This is a randomized, placebo-controlled, double-blind study to evaluate the efficacy,
safety, and pharmacodynamics (PD) of multiple doses of REMD-477 in subjects who have Type 1
diabetes and are currently receiving insulin treatment. This study will determine whether
REMD-477 can decrease daily insulin requirements and improve glycemic control after 12 weeks
of treatment in subjects diagnosed with Type 1 diabetes with fasting C-peptide < 0.7 ng/mL at
The study will be conducted at multiple sites in the United States. Approximately 150
subjects with type 1 diabetes on stable doses of insulin will be randomized in a 1:1:1
fashion into one of three treatment groups.
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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