Last updated on April 2019

Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer

Brief description of study

The purpose of this study is to evaluate the safety and efficacy of the study drug abemaciclib in participants with high risk, node positive, early stage, hormone receptor positive (HR+), human epidermal receptor 2 negative (HER2-), breast cancer.

Clinical Study Identifier: NCT03155997

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University of Alabama Birmingham

Birmingham, AL United States

Banner MD Anderson Cancer Center

Gilbert, AZ United States

University of Arizona Cancer Center

Phoenix, AZ United States

Highlands Oncology Group

Fayetteville, AR United States

St. Bernards Medical Center

Jonesboro, AR United States

Beverly Hills Cancer Center

Beverly Hills, CA United States

Cancer Center of Santa Barbara with Sansum Clinic

Santa Barbara, CA United States

Florida Cancer Specialists

Fort Myers, FL United States

Ocala Oncology, P.A.

Ocala, FL United States

Millennium Oncology

Pembroke Pines, FL United States

Florida Cancer Specialists

Saint Petersburg, FL United States

Tallahassee Memorial Cancer Center

Tallahassee, FL United States

Northeast Georgia Cancer Care, LLC

Athens, GA United States

Central Georgia Cancer Care, PC

Macon, GA United States

Northwest Georgia Oncology Centers

Marietta, GA United States

Illinois Cancer Specialists-Niles

Niles, IL United States

Quincy Medical Group

Quincy, IL United States

Franciscan St. Francis Health

Indianapolis, IN United States

Community Howard Oncology Center

Kokomo, IN United States

Research Medical Center

Kansas City, KS United States

Univ of Louisville School of Medicine

Louisville, KY United States

Reliant Medical Group, Inc.

Worcester, MA United States

Jackson Oncology Associates PLLC

Jackson, MS United States

Oncology Hematology West

Omaha, NE United States

Dartmouth Hitchcock Medical Center

Lebanon, NH United States

Valley Health System

Paramus, NJ United States

New York Oncology Hematology Associate

Albany, NY United States

Weill Cornell Medical College

New York, NY United States

SUNY At Stony Brook

Stony Brook, NY United States

White Plains Hospital

White Plains, NY United States

Oncology Hematology Care Inc

Cincinnati, OH United States

Hematology Oncology Associates, PC

Medford, OR United States

OHSU Knight Cancer Institute

Portland, OR United States

St. Luke's Hospital & Health Network

Bethlehem, PA United States

University of Tennessee Medical Center

Knoxville, TN United States

Tennessee Oncology PLLC

Nashville, TN United States

Texas Oncology-Arlington South

Arlington, TX United States

Texas Oncology P.A.

Carrollton, TX United States

Texas Oncology P.A.

Dallas, TX United States

Texas Oncology - Medical City Dallas

Dallas, TX United States

Texas Oncology Denton

Denton, TX United States

Oncology Consultants Cancer Center

Houston, TX United States

Texas Oncology - Paris

Paris, TX United States

Texas Oncology-Plano East

Plano, TX United States

Texas Oncology-Plano West

Plano, TX United States

Texas Oncology - San Antonio Medical Center

San Antonio, TX United States

Texas Oncology-Sherman

Sherman, TX United States

US Oncology

The Woodlands, TX United States

Shenandoah Oncology, P.C.

Winchester, VA United States

Katmai Oncology Group

Anchorage, AK United States

Providence St. Joseph's Medical Center

Burbank, CA United States

Loma Linda University School of Medicine

Loma Linda, CA United States

Cedars Sinai Medical Center

Los Angeles, CA United States

Pacific Cancer Care

Monterey, CA United States

Univ of California San Francisco

San Francisco, CA United States

Kaiser Permanente

Vallejo, CA United States

Cancer Specialists of North Florida -St Augustine

Saint Augustine, FL United States

H Lee Moffitt Cancer Center

Tampa, FL United States

University of Hawaii Cancer Center

Honolulu, HI United States

John H. Stroger Hospital of Cook County

Chicago, IL United States

Lady of the Lake Physicians' Group

Baton Rouge, LA United States

Cancer Alliance of Nebraska

Omaha, NE United States

Nebraska Methodist Cancer Center

Omaha, NE United States

Newark Beth Israel Medical Center

Newark, NJ United States

Community Medical Center

Toms River, NJ United States

Vassar Brothers Medical Center

Poughkeepsie, NY United States

Waverly Hematology Oncology

Cary, NC United States

Margaret R. Pardee Memorial Hospital

Hendersonville, NC United States

Wake Forest University Health Sciences

Winston-Salem, NC United States

Aultman Hospital

Canton, OH United States

Cleveland Clinic Foundation

Cleveland, OH United States

Albert Einstein Healthcare Network

Philadelphia, PA United States

Allegheny General Hospital

Pittsburgh, PA United States

Univ of Pittsburgh Cancer Inst. (UPCI)

