Last updated on November 2018

Bortezomib Selinexor and Dexamethasone in Patients With Multiple Myeloma


Brief description of study

This Phase 3, 2-arm, randomized, active comparator-controlled, open-label, multicenter study will compare the efficacy and health-related quality of life (HR-QoL) and assess the safety of selinexor plus bortezomib (Velcade) plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with RRMM who have received 1 to 3 prior anti-multiple myeloma (MM) regimens. Crossover from the Vd Arm to a treatment that includes selinexor (i.e., SVdX or SdX) will be allowed at the point of IRC-confirmed objective disease progression per the IMWG criteria for patients in the Vd Arm.

Clinical Study Identifier: NCT03110562

Find a site near you

Start Over

The Alfred Hospital

Melbourne, Australia
  Connect »

UCL Saint-Luc

Brussels, Belgium
  Connect »

University of Cincinnati Health

Cincinnati, OH United States
  Connect »

McFarland Clinic

Ames, IA United States
  Connect »

L'H tel-Dieu de Qu bec

Quebec City, QC Canada
  Connect »

University of Maryland

Baltimore, MD United States
  Connect »

Prairie Lakes Healthcare

Watertown, SD United States
  Connect »

Flinders Medical Centre

Bedford Park, Australia
  Connect »

Novant-Forsyth Memorial Hospital

Winston-Salem, NC United States
  Connect »

Mount Sinai

New York, NY United States
  Connect »

Central Care Cancer Center

Bolivar, MO United States
  Connect »

Commonwealth Hematology

Danville, KY United States
  Connect »

Regional Cancer Centre

Thiruvananthapuram, India
  Connect »

Emory University

Atlanta, GA United States
  Connect »

Norton Cancer Institute

Louisville, KY United States
  Connect »

Kaiser Permanente Hawaii

Honolulu, HI United States
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.