Efficacy and Safety Study of Trastuzumab Paclitaxel and Carboplatin on HER2+ Preoperative Breast Cancer

  • STATUS
    Recruiting
  • participants needed
    60
  • sponsor
    Fudan University
Updated on 8 November 2020
paclitaxel
carboplatin
advanced breast cancer
HER2
trastuzumab
erbb2
cish
invasive breast cancer
inflammatory breast cancer
core needle biopsy
chromogenic in situ hybridization

Summary

To compare the efficacy in terms of the pathological complete response rate (pCR) to preoperative administration of qw or q3w Paclitaxel, Carboplatin and Trastuzumab (PCH)

Description

Currently Herceptin has moved to Neoadjuvant treatment combined with chemotherapy. Paclitaxel and Carboplatin are two of the best partners with high pCR. The significant efficacy and good safety profile of Herceptin® combination with taxane as adjuvant treatment on EBC are accepted; 1 year of Herceptin as adjuvant treatment is one standard therapy. This study is one small Phase II trial to explore the efficacy and safety of QW and Q3W of PCH as Neoadjuvant treatment, we only plan 60 pts and the trend of the two curves is anticipated

Details
Condition Breast Cancer
Treatment Trastuzumab QW, Trastuzumab Q3W
Clinical Study IdentifierNCT01170143
SponsorFudan University
Last Modified on8 November 2020

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