Pittsburgh, PA United States

McLeod Regional Medical Center

Florence, SC United States

Bon Secours Saint Francis Cancer Center

Greenville, SC United States

Spartanburg Regional Medical Center

Spartanburg, SC United States

Texas Oncology Fort Worth

Fort Worth, TX United States

Scott & White Memorial Hospital & Clinic

Temple, TX United States

Multicare Health System

Tacoma, WA United States

Marshfield Clinic

Marshfield, WI United States

Edward Cancer Center

Naperville, IL United States

Meritus John Marsh Cancer Center

Hagerstown, MD United States

Dana Farber Cancer Institute

Boston, MA United States

University Hospitals Case Medical Center

Cleveland, OH United States

PinnacleHealth Cancer Institute

Harrisburg, PA United States

Baptist Cancer Center

Memphis, TN United States

Texas Oncology Cancer Center

Austin, TX United States

Swedish Medical Center

Seattle, WA United States

Yale University School of Medicine

New Haven, CT United States

UT/Erlanger Oncology & Hematology

Chattanooga, TN United States

Tennessee Oncology PLLC

Chattanooga, TN United States

New England Cancer Specialists - Scarborough

Scarborough, ME United States

Texas Oncology - Amarillo

Amarillo, TX United States

Associates In Hematology/Oncology PC

Bethesda, MD United States

Tyler Cancer Center

Tyler, TX United States

Virginia Cancer Specialists

Fairfax, VA United States

Arizona Oncology Associates, P.C.

Tucson, AZ United States

Rocky Mountain Cancer Center

Denver, CO United States

Northside Hospital Cancer Institute

Atlanta, GA United States

Terrebonne General Medical Center

Houma, LA United States

Central Maine Healthcare Corporation

Lewiston, ME United States

Minnesota Oncology/Hematology PA

Minneapolis, MN United States

Comprehensive Cancer Centers of Nevada

Las Vegas, NV United States

The West Clinic

Germantown, TN United States

Cancer Care Centers of South Texas

San Antonio, TX United States

Virginia Oncology Associates

Norfolk, VA United States

Summit Cancer Care

Savannah, GA United States

Mayo Clinic

Rochester, MN United States

Summit Medical Group PA

Florham Park, NJ United States

Mayo Clinic Hospital

Phoenix, AZ United States

Arizona Oncology Associates, P.C.

