Last updated on April 2019

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug


Brief description of study

This is a Phase 3 multicenter study that includes two periods. Period 1 is designed to compare the safety, tolerability, and efficacy of ABT-494 Dose A once daily (QD) and Dose B QD versus placebo and versus adalimumab every other week (eow) in participants with moderately to severely active Psoriatic Arthritis (PsA) and have an inadequate response to non-biologic DMARDs (DMARD-IR). Period 1 is also designed to compare the efficacy of ABT-494 Dose A QD and Dose B QD versus placebo for the prevention of structural progression. Period 2 evaluates the safety, tolerability and efficacy of ABT-494 Dose A QD and Dose B QD in participants with PsA who have completed Period 1.

Clinical Study Identifier: NCT03104400

Contact Investigators or Research Sites near you

Start Over

St. Jude Heritage /ID# 159980

Fullerton, CA United States
  Connect »

Kotha and Kotha /ID# 159823

La Mesa, CA United States
  Connect »

Millennium Research /ID# 159822

Ormond Beach, FL United States
  Connect »

FL Med Clinic, PA /ID# 159992

Zephyrhills, FL United States
  Connect »

OrthoIllinois /ID# 164546

Rockford, IL United States
  Connect »

Graves Gilbert Clinic /ID# 161285

Bowling Green, KY United States
  Connect »

Aa Mrc Llc /Id# 159846

Grand Blanc, MI United States
  Connect »

Shores Rheumatology, PC /ID# 159889

Saint Clair Shores, MI United States
  Connect »

Clinvest Research LLC /ID# 161227

Springfield, MO United States
  Connect »

Physicians East, PA /ID# 159872

Greenville, NC United States
  Connect »

Health Research Oklahoma /ID# 159880

Oklahoma City, OK United States
  Connect »

PA Regional Center /ID# 165670

Wyomissing, PA United States
  Connect »

West Virginia Research Inst /ID# 159791

South Charleston, WV United States
  Connect »

Instituto CAICI /ID# 160119

Rosario, Santa FE, Argentina
  Connect »

Centro Integral de Medicina Re /ID# 160258

SAN Miguel DE Tucuman, Latam, Argentina
  Connect »

Ciads /Id# 157831

Winnipeg, MB Canada
  Connect »

PCCR Solution /ID# 205723

Grapevine, TX United States
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.