Last updated on December 2018

Study of LN-145 Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma


Brief description of study

Prospective, multicenter, single-arm, open label, interventional study evaluating adoptive cell therapy (ACT) with autologous tumor infiltrating lymphocytes (TIL) infusion (LN-145) followed by IL-2 after a non-myeloablative (NMA) lymphodepletion preparative regimen for the treatment of patients with recurrent, metastatic, or persistent cervical carcinoma

Detailed Study Description

LN-145 is an adoptive cell transfer therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI, for the treatment of patients with recurrent, metastatic, or persistent cervical carcinoma. The cell transfer therapy used in this study involves patients receiving a NMA lymphocyte depleting preparative regimen, followed by infusion of autologous TIL followed by the administration of a regimen of IL-2.

Clinical Study Identifier: NCT03108495

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St. Joseph's Hospital and Medical Center Center For Women's Health
Phoenix, AZ United States
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University of Southern California
Los Angeles, CA United States
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Sylvester Comprehensive Cancer Center
Miami, FL United States
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University of Florida Health Cancer Center
Orlando, FL United States
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University of South Florida H. Lee Moffitt Cancer Center and Research Institute
Tampa, FL United States
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Augusta University
Augusta, GA United States
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University of Chicago
Chicago, IL United States
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James Graham Brown Cancer Center
Louisville, KY United States
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LSU Health Sciences Center
New Orleans, LA United States
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Stephanie Gaillard, Dr.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, MD United States
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Robert Morris, Dr.

Karmanos Cancer Institute
Detroit, MI United States
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Roswell Park Cancer Institute
Buffalo, NY United States
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The Ohio State University Comprehensive Cancer Center
Cleveland, OH United States
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The Ohio State University Comprehensive Cancer Center
Columbus, OH United States
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UPMC Cancer Center
Pittsburgh, PA United States
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MD Anderson Cancer Center
Houston, TX United States
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Medical College of Wisconsin
Milwaukee, WI United States
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Gustave Roussy Cancer Campus
Villejuif Cedex, France
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Academisch Medisch Centrum
Amsterdam, Netherlands
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Cl nica Universidad de Navarra
Pamplona, Spain
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Hospital Universitari Vall d'Hebr n
Barcelona, Spain
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Institut Catal d'Oncologia
Barcelona, Spain
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Hospital General Universitario Gregorio Mara on
Madrid, Spain
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Hospital Universitario Madrid Sanchinarro
Madrid, Spain
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Centre Hospitalier Universitaire Vaudois Lausanne - Centre Pluridisciplinaire d'Oncologie
Lausanne, Switzerland
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Bristol Haematology and Oncology Centre
Bristol, United Kingdom
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Sarah Cannon Research Institute London
London, United Kingdom
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University of California San Diego
San Diego, CA United States
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Centre Hospitalier Lyon Sud
Pierre Bénite, France
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Recruitment Status: Open


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