Tempe, AZ United States

The University of Arizona Cancer Center

Tucson, AZ United States

Yuma Regional Cancer Center

Yuma, AZ United States

City of Hope National Medical Center

Duarte, CA United States

Mayo Clinic-Jacksonville

Jacksonville, FL United States

Palm Beach Cancer Institue

West Palm Beach, FL United States

Cancer Center of Kansas

Wichita, KS United States

Eastern Maine Medical Center

Brewer, ME United States

Renown Medical Group

Reno, NV United States

Montefiore Medical Center

Bronx, NY United States

Broome Oncology LLC

Johnson City, NY United States

Sanford Research/USD

Sioux Falls, SD United States

Brig Center For Cancer Care and Survivorship

Knoxville, TN United States

Sarah Cannon Cancer Center

Nashville, TN United States

Texas Oncology-McKinney

McKinney, TX United States

Texas Oncology- Mesquite

Mesquite, TX United States

Texas Oncology - The Woodlands

Shenandoah, TX United States

Utah Cancer Specialists

Salt Lake City, UT United States


Caba, Argentina

Clinica Adventista de Belgrano

Ciudad de Buenos Aires, Argentina

Centro Medico San Roque

S.M. De Tucuman, Argentina

Instituto Alexander Fleming

Buenos Aires, Argentina

Hospital Aleman

Capital Federal, Argentina

Sanatorio Parque

Salta, Argentina

Chris O'Brien Lifehouse

Camperdown, Australia

Lismore Base Hospital

Lismore, Australia

Liverpool Hospital

Liverpool, Australia

Calvary Mater Newcastle

Newcastle, Australia

Mater Private Hospital

North Sydney, Australia

St Vincent's Hospital

Sydney, Australia

Westmead Hospital

Westmead, Australia

Southern Medical Day Care Centre

Wollongong, Australia

The Townsville Hospital

Douglas, Australia

Mater Adult Hospital Brisbane

South Brisbane, Australia

Gold Coast University Hospital

Southport, Australia

Lyell McEwin Hospital

Elizabeth Vale, Australia

Ashford Cancer Centre Research

Kurralta Park, Australia

Launceston General Hospital

Launceston, Australia

Box Hill Hospital

Box Hill, Australia

Epworth Research Institute

Richmond, Australia

Eastern Health, Maroondah Hospital

Ringwood East, Australia

Breast Cancer Research Centre WA

Nedlands, Australia

Universit tsklinik Innsbruck

Innsbruck, Austria


Wien, Austria

Jessa Ziekenhuis

Hasselt, Belgium

AZ Nikolaas, Campus Moerland

Sint-Niklaas, Belgium

Vivalia St Joseph

Arlon, Belgium

AZ Klina

Brasschaat, Belgium

Hopital De Jolimont

Haine-St.- Paul, Belgium

AZ Groeninge

Kortrijk, Belgium

Clinique St Joseph

Liege, Belgium

H pital Civil Marie Curie

Lodelinsart, Belgium

Clinique Saint Pierre Ottignies

Ottignies, Belgium

Instituto do Cancer do Ceara

Fortaleza, Brazil

Funda o PIO XII

Barretos, Brazil

Hospital das Clinicas da FMRP

Ribeirao Preto, Brazil

INCA - Instituto Nacional Do Cancer

Rio De Janeiro, Brazil

The Ottawa Hospital

Ottawa, ON Canada

North York General Hospital

Toronto, ON Canada

Humber River Regional Hospital

Toronto, ON Canada

St Michaels Hospital

Toronto, ON Canada

Jewish General Hospital

Montreal, QC Canada

Henan Cancer Hospital

Zhengzhou, China

Beijing Tumor Hospital

Beijing, China

Shanghai Tumor Hospital

Shanghai, China

Nemocnice Horovice

Horovice, Czechia

Fakultni Nemocnice Ostrava

Ostrava, Czechia

Multiscan, s.r.o.

