The primary objective of this study is to determine the safety and tolerability of pamiparib, the maximum tolerated dose (MTD) or maximum administered dose (MAD) for pamiparib combined with TMZ, to select the recommended Phase 2 dose (RP2D) and schedule of pamiparib in combination with TMZ, and to determine the antitumor activity of pamiparib in combination with TMZ.
| Condition | Locally Advanced or Metastatic Solid Tumors |
|---|---|
| Treatment | Temozolomide, BGB-290, pamiparib |
| Clinical Study Identifier | NCT03150810 |
| Sponsor | BeiGene |
| Last Modified on | 28 April 2022 |
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