Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy

  • STATUS
    Recruiting
  • participants needed
    12
  • sponsor
    Columbia University
Updated on 8 August 2022
diabetes
insulin
pituitary
serum pregnancy test
fasting
somatomedin c
thyroxine
replacement therapy
testosterone
blood sugar
GH deficiency
glucagon
pituitary hormones
insulin tolerance
insulin tolerance test

Summary

In order to examine the effect of GH on adipose tissue inflammation, this study will examine adipose tissue and serum inflammation in patients with GH deficiency before and after GH therapy. The investigators will also obtain serum samples before and after treatment for adipokines, inflammatory markers and examine macrophages in circulation with regard to their inflammatory state. The investigators will also obtain adipose tissue biopsies from healthy subjects matched to the growth hormone deficiency (GHD) subjects. Adipose tissue specimens will be analyzed for adipose tissue morphology, adipocyte size, adipokine gene expression, and adipose tissue macrophage number.

Description

The growth hormone (GH) axis has important influences on adipose tissue. GH may have a novel effect to reduce macrophage yet increase adipocyte inflammation in adipose tissue along with reducing adipose tissue mass. Disordered adipose tissue metabolism may dysregulate adipokine secretion, which could contribute to metabolic abnormalities in GH deficiency. Adipokines, peptides expressed and secreted by adipose tissue, exert important local adipose tissue and systemic metabolic effects. This study will combine direct assessment of adipose tissue with assessment of body composition. Adult GHD can be associated with central adiposity, insulin resistance, dyslipidemia and increased cardiovascular (CV) risk.

Details
Condition Growth Hormone Deficiency
Treatment Growth hormone
Clinical Study IdentifierNCT03225755
SponsorColumbia University
Last Modified on8 August 2022

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