Pardubice, Czechia

FN Plzen Lochotin

Plzen, Czechia

Thomayerova Nemocnice

Praha 4 - Krc, Czechia

Fakultni Nemocnice v Motole

Praha 5, Czechia

Odense Universitetshospital

Odense C, Denmark

Herlev Hospital

Herlev, Denmark

Regionshospitalet Herning

Herning, Denmark

Nordsjaellands Hospital

Hillerod, Denmark

Vejle Sygehus

Vejle, Denmark

Kuopio University Hospital

Kuopio, Finland

Vaasa Central Hospital

Vaasa, Finland

Institut Sainte Catherine

Avignon Cedex 9, France

CHU de Besancon Hopital Jean Minjoz

Besancon Cedex, France

CHU Henri Mondor

Creteil Cedex, France

Centre Georges Francois Leclerc

Dijon Cedex, France

Polyclinique De Blois

La Chaussee Saint Victor, France

Clinique Victor Hugo

Le Mans, France

Centre Leon Berard

Lyon Cedex 08, France

Polyclinique de Gentilly

Nancy, France

Institut Curie

Paris CEDEX 05, France

Centre Eugene Marquis

Rennes Cedex, France

Centre Henri Becquerel

Rouen Cedex, France

Centre Ren Gauducheau

Saint Herblain Cedex, France

Universit tsklinikum Freiburg

Freiburg im Breisgau, Germany

Onkologische Schwerpunktpraxis

Freiburg im Breisgau, Germany

Praxis f r Onkologie

Friedrichshafen, Germany

Klinikum Ludwigsburg

Ludwigsburg, Germany

Universit tsklinikum Erlangen

Erlangen, Germany

Agaplesion Markus Krankenhaus

Frankfurt am Main, Germany

St dtische Kliniken Offenbach am Main

Offenbach am Main, Germany

HELIOS Klinikum Krefeld

Krefeld, Germany

Metropolitan Hospital

Neo Faliro, Greece

Ag. Savvas Hospital

Athens, Greece

Errikos Dynan

Athens, Greece

Attikon' University Hospital

Haidari/Athens, Greece

Queen Mary Hospital

Hong Kong, Hong Kong

Tuen Mun Hospital

Hong Kong, Hong Kong

Queen Elizabeth Hospital

Kowloon, Hong Kong

Bacs-Kiskun Megyei Korhaz

Kecskemet, Hungary

MNJ Institute of Oncology

Hyderabad, India

HCG Cancer Centre

Vadodara, India

Artemis Hospital

Gurgaon, India

Manipal Hospital

Bangalore, India

Regional Cancer Centre

Trivandrum, India

Tata Memorial Hospital

Mumbai, India

HCG Cancer Centre

Ahmedabad, India

Soroka Medical Center

Beer Sheva, Israel

Rambam Medical Center

Haifa, Israel

Shaare Zedek Medical Center

Jerusalem, Israel

Meir Medical Center

Kfar Saba, Israel

Rabin Medical Center

Petach Tikva, Israel

Sheba Medical Center

Ramat Gan, Israel

Kaplan Medical Center

Rehovot, Israel

Ospedale Perrino

Brindisi, Italy

Ospedale Bellaria

Bologna, Italy

Soonchunhyang University Hospital

Cheonan, Korea, Republic of

Seoul National University Bundang Hospital

Seongnam, Korea, Republic of

Gachon University Gil Medical Center

Incheon, Korea, Republic of

Samsung Medical Center

Seoul, Korea, Republic of

Korea University Guro Hospital

Seoul, Korea, Republic of

Asan Medical Center

Songpa-gu, Korea, Republic of

Ewha University Mokdong Hospital

Seoul, Korea, Republic of

Inje University Haeundae Paik Hospital

Busan, Korea, Republic of

Inha University Hospital

Incheon, Korea, Republic of

Korea University Anam Hospital

Seoul, Korea, Republic of

Seoul National University Hospital

Seoul, Korea, Republic of

CIMAB S.A. de C.V.

Torreon, Mexico

Centro Oncologico Internacional Guadalajara

Tlajomulco de Zuniga, Mexico

Consultorio Dr. Reinoso

Monterrey, Mexico

Oncol gica de Puebla

Puebla, Mexico

Onze Lieve Vrouwe Gasthuis (OLVG)

