Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

  • STATUS
    Recruiting
  • End date
    Dec 27, 2023
  • participants needed
    388
  • sponsor
    Merck Sharp & Dohme Corp.
Updated on 24 September 2021

Summary

This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of quavonlimab when used in combination with pembrolizumab in participants with advanced solid tumors.

Description

After screening, participants will be assigned to the Dose Escalation, Dose Confirmation, Efficacy Expansion, or Coformulation Phase. The Dose Escalation Phase will evaluate available PK and safety data including dose limiting toxicities (DLTs). The Dose Confirmation Phase will gather additional safety, tolerability, PK, and preliminary efficacy data of quavonlimab in combination with pembrolizumab, and will include first-line advanced/metastatic non-small cell lung cancer (NSCLC) and second line (and beyond) advanced/metastatic small cell lung cancer (SCLC). The purpose of the Efficacy Expansion Phase is to gather preliminary anti-tumor efficacy data for quavonlimab in combination with pembrolizumab as well as for quavonlimab monotherapy in the specific target population of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) refractory melanoma. The Coformulation Phase will evaluate the safety and PK of a coformulated product of pembrolizumab/quavonlimab (MK-1308A) in comparison to that of the single, co-administered products given at the same dose and schedule, and include participants with advanced solid tumors, PD-1/L1 refractory advanced melanoma, and participants from mainland China.

Details
Condition Advanced Solid Tumors
Treatment cisplatin, carboplatin, Paclitaxel, Pembrolizumab, Pemetrexed, Nab-paclitaxel, MK-1308, MK-1308A, Quavonlimab, Pembrolizumab/Quavonlimab
Clinical Study IdentifierNCT03179436
SponsorMerck Sharp & Dohme Corp.
Last Modified on24 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

For Dose Escalation Phase
Have any histologically- or cytologically-confirmed advanced/metastatic solid tumor (except NSCLC for Cohorts 2 and 3) by pathology report and have received, been intolerant to, been ineligible for, or refused all treatment known to confer clinical benefit
For Dose Confirmation Phase NSCLC Arms (A, B, C, and E)
Have newly diagnosed histologically or cytologically-confirmed stage IIIB/stage IV NSCLC. Epidermal growth factor receptor (EGFR)-and anaplastic lymphoma kinase (ALK) translocation-directed therapy is not indicated as primary therapy. Participant must not have received prior systemic treatment for advanced NSCLC or must have received previous neoadjuvant and adjuvant chemotherapies 6 months before dosing of study drug if prior systemic treatment was given for early stage disease
For Dose Confirmation Phase SCLC Arm (Arm D)
Have histologically- or cytologically-confirmed metastatic (Stage III/IV) SCLC with progressive disease after 1 platinum-based chemotherapy regimen. Participants with platinum-sensitive disease are eligible
Have measurable disease by RECIST 1.1 as assessed by the local site investigator/radiology
Have Eastern Cooperative Oncology Group (ECOG) Performance Scale status of 0 or 1
A female participant is eligible to participate if she is not pregnant or breastfeeding and at least 1 of the following conditions applies
Male participants with a female partner(s) of child-bearing potential must be willing to use an adequate method of contraception for the course of the study through 120 days after the last dose of study medication and refrain from donating sperm during this period
Is not a woman of child bearing potential (WOCBP) OR
Must submit an evaluable baseline tumor sample for analysis (either a recent or archival tumor sample)
Is a WOCBP and using a contraceptive method that is highly effective during the intervention period and for at least 120 days after the last dose of pembrolizumab or pembrolizumab/quavonlimab, whichever comes last
Female participants of childbearing potential must have negative urine or serum pregnancy test within 24 hours for urine and within 72 hours for serum prior to receiving the first dose of study treatment
Have histologically/cytologically-confirmed unresectable Stage III or Stage IV melanoma per American Joint Committee on Cancer (AJCC) staging system version 8, not amenable to local therapy
For Efficacy Expansion Phase Arms F and G and Coformulation Phase Arm J
Participants who receive anti-PD-1 therapy as adjuvant treatment following complete resection of Stage III or IV melanoma and have disease recurrence (unresectable loco-regional disease or distant metastases) while on active treatment or within 6 months of stopping anti-PD-1 are eligible
Have at least 1 measurable lesion by CT or MRI per RECIST 1.1 by BICR. Cutaneous lesions and other superficial lesions are not considered measurable lesions for the purposes of this protocol, but may be considered as non-target lesions
Have submitted pre-trial imaging and provided a baseline tumor sample
Participants with unresectable Stage III or IV disease must have progressed on treatment with an anti-PD-1/L1 monoclonal antibody (mAb) administered either as monotherapy, or in combination with other checkpoint inhibitors or other therapies (combinations with anti-cytotoxic T-lymphocyte associated protein 4 [CTLA-4] agents will not be allowed)
For Dose Coformulation Phase Arm I
Have any histologically- or cytologically-confirmed advanced/metastatic solid tumor by pathology report and have received, been intolerant to, been ineligible for or refused all treatment known to confer clinical benefit
Proto-oncogene B-raf (BRAF) V600 mutation-positive melanoma participants should have received targeted therapy for advanced or metastatic disease (eg, BRAF/MEK inhibitor, alone or in combination) prior to enrolling on this study; however, they are not required to progress on this treatment prior to enrollment
Meet all requirements for Dose Escalation Phase and Dose Confirmation Phase
BRAF V600E mutation-positive melanoma participants who have NOT received a BRAF inhibitor (either as adjuvant therapy or in the metastatic disease setting) with lactate dehydrogenase (LDH) < local upper limit of normal (ULN), no clinically significant tumor-related symptoms, and absence of rapidly progressing metastatic melanoma. Approximately 10 participants each from Arms F, G, and J will have 2 mandatory biopsies
For the Coformulation Phase - Arm K (China only)
Have any histologically- or cytologically-confirmed advanced/metastatic solid tumor by pathology report and have received, been intolerant to, been ineligible for, or refused all treatment known to confer clinical benefit
Be a Chinese participant residing in China

