Last updated on June 2019

An Efficacy Study Comparing Oral Ixazomib/Dexamethasone and Oral Pomalidomide/Dexamethasone in Relapsed and/or Refractory Multiple Myeloma

Brief description of study

The purpose of this study is to compare the effect of ixazomib + dexamethasone (ixa + dex) versus pomalidomide + dexamethasone (pom + dex) on progression-free survival (PFS) in participants with relapsed and/or refractory multiple myeloma (RRMM) who have received at least 2 prior lines of therapy, including lenalidomide and a proteasome inhibitor, and are refractory to lenalidomide but not refractory to proteasome inhibitors.

Detailed Study Description

The drug being tested in this study is called Ixazomib. Ixazomib is being tested to treat people who have RRMM. This study will compare the efficacy and safety in participants who take ixazomib and dexamethasone to pomalidomide and dexamethasone. It is an open-label, phase 2 study that, on the basis of a prespecified go/no-go decision rule, will progress to a phase 3 registrational study.

The study will enroll approximately 300 patients. Participants will receive:

  • Ixazomib 4 mg + dexamethasone 20 mg (or 10 mg if participant is aged >=75 years) OR
  • pomalidomide 4 mg + dexamethasone 40 mg (or 20 mg if participant is aged >=75 years)

All participants will be asked to take either ixazomib plus dexamethasone (in cases where only 4 mg tablets for dexamethasone are available, the following dexamethasone schedule is recommended for participants aged >=75 years: 12 mg dexamethasone will be given on Days 1, 8, 15, and 22 of every 28-day cycle; and 8 mg dexamethasone will be given on Days 2, 9, 16, and 23 of every 28-day cycle) or pomalidomide 4 mg + dexamethasone 40 mg at recommended doses.

This multi-center trial will be conducted worldwide. The overall time to participate in this study is approximately 63 months if the phase 3 portion of the study is completed. Alternatively, if the no-go criteria are met during the phase 2 portion, the study will be completed approximately 22 to 29 months after the first participant enters the study.

Participants will make multiple visits to the clinic, and will be contacted for PFS follow-up, in case of study drug discontinuation for up to 7 years from first dose administration. After disease progression, participants will be followed-up for OS every 12 weeks until death or up to 10 years.

Clinical Study Identifier: NCT03170882

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Highlands Oncology Group

Fayetteville, AR United States
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St Joseph Heritage Healthcare

Santa Rosa, CA United States
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Lynn Cancer Institute

Boca Raton, FL United States
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University of Florida

Gainesville, FL United States
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Mid Florida Cancer Center

Sanford, FL United States
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University of Maryland

Baltimore, MD United States
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Saint Agnes Hospital

Baltimore, MD United States
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Henry Ford Health System

Detroit, MI United States
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Michigan State University

Lansing, MI United States
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Mayo Clinic

Rochester, MN United States
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San Juan Oncology Associates

Farmington, NM United States
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The Queen Elizabeth Hospital

Woodville South, Australia
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Box Hill Hospital

Box Hill, Australia
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Fakultni nemocnice Plzen

Plzen Lochotin, Czechia
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CHRU Nancy

Vandoeuvre Les Nancy, France
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Centre Hospitalier Fleyriat

Bourg-en- Bresse Cedex, France
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CHRU Rennes

Rennes Cedex 9, France
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City Clinical Hospital # 40

Moscow, Russian Federation
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Addenbrooke s Hospital

Cambridge, United Kingdom
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Royal Bournemouth Hospital

Bournemouth, United Kingdom
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Kent and Canterbury Hospital

Canterbury, United Kingdom
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GenesisCare Oxford

Oxford, United Kingdom
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Royal Stoke University Hospital

Stoke-on-Trent, United Kingdom
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Leicester Royal Infirmary

Leicester, United Kingdom
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Singleton Hospital

Swansea, United Kingdom
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New Cross Hospital

Wolverhampton, United Kingdom
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Recruitment Status: Open

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