Amsterdam, Netherlands


Den Haag, Netherlands

Albert Schweitzer Ziekenhuis

Dordrecht, Netherlands

Universitair Medisch Centrum Maastricht

Maastricht, Netherlands

Palmerston North Hospital

Palmerston North, New Zealand

Auckland City Hospital

Auckland, New Zealand

Waikato Hospital

Hamilton, New Zealand

Hospital Fernando Fonseca

Amadora, Portugal

Funda o Champalimaud

Lisboa, Portugal

IPOFG - Porto

Porto, Portugal

University Of Puerto Rico

San Juan, Puerto Rico

SC Oncopremium Team SRL

Baia Mare, Romania

Spitalul Clinic Filantropia

Bucuresti, Romania

Kazan Oncology Dispensary

Kazan, Russian Federation

Chelyabinsk Regional Oncology Dispensary

Chelyabinsk, Russian Federation

SHI Kaluga Regional Hospital

Kaluga, Russian Federation

Kursk Regional Oncology Dispensary

Kursk, Russian Federation

Blokhin Cancer Research Center

Moscow, Russian Federation

Russian Oncological Research Center

Moscow, Russian Federation

Orenburg Regional Clinical Oncology Dispensary

Orenburg, Russian Federation

St. Petersburg City Clinical Oncological Dispensary

Saint-Petersburg, Russian Federation

FGU Research Institution of Oncology

St. Petersburg, Russian Federation

Volgograd regional clinical oncology dispensary

Volgograd, Russian Federation

King Fahad Medical City

Riyadh, Saudi Arabia

National Cancer Center

Singapore, Singapore

National University Hospital

Singapore, Singapore

The Medical Oncology Centre of Rosebank

Johannesburg, South Africa

UP- Steve Biko Hospital

Pretoria, South Africa

Eastleigh Breast Care Center

Pretoria, South Africa

Cancercare Rondebosch Oncology

Cape Town, South Africa


George, South Africa

Sandton Oncology Centre

Johannesburg, South Africa

Langenhoven Drive Oncology Centre

Port Elizabeth, South Africa

Mary Potter Oncology Center

Pretoria, South Africa

Hospital Clinico Universitario de Santiago

Santiago de Compostela, Spain

Hospital Universitario Quiron Madrid

Pozuelo de Alarcon, Spain

Hospital del Mar

Barcelona, Spain

Hospital Clinic I Provincial

Barcelona, Spain

Hospital Reina Sofia

Cordoba, Spain

Hospital De La Princesa

Madrid, Spain

L nssjukhuset Sundsvall

Sundsvall, Sweden

Changhua Christian Hospital

Changhua, Taiwan

Tri-Service General Hospital

Neihu Taipei, Taiwan

China Medical University Hospital

Taichung City, Taiwan

MacKay Memorial Hospital

Taipei City, Taiwan

Sun Yat-Sen Cancer Center

Taipei, Taiwan

Ankara University

Ankara, Turkey

Istanbul University

Istanbul, Turkey

ACINUS Medical and Diagnostic Center

Kropyvnytskyi, Ukraine

University Hospital of North Tees

Stockton-on-Tees, United Kingdom

Royal Cornwall Hospital

Truro, United Kingdom

Broomfield Hospital

Chelmsford, United Kingdom

North Middlesex Hospital

London, United Kingdom

Christie NHS Foundation Trust

Manchester, United Kingdom

Victoria Hospital

Blackpool, United Kingdom

Royal Preston Hospital

Preston, United Kingdom

Charing Cross Hospital

Chelsea, United Kingdom

Mount Vernon Hospital

Northwood, United Kingdom

Nottingham City Hospital

Nottingham, United Kingdom

Western General Hospital

Edinburgh, United Kingdom

Musgrove Park Hospital

Taunton, United Kingdom

Royal Surrey County Hospital

Guildford, United Kingdom

Guys/St. Thomas Hospital

London, United Kingdom

Sarah Canon Research Institute UK

London, United Kingdom

Royal Marsden Hospital

Sutton, United Kingdom

Airedale General Hospital

Keighley, United Kingdom

Pilgrim Hospital

Boston, United Kingdom

Churchill Hospital

Oxford, United Kingdom

Kaiser Permanente Medical Group

San Diego, CA United States

NCCA- National Cancer Care Alliance

Omaha, NE United States

Memorial Sloan Kettering Cancer Center

New York, NY United States

Riverina Cancer Care Centre

Wagga Wagga, Australia

Peter MacCallum Cancer Centre

Melbourne, Australia

Zhejiang Cancer Hospital

Hang Zhou, China

Soenderborg Sygehus

Soenderborg, Denmark

Centre Jean Perrin

Clermont Ferrand BP 392, France

Gen Onc Hosp Ag. Anargyroi

N. Kifissia, Greece

Interbalkan Medical Center

Pylaia/Thessaloniki, Greece

JCHO Kurume General Hosp

Kurume, Japan

Hiroshima University Hospital

Hiroshima-shi, Japan

University of tsukuba hospital

Tsukuba-shi, Japan

Tokai University Hospital

Isehara, Japan

Kanagawa Cancer Center

Yokohama, Japan

KKR Tohoku Kosai Hospital

Aoba-ku, Sendai-shi, Japan

Kindai University Hospital

Osaka Sayama-shi, Japan

Saitama Cancer Center

Kitaadachi-Gun, Japan

Shizuoka Cancer Center

Sunto-Gun, Japan

Tochigi Cancer Center

Utsunomiya, Japan

Juntendo University Hospital

Bunkyo-ku, Japan

Showa University Hospital

Shinagawa-ku, Japan

Chiba Cancer Center

Chiba, Japan

Kyushu Cancer Center

Fukuoka, Japan

Sagara Hospital

Kagoshima, Japan

Chungbuk National University Hospital

Cheong Ju-City, Korea, Republic of

Leningrad Regional Oncology Dispensary

Leningrad Region, Russian Federation

St. Joseph Hospital

Orange, CA United States

Columbia University

New York, NY United States

Northwest Cancer Specialists PC

Portland, OR United States

Universit tsklinikum Salzburg

Salzburg, Austria

National Cancer Center

Goyang-si, Korea, Republic of

Southern Cancer Center, P.C.

Daphne, AL United States

Orlando Health, Inc

Orlando, FL United States

Baptist Hospital

Pensacola, FL United States

NSABP Foundation

Pittsburgh, PA United States

Abington Memorial Hospital

Willow Grove, PA United States

Texas Oncology - McAllen

McAllen, TX United States

Rush University Medical Center

Chicago, IL United States

Virginia Commonwealth University

Richmond, VA United States

Clinica Onco Star

São Paulo, Brazil


København Ø, Denmark

N stved Sygehus

Næstved, Denmark

Keski-Suomen Keskussairaala

Jyväskylä, Finland

Universit tsklinikum T bingen

Tübingen, Germany

Franziskus-Hospital Harderberg

Georgsmarienhütte, Germany

Universit tsklinikum D sseldorf

Düsseldorf, Germany

Universit tsklinikum M nster

Münster, Germany

Centro de Estudios y Prevencion del Cancer

Tuxtla Gutiérrez, Mexico

Grupo M dico CAMINO S.C.

México City, Mexico

Oncol gico Potosino

San Luis Potosí, Mexico

Hospital Fundaci n Alcorc n

Alcorcón, Spain

V stmanlands sjukhus V ster s

Västerås, Sweden

V xj Centrallasarettet

Växjö, Sweden

Recruitment Status: Closed

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