Last updated on April 2019

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug

Brief description of study

This is a Phase 3 multicenter study that includes two periods. Period 1 is designed to compare the safety, tolerability, and efficacy of ABT-494 Dose A once daily (QD) and Dose B QD versus placebo and versus adalimumab every other week (eow) in participants with moderately to severely active Psoriatic Arthritis (PsA) and have an inadequate response to non-biologic DMARDs (DMARD-IR). Period 1 is also designed to compare the efficacy of ABT-494 Dose A QD and Dose B QD versus placebo for the prevention of structural progression. Period 2 evaluates the safety, tolerability and efficacy of ABT-494 Dose A QD and Dose B QD in participants with PsA who have completed Period 1.

Clinical Study Identifier: NCT03104400

Contact Investigators or Research Sites near you

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St. Jude Heritage /ID# 159980

Fullerton, CA United States
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Kotha and Kotha /ID# 159823

La Mesa, CA United States
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Millennium Research /ID# 159822

Ormond Beach, FL United States
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FL Med Clinic, PA /ID# 159992

Zephyrhills, FL United States
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OrthoIllinois /ID# 164546

Rockford, IL United States
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Graves Gilbert Clinic /ID# 161285

Bowling Green, KY United States
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Aa Mrc Llc /Id# 159846

Grand Blanc, MI United States
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Shores Rheumatology, PC /ID# 159889

Saint Clair Shores, MI United States
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Clinvest Research LLC /ID# 161227

Springfield, MO United States
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Physicians East, PA /ID# 159872

Greenville, NC United States
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Health Research Oklahoma /ID# 159880

Oklahoma City, OK United States
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PA Regional Center /ID# 165670

Wyomissing, PA United States
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West Virginia Research Inst /ID# 159791

South Charleston, WV United States
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Instituto CAICI /ID# 160119

Rosario, Santa FE, Argentina
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Centro Integral de Medicina Re /ID# 160258

SAN Miguel DE Tucuman, Latam, Argentina
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Ciads /Id# 157831

Winnipeg, MB Canada
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PCCR Solution /ID# 205723

Grapevine, TX United States
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Recruitment Status: Open

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