Last updated on March 2019

Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma

Brief description of study

This study will evaluate the preliminary efficacy, safety, and pharmacokinetics of cobimetinib and atezolizumab in participants with advanced BRAF V600-wild type (WT), metastatic, or unresectable locally advanced melanoma who have progressed on prior antiPD-1 therapy. In addition, this study will evaluate the efficacy, safety, and pharmacokinetics of atezolizumab monotherapy in participants with BRAFV600-WT metastatic or unresectable locally advanced melanoma, who have not been previously treated.

Clinical Study Identifier: NCT03178851

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HonorHealth Research Institute - Pima Center

Scottsdale, AZ United States

Angeles Clinic & Rsch Inst

Los Angeles, CA United States

Karmanos Cancer Institute

Detroit, MI United States

Washington University School of Medicine

Saint Louis, MO United States

Sarah Cannon Research Institute

Nashville, TN United States

Baylor University Medical Center

Dallas, TX United States

Blacktown Hospital

Blacktown, Australia

Melanoma Institute Australia

North Sydney, Australia

Peter Maccallum Cancer Centre

Melbourne, Australia

Cape Town Oncology Trials

Cape Town, South Africa

GVI Constantiaberg

Cape Town, South Africa

Johese Clinical Research

Centurion, South Africa


Port Elizabeth, South Africa

Hospital Clinic I Provincial

Barcelona, Spain

Hospital S o Lucas da PUCRS

Porto Alegre, Brazil

Mid North Coast Cancer Institute

Port Macquarie, Australia

Flinders Medical Centre

Bedford Park, Australia

University Clinic Ctr Sarajevo

Sarajevo, Bosnia and Herzegovina

Seoul National University Hospital

Seoul, Korea, Republic of

Severance Hospital

Seoul, Korea, Republic of

Asan Medical Center

Seoul, Korea, Republic of

Samsung Medical Center

Seoul, Korea, Republic of

Alfred Hospital

Melbourne, Australia

University Clinical Centre of the Republic of Srpska

Banja Luka, Bosnia and Herzegovina

Hospital S o Vicente de Paulo

Passo Fundo, Brazil


George, South Africa

Recruitment Status: Closed

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