Last updated on February 2019

Study of Pembrolizumab (MK-3475) or Placebo Given With Best Supportive Care in Asian Participants With Previously Treated Advanced Hepatocellular Carcinoma (MK-3475-394/KEYNOTE-394)


Brief description of study

The purpose of this study is to determine the efficacy and safety of pembrolizumab or placebo given with best supportive care (BSC) in Asian participants with previously systemically treated advanced hepatocellular carcinoma (HCC). The primary hypothesis of this study is that overall survival is prolonged in participants who receive pembrolizumab compared to those who receive placebo.

Clinical Study Identifier: NCT03062358

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Anhui Provincial Hospital ( Site 0032)
Hefei, China
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Fuzhou General Hospital of Nanjing Military Command ( Site 0019)
Fuzhou, China
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The First People s Hospital of Foshan ( Site 0033)
Foshan, China
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Wuhan Tongji Hospital ( Site 0021)
Wuhan, China
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Nantong Tumor Hospital ( Site 0028)
Nantong, China
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The First Hospital Of Jilin University ( Site 0001)
Chang Chun, China
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Jilin Province Cancer Hospital, Department of Chemotherapy ( Site 0002)
Changchun, China
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The First Affiated Hospital of Dalian Medical Universtiy ( Site 0022)
Dalian, China
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West China Hospital of Sichuan University ( Site 0030)
Chengdu, China
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Beijing Cancer Hospital ( Site 0010)
Beijing, China
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Bengbu Medical College First Affiliated Hospital ( Site 0020)
Bengbu, China
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Hunan Cancer Hospital ( Site 0027)
Changsha, China
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The Third Xiangya Hospital of Central South University ( Site 0026)
Changsha, China
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Guangdong General Hospital ( Site 0015)
Guangzhou, China
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Zhejiang Cancer Hospital ( Site 0011)
Hangzhou, China
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Harbin Medical University Cancer Hospital ( Site 0007)
Harbin, China
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The First Affiliated Hospital of Anhui Medical University ( Site 0005)
Hefei, China
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Jiangsu Cancer Hospital ( Site 0003)
Nanjing, China
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The 81st Hospital of PLA ( Site 0016)
Nanjing, China
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Fudan University Shanghai Cancer Center ( Site 0024)
Shanghai, China
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Renji Hosp,Shanghai Jiao Tong University School of Medicine ( Site 0017)
Shanghai, China
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Zhongshan Hospital Fudan University ( Site 0012)
Shanghai, China
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The First Affiliated Hospital of Soochow University ( Site 0025)
Suzhou, China
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Yangzhou No.1 People's Hospital ( Site 0023)
Yangzhou, China
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Pamela Youde Nethersole Eastern Hospital ( Site 0052)
Hong Kong, Hong Kong
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Hong Kong Sanatorium Hospital ( Site 0053)
Hong Kong, Hong Kong
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Princess Margaret Hospital. ( Site 0051)
Hong Kong, Hong Kong
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Asan Medical Center ( Site 0072)
Seoul., Korea, Republic of
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Samsung Medical Center ( Site 0071)
Seoul, Korea, Republic of
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Seoul National University Hospital ( Site 0074)
Seoul, Korea, Republic of
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Severance Hospital Yonsei University Health System ( Site 0073)
Seoul, Korea, Republic of
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Beacon International Specialist Centre ( Site 0092)
Petaling Jaya, Malaysia
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University Malaya Medical Centre ( Site 0091)
Kuala Lumpur, Malaysia
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Chia-Yi Chang Gung Memorial Hospital ( Site 0133)
Chiayi, Taiwan
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China Medical University Hospital. ( Site 0131)
Taichung, Taiwan
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National Cheng Kung University Hospital ( Site 0132)
Tainan, Taiwan
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The First affiliated Hospital Zhejing University ( Site 0034)
Hangzhou, China
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Hospital Universiti Kebangsaan Malaysia ( Site 0093)
Cheras, Malaysia
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The Second Affiliated Hospital of Anhui Medical University ( Site 0008)
Hefei, China
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The first affiliated Hospital of Xi an Jiaotong University ( Site 0014)
XI An, China
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Recruitment Status: Open


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