Study to Assess Safety Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors

  • End date
    Jun 30, 2023
  • participants needed
  • sponsor
Updated on 25 June 2021


The primary objective of this study is to determine the safety and tolerability of pamiparib, the maximum tolerated dose (MTD) or maximum administered dose (MAD) for pamiparib combined with TMZ, to select the recommended Phase 2 dose (RP2D) and schedule of pamiparib in combination with TMZ, and to determine the antitumor activity of pamiparib in combination with TMZ.

Condition Locally Advanced or Metastatic Solid Tumors
Treatment Temozolomide, BGB-290, pamiparib
Clinical Study IdentifierNCT03150810
Last Modified on25 June 2021


Yes No Not Sure

Inclusion Criteria

Age 18 years old with advanced or metastatic stage solid tumors
Eastern Cooperative Oncology Group (ECOG) status 1 and measurable disease per RECIST V1.1 (except for participants in dose escalation and prostate cancer participants)
Additional inclusion criteria for dose expansion cohorts
Participants with homologous recombination deficiency (HRD+) or known BRCA
mutant Ovarian cancer
Previously received at least 1 line of platinum containing chemotherapy and No progression or recurrent disease in 6 months from last platinum containing regimen. Participants with HRD+ or known breast cancer susceptibility gene (BRCA) mutant Triple-Negative Breast Cancer
0 - 1 prior platinum-containing regimen (any treatment setting) and received 3 prior regimens (advanced or metastatic setting)
Participants with HRD+ or known BRCA mutant Prostate cancer
Chemotherapy-nave or previously received 2 taxane-based regimens
May have pre-or post-treatment with a novel androgen receptor targeted agent. Participants Small cell lung and gastric cancer
Previously received 2 prior lines of therapy. Participants with HRD+ NSCLC, head and neck cancer, esophageal cancer and soft tissue sarcomas
Must have tumors with with HRD+ as centrally determined
Must have received at least 1 but not more than 3 prior lines of therapy
Treatment nave patients with soft tissue sarcoma might be allowed if standard
of care therapy is not suitable or available

Exclusion Criteria

All participants
Prior exposure to a poly adenosine diphosphate-ribose polymerase (PARP) inhibitor
Refractory to platinum-based therapy
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note