Last updated on April 2019

A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD)


Brief description of study

This randomized, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of crenezumab versus placebo in participants with prodromal to mild AD. Participants will be randomized 1:1 to receive either intravenous (IV) infusion of crenezumab or placebo every 4 weeks (q4w) for 100 weeks. The primary efficacy assessment will be performed at 105 weeks. The participants who do not enter open-label extension will enter for a long term follow-up period for up to 52 weeks after the last crenezumab dose (Week 153).

Clinical Study Identifier: NCT03114657

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Imaging End Points Clinical Research

Scottsdale, AZ United States

Radiant Research, Inc.

Tempe, AZ United States

University of Arizona

Tucson, AZ United States

Health Initiatives Research, PLLC

Fayetteville, AR United States

NEA Baptist Clinic

Jonesboro, AR United States

Clinical Trials Inc.

Little Rock, AR United States

ATP Clinical Research, Inc

Costa Mesa, CA United States

Senior Clinical Trials

Laguna Hills, CA United States

Uci Medical Center

Orange, CA United States

Neuro-Therapeutics Inc.

Pasadena, CA United States

Desert Valley Medical Group

Rancho Mirage, CA United States

Anderson Clinical Research, Inc.

Redlands, CA United States

Sharp Mesa Vista Hospital

San Diego, CA United States

UCSF - Memory and Aging Center

San Francisco, CA United States

MCB Clinical Research Centers

Colorado Springs, CO United States

Research Center for Clinical Studies, Inc.

Norwalk, CT United States

JEM Research LLC

Atlantis, FL United States

Bradenton Research Center

Bradenton, FL United States

University of Florida

Gainesville, FL United States

Alzheimer's Research and Treatment Center

Lake Worth, FL United States

Mount Sinai Medical Center

Miami Beach, FL United States

Renstar Medical Research

Ocala, FL United States

Neurology Associates Of Ormond Beach

Ormond Beach, FL United States

Progressive Medical Research

Port Orange, FL United States

Meridien Research

Saint Petersburg, FL United States

Suncoast Neuroscience Associates, Inc

Saint Petersburg, FL United States

Augusta University

Augusta, GA United States

Columbus Memory Center

Columbus, GA United States

Hawaii Pacific Neuroscience

Honolulu, HI United States

Advanced Clinical Research

Meridian, ID United States

Southern Illinois University, School of Medicine

Springfield, IL United States

Cotton O'Neil Clinical Research Center

Topeka, KS United States

Pennington Biomedical Research Center

Baton Rouge, LA United States

Lake Charles Clinical Trials, LLC

Lake Charles, LA United States

McLean Hospital; First Episode Clinic

Belmont, MA United States

Alzheimers Disease Center; Neurology

Winchester, MA United States

Precise Research Centers

Flowood, MS United States

University of Mississippi Medical Center

Jackson, MS United States

Pyramid Clinical Research

Monroe, NJ United States

The Cognitive and Research Center of New Jersey

Springfield, NJ United States

Advanced Memory Research Institute of NJ

Toms River, NJ United States

The Regents of the University of New Mexico

Albuquerque, NM United States

Richmond Behavioral Associates

Staten Island, NY United States

Behavioral Health Research

Charlotte, NC United States

Guilford Neurologic Associates

Greensboro, NC United States

Wake Research Associates

Raleigh, NC United States

Ohio Clinical Research Partners, LLC

Canton, OH United States

Dayton Center for Neuro Disorders

Centerville, OH United States

Ohio State University; College of Medicine

Columbus, OH United States

MDH Research LLC

Westerville, OH United States

Ips Research Company

Oklahoma City, OK United States

Summit Research Network Inc.