Exclusion Criteria

For all phases of the study: Has received previous treatment with another agent targeting cytotoxic T lymphocyte leukocyte antigen (CTLA)-4
Has received previous treatment with another agent targeting programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), or anti PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor
Has had chemotherapy, definitive radiation, or biological cancer therapy within 4 weeks (2 weeks for palliative radiation) prior to the first dose of study therapy, or has not recovered to Common Toxicity Criteria for Adverse Events (CTCAE) Grade 1 or better from any AEs that were due to cancer therapeutics administered more than 4 weeks earlier
Has received lung radiation therapy of >30 Gray (Gy) within 6 months before the first dose of study treatment
Has a history of a second malignancy, unless potentially curative treatment has been completed with no evidence of malignancy for 3 years
For Dose Confirmation Phase
Has known untreated central nervous system (CNS) metastases. Has known carcinomatous meningitis
Has received any prior immunotherapy and was discontinued from that treatment due to a Grade 3 or higher immune-related adverse events (irAE)
Has had a severe hypersensitivity reaction to treatment with any monoclonal antibody or components of the study drug
Has any active infection requiring therapy
For Dose Escalation Cohorts (1-3) and Dose Confirmation Arms (A-E)
Has an active autoimmune disease that has required systemic treatment in the past 2 years
Has clinically significant cardiac disease
Has known history of human immunodeficiency virus (HIV) and/or known active Hepatitis B or C infections, and/or known to be positive for hepatitis B surface antigen (HBsAg)/ hepatitis B virus (HBV) DNA
Has known psychiatric or substance abuse disorders that would interfere with the participant's ability to cooperate with the requirements of the trial
Has not fully recovered from any effects of major surgery without significant detectable infection
Has known active CNS metastases and/or carcinomatous meningitis
Has received a live or live attenuated vaccine within 28 days of planned treatment start
Is currently participating and receiving study therapy in a study of an investigational agent or has participated and received study therapy in a study of an investigational agent or has used an investigational device within 28 days of administration of quavonlimab
Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study, starting with screening and for up to 120 days following cessation of pembrolizumab or pembrolizumab/quavonlimab
Has had an allogenic tissue/solid organ transplant
For Arm F and G (Efficacy Expansion Phase) and Arm J and K (Coformulation
Phase) ONLY
Has a history of interstitial lung disease, history of noninfectious pneumonitis that required steroids (or has current pneumonitis), or history of inflammatory bowel disease
Has not had resolution of anti-PD-1 antibody-related AEs, including immune-mediated AEs back to Grade 1 or baseline (not applicable to Arm K)
Has not discontinued steroid treatment for an irAE for at least 2 weeks prior to the first dose of study drug (not applicable to Arm K)
Has ocular melanoma (not applicable to Arm K)
Has mucosal melanoma (not applicable to Arm K)
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