Effects of Brain Beta-Amyloid on Postoperative Cognition

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    University of California, San Francisco
Updated on 29 June 2022
dementia
cognitive decline
18f-av-45

Summary

Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age.

This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement.

The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline.

Details
Condition Postoperative Cognitive Dysfunction
Treatment No intervention, Florbetapir F 18 (18F-AV-45)
Clinical Study IdentifierNCT01606488
SponsorUniversity of California, San Francisco
Last Modified on29 June 2022

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