Portland, OR United States

Keystone Clinical Studies, LLC

Norristown, PA United States

Thomas Jefferson University

Philadelphia, PA United States

Northeastern Pennsylvania Memory

Plains, PA United States

Abington Neurological Associates

Willow Grove, PA United States

Neurology Clinic PC

Cordova, TN United States

Senior Adults Specialty Research

Austin, TX United States

Gadolin Research, LLC

Beaumont, TX United States

Texas Neurology PA

Dallas, TX United States

Texas Alzheimer's and Memory Disorders

Dallas, TX United States

InSite Clinical Research

DeSoto, TX United States

Clinical Trials of Texas, Inc

San Antonio, TX United States

Sentara Medical Group

Norfolk, VA United States

National Clinical Research Inc.-Richmond

Richmond, VA United States

Frontier Institute

Spokane, WA United States

Marshall Health

Huntington, WV United States

Hospital Italiano

Buenos Aires, Argentina

Universidad Maimonides

Caba, Argentina

Hospital Sirio Libanes

Caba, Argentina

St Vincent's Hospital Sydney

Darlinghurst, Australia

AZ Sint Jan

Brugge, Belgium

UZ Leuven Gasthuisberg

Leuven, Belgium

CCBR - Brasilia

Brasilia, Brazil

Hospital das Clinicas - UFMG

Belo Horizonte, Brazil

Hospital das Clinicas - UFRGS

Porto Alegre, Brazil

Hospital Mae de Deus

Porto Alegre, Brazil

University of Calgary

Calgary, AB Canada

Okanagan Clinical Trials

Kelowna, BC Canada

Vancouver Island Health Authority

Victoria, BC Canada

Jbn Medical Diagnostic Services Inc.

Burlington, ON Canada

The Centre for Memory and Aging

Toronto, ON Canada

St. Michael's Hospital

Toronto, ON Canada

Clinique NeuroOutaouais

Gatineau, QC Canada

Clinique Neuro Rive-Sud

Greenfield Park, QC Canada

ALPHA Recherche Clinique

Quebec, QC Canada

Laane-Tallinna Keskhaigla

Tallinn, Estonia

Hopital Broca

Paris, France

H pital Maison Blanche

Reims, France

CHU Rennes - Hopital Pontchaillou

Rennes cedex 09, France

Hopital des Charpennes

Villeurbanne, France

Clinica Humanamente

Ciudad de Guatemala, Guatemala

Nucare

Ciudad Guatemala, Guatemala

Pest Megyei Flor Ferenc Korhaz

Kistarcsa, Hungary

Rambam Medical Center

Haifa, Israel

Dong-A University Hospital

Busan, Korea, Republic of

Seoul National University Bundang Hospital

Gyeonggi-do, Korea, Republic of

Gachon University Gil Medical Center

Incheon, Korea, Republic of

Seoul National University Hospital

Seoul, Korea, Republic of

Hanyang University Seoul Hospital

Seoul, Korea, Republic of

Konkuk University Medical Center

Seoul, Korea, Republic of

Asan Medical Center

Seoul, Korea, Republic of

Samsung Medical Center

Seoul, Korea, Republic of

Seoul St Mary's Hospital

Seoul, Korea, Republic of

Borame Medical Center

Seoul, Korea, Republic of

Hospital General de M xico

Mexico City, Mexico

NZOZ Dom Sue Ryder

Bydgoszcz, Poland

Columbia University Medical Center

New York, NY United States

Neuro-Pain Medical Center

Fresno, CA United States

IMMUNOe Research Centers

Centennial, CO United States

Yale University School Of Medicine

New Haven, CT United States

Georgetown University Hospital

Washington, WA United States

Burke Rehabilitation Hospital

White Plains, NY United States

Devonshire Clinical Research Inc.

Woodstock, ON Canada

Beijing Union Hospital

Beijing, China

Tianjin Huanhu Hospital

Tianjin City, China

Fukuoka Mirai Hospital

Fukuoka, Japan

Tsukazaki Hospital

Hyogo, Japan

Yokohama General Hospital

Kanagawa, Japan

Fujisawa City Hospital

Kanagawa, Japan

Saigata Medical Center

Niigata, Japan

Katayama Medical Clinic

Okayama, Japan

AMC Nishi Umeda Clinic

Osaka, Japan

Ebara Hospital

Tokyo, Japan

Kanto Central Hospital

Tokyo, Japan

Bioclinica Research

Orlando, FL United States

DAMIC

Cordoba, Argentina

AZ Groeninge

Kortrijk, Belgium

Recruitment Status: Closed


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