CAR-T Therapy for Central Nervous System B-cell Acute Lymphocytic Leukemia

  • End date
    Feb 18, 2024
  • participants needed
  • sponsor
    Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd
Updated on 3 June 2022


This study will evaluates the safety and efficacy of Chimeric antigen receptor T cells (CAR-T) in treating central nervous system B-cell acute lymphocytic leukemia.


CNS leukemia is defined as unequivocal evidence of leukemic blasts in the cerebrospinal fluid by cytology or flow cytometry; cranial palsies or a nonhemorrhagic mass seen in cranial computed tomography or magnetic resonance imaging because of infiltration by leukemia cells

Condition B-cell Acute Lymphocytic Leukemia
Treatment CD19 CAR-T cells
Clinical Study IdentifierNCT03064269
SponsorShanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd
Last Modified on3 June 2022


Yes No Not Sure

Inclusion Criteria

Patients with CD19 positive central nervous system B-cell acute lymphocytic leukemia
ALT/ AST 《 3x normal
Creatinine 《 3x normal
Signed informed consent

Exclusion Criteria

Active hepatitis B , hepatitis C or HIV infection
Uncontrolled active infection
Pregnancy or breast-feeding women
Survival less than four weeks
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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