Last updated on December 2018

Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)


Brief description of study

The purpose of this randomized, open-label, 2-arm, Phase 3 study is to assess the assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic Small Cell Lung Cancer (SCLC) with high levels of delta-like protein 3 (DLL3) and who have first disease progression during or following front-line platinum-based chemotherapy.

Clinical Study Identifier: NCT03061812

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Clearview Cancer Institute /ID# 155873
Huntsville, AL United States

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University of South Alabama /ID# 158151
Mobile, AL United States

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Highlands Oncology Group /ID# 155902
Fayetteville, AR United States

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Carti /Id# 156982
Little Rock, AR United States

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Cedars-Sinai Medical Center /ID# 157102
Beverly Hills, CA United States

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Ucsd /Id# 156965
La Jolla, CA United States

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Los Angeles Hematology Oncolog /ID# 155879
Los Angeles, CA United States

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UC Davis Comp Cancer Ctr /ID# 157001
Sacramento, CA United States

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St Jude Hospital dba St Joseph /ID# 155899
Santa Rosa, CA United States

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Icri /Id# 157090
Whittier, CA United States

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Christiana Care Health Service /ID# 158171
Newark, DE United States

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Cancer Specialists /ID# 155828
Jacksonville, FL United States

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Georgia Cancer Center /ID# 160206
Atlanta, GA United States

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St. Luke's Mt States Tumor /ID# 164550
Meridian, ID United States

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NorthShore Univ HealthSystem /ID# 157054
Evanston, IL United States

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Ingalls Memorial Hosp /ID# 155871
Harvey, IL United States

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Goshen Center for Cancer Care /ID# 155946
Goshen, IN United States

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University of Louisville /ID# 155947
Louisville, KY United States

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Ochsner Clinic Foundation /ID# 160807
New Orleans, LA United States

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Beth Israel Deaconess Med Ctr /ID# 203386
Boston, MA United States

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Dana-Farber Cancer Institute /ID# 160210
Boston, MA United States

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Edward W. Sparrow Hosp Assn /ID# 157021
Lansing, MI United States

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Nebraska Hematology Oncology /ID# 155900
Lincoln, NE United States

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Gabrail Cancer Center Research /ID# 155920
Canton, OH United States

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Oregon Health and Science University /ID# 157055
Portland, OR United States

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UPMC Hillman Cancer Ctr /ID# 164403
Pittsburgh, PA United States

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Univ Medical Ctr Brackenridge /ID# 156967
Austin, TX United States

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UT Southwestern Medical Center /ID# 158150
Dallas, TX United States

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University of Vermont Medical Center /ID# 162317
Burlington, VT United States

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University of Washington /ID# 162626
Seattle, WA United States

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Medical Oncology Associates /ID# 156856
Spokane, WA United States

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West Virginia Univ School Med /ID# 155872
Morgantown, WV United States

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Blacktown Hospital /ID# 158907
Blacktown, Australia

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St George Hospital /ID# 158855
Kogarah, Australia

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Southern Medical Day Care Ctr /ID# 158853
Wollongong, Australia

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The Prince Charles Hospital /ID# 158897
Chermside, Australia

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Ballarat Health Service /ID# 158904
Ballarat, Australia

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Austin Hospital /ID# 158898
Heidelberg, Australia

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Belarus Cancer Center N.N. Alexandrov /ID# 159325
Lesnoy, Belarus

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Mogilev Reg. Oncologic dispe /ID# 159326
Mogilev, Belarus

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CHU Saint-Pierre /ID# 159521
Bruxelles, Belgium

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Grand H pital de Charleroi /ID# 158748
Charleroi, Belgium

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Cliniques universitaires Saint /ID# 158751
Brussels, Belgium

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Hopital de Jolimont /ID# 159755
Haine Saint Paul, Belgium

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UZ Leuven /ID# 158752
Leuven, Belgium

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CHU de Liege Sart Tilman /ID# 158753
Liege, Belgium

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CHU Charleroi (Vesale) /ID# 159756
Montigny-le-tilleul, Belgium

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Liga Norte Rio Grandense Cont. /ID# 159015
Natal, Brazil

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Hospital Sao Lucas da PUCRS /ID# 159669
Porto Alegre, Brazil

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Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159666
Sao Jose Do Rio Preto, Brazil

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Inca /Id# 159665
Rio de Janeiro, Brazil

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Cross Cancer Institute /ID# 159519
Edmonton, AB Canada

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Juravinski Cancer Clinic /ID# 159514
Hamilton, ON Canada

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Hopital Sacre Coeur Montreal /ID# 159515
Montreal, QC Canada

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CHU de Quebec-Universite Laval /ID# 159093
Quebec City, QC Canada

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Fujian Provincial Cancer Hospital /ID# 204863
Fuzhou, China

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Harbin Medical University Cancer Hospital /Id# 203123
Haerbin, China

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Hubei Cancer Hospital /ID# 202887
Wuhan, China

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Hunan Cancer Hospital /ID# 202796
Changsha, China

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Fudan University Shanghai Cancer Center /Id# 206016
Shanghai, China

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Yunnan Cancer Hospital /ID# 204912
Kunming, China

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Zhejiang Cancer hospital /ID# 204500
Hangzhou, China

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Beijing Cancer Hospital /ID# 202881
Beijing, China

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Fujian Medical Univ Union Hosp /ID# 204861
Fuzhou, China

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Jiangsu Province Hospital /ID# 205184
Nanjing, China

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4th Military Medical Universit /ID# 203985
Xi'an, China

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1st Affiliated Hosp of Zhengzh /ID# 203030
Zhengzhou, China

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Klinicki bolnicki centar Sestre milosrdnice /ID# 158811
Zagreb, Croatia

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Klinika za plucne bolesti Jordanovac /ID# 159502
Zagreb, Croatia

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Klinicki bolnicki centar Rijeka /ID# 159501
Rijeka, Croatia

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Thomayerova nemocnice /ID# 159061
Prague, Czechia

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Nemocnice Rudolfa a Stefanie /ID# 159652
Benesov, Czechia

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Nemocnice Horovice a.s. /ID# 161191
Horovice, Czechia

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Herlev Hospital /ID# 158049
Herlev, Denmark

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Odense Universitets Hospital /ID# 158050
Odense C, Denmark

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Rigshospitalet, Finsen Centre /ID# 158051
Copenhagen, Denmark

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Hopital Haut-L v que /ID# 160558
Pessac CEDEX, France

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Assis.Publique-Hopital Nord /ID# 160554
Marseille, France

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Centre Leon Berard /ID# 160561
Lyon CEDEX 08, France

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Centre Hosp Intercommunal /ID# 162684
Creteil, France

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Assistance Publique- Hopitaux /ID# 160552
Paris, France

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Hospital Pontchaillou /ID# 160555
Rennes, France

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KH Martha-Maria Halle Dolau /ID# 158796
Halle (Saale), Germany

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Evangelische Lungenklinik Berl /ID# 159168
Berlin, Germany

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Asklepios Fachkliniken M. Gaut /ID# 158791
Gauting, Germany

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Lungen Clinic Grosshansdorf /ID# 158770
Grosshansdorf, Germany

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Thoraxklinik Heidