the surveillance study. The national data set captures patients from age group 0 to 16 years in 12 centers across the country. The retrospective and prospective studies will be in a unique position to capture all children admitted to the 12 pediatric hospitals in Canada. Since reliance on discharge codes alone may underestimate gastroenteritis due to rotavirus, laboratory surveillance coupled with medical record review will ensure the complete capture of the true disease burden. Data on the health status of children will facilitate the evaluation of children who are medically fragile for which rotavirus infections may be more significant.

Clinical Study Identifier: NCT01633190

Contact Investigators or Research Sites near you

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Taj Jadavji, MD

Alberta Children`s Hospital
Calgary, AB Canada
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Wendy Vaudry, MD

Stollery Children`s Hospital
Edmonton, AB Canada
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Manish Sadarangani, MD

BC Children`s Hospital
Vancouver, BC Canada
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Joanne Embree, MD

Winnipeg Children`s Hospital
Winnipeg, MB Canada
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Natalie Bridger, MD

Janeway Children`s Health and Rehabilitation Center
St. John`s, NL Canada
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Karina Top, MD

IWK Health Centre
Halifax, NS Canada
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Nicole Le Saux, MD

Children`s Hospital of Eastern Ontario
Ottawa, ON Canada
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Shaun Morris, MD

The Hospital for Sick Children
Toronto, ON Canada
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Marie-Astrid Lefebvre, MD

Montreal Children`s Hospital
Montreal, QC Canada
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Roseline Thibeault, MD

Centre M re-Enfant de Qu bec -Pavillon CHUL
Ste Foy, QC Canada
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Ben Tan, MD

Royal University Hospital
Saskatoon, SK Canada
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Marc Lebel, MD

CHU Sainte-Justine Hospital
Montréal, QC Canada
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Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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