Last updated on October 2018

A Study to Evaluate Efficacy Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)


Brief description of study

The purpose of this study is to assess the effect of CK-2127107 versus placebo on respiratory function and other measures of skeletal muscle function in patients with ALS.

Detailed Study Description

Enrolled participants will be dosed with CK-2127107 150, 300, 450 mg or placebo twice daily (300, 600, 900 mg/day or placebo) for a period of 12 weeks.

Clinical Study Identifier: NCT03160898

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Jacquelyn Nicolari

St. Joseph's Hospital and Medical Center - Barrow Neurological Clinics
Phoenix, AZ United States
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Michael Nguyen

Stanford Hospital and Clinics
Stanford, CA United States
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Cindy Rohde, RN

Hennepin County Medical Center
Minneapolis, MN United States
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Shara Holzberg

Hospital For Special Surgery
New York, NY United States
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Mozhdeh Marandi

Wake Forest School of Medicine
Winston-Salem, NC United States
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Ifeanyi Okoh

The Ohio State University Wexner Medical Center
Columbus, OH United States
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Arlena Cummings

Providence Brain and Spine Institute ALS Center
Portland, OR United States
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Todd Morgan

Texas Neurology
Dallas, TX United States
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Pamela Kittrell, MSN RN

UTHSCSA Medical Arts and Research Center
San Antonio, TX United States
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West Virginia University, Dept. of Neurology
Morgantown, WV United States
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Montreal Neurological Institute and Hospital
Montreal, QC Canada
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Ivonne Turner

University of California Irvine
Orange, CA United States
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Marguerite Engel

Forbes Norris MDA/ALS Research Center
San Francisco, CA United States
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Nicola Haakonsen

University of Colorado Hospital Anschutz Outpatient Pavilion
Aurora, CO United States
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Hospital for Special Care
New Britain, CT United States
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Jacquelyn Hill

Duchossois Center for Advanced Medicine
Chicago, IL United States
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IU Health Neuroscience Center of Excellence
Indianapolis, IN United States
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Ayla McCalley

University of Kansas Medical Center
Kansas City, KS United States
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Kristin M. Riley, PhD

Johns Hopkins University - Outpatient Center
Baltimore, MD United States
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University of Massachusetts Memorial Medical Center/University of Massachusetts Medical School
Worcester, MA United States
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Jayna Duell

Michigan Medicine
Ann Arbor, MI United States
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Ashkhen Movsisyan

Henry Ford Health System
Detroit, MI United States
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Saint Louis University, Department of Neurology
Saint Louis, MO United States
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Washington University School of Medicine
Saint Louis, MO United States
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Kelli Ferguson

Neurology Associates, P.C.
Lincoln, NE United States
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Neurological Institute, Columbia University Medical Center
New York, NY United States
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SUNY Upstate Medical University
Syracuse, NY United States
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Neurosciences Institute, Neurology - Charlotte
Charlotte, NC United States
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Karen Grace

Duke Neurological Disorders Clinic
Durham, NC United States
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Cleveland Clinic
Cleveland, OH United States
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Penn State Milton S. Hershey Medical Center
Hershey, PA United States
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Diana Davis

Vanderbilt University Medical Center - Clinical Research Center
Nashville, TN United States
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Mary Wagoner

University of Virginia Health System
Charlottesville, VA United States
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Laura Sissons-Ross

University of Washington Medical Center
Seattle, WA United States
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Lynn Wheeler

Froedtert Memorial Lutheran Hospital
Milwaukee, WI United States
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Jose Antonio Martinez

University of Calgary, Heritage Medical Research Center
Calgary, AB Canada
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Daniela Trapsa

McMaster University Medical Centre
Hamilton, ON Canada
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Sunnybrook Health Science Centre
Toronto, ON Canada
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CHU de Quebec-Universite Laval, Hopital de l'Enfant Jesus
Quebec, QC Canada
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Koral Wheeler

Cedars-Sinai Medical Center
Los Angeles, CA United States
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Pamela Desaro

Mayo Clinic
Jacksonville, FL United States
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Meraida Polak

Emory Clinic
Atlanta, GA United States
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Mayo Clinic
Rochester, MN United States
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Luis F Lay, Jr.

Houston Methodist Hospital
Houston, TX United States
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University of Vermont Medical Center
Burlington, VT United States
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Shelley Wrona

Edmonton Kaye Clinic
Edmonton, AB Canada
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Tamika Walthour

VCU Health - Ambulatory Care Center (ACC)
Richmond, VA United States
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George Washington University Medical Faculty Associates
Washington, WA United States
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Carol & Frank Morsani Center for Advanced Healthcare - University of South Florida
Tampa, FL United States
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University of Florida
Gainesville, FL United States
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Jeri Sieren

University of Iowa Hospitals and Clinics
Iowa City, IA United States
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London Health Sciences Centre University Hospital
London, ON Canada
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Kathleen Hatala

Temple University School of Medicine
Philadelphia, PA United States
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Royal Brisbane and Women's Hospital
Herston, Australia
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Flinders Medical Centre
Bedford Park, Australia
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The Perron Institute for Neurological and Translation Science
Nedlands, Australia
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Eleanor Ramsey

Brain and Mind Centre, The University of Sydney
Camperdown, Australia
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Janet DeGirolamo, RN

Saskatoon City Hospital
Saskatoon, SK Canada
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Hospital San Rafael Servicio de Neurologia
Madrid, Spain
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Department of Neurology, Westmead Hospital
Westmead, Australia
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Tommy Bunte

University Medical Center Utrecht
Utrecht, Netherlands
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Oregon Health & Science University
Portland, OR United States
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Stefanie Houle

Centre de recherche du Centre Hospitalier de l'Universite de Montreal
Montréal, QC Canada
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Beaumont Hospital
Dublin, Ireland
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Recruitment Status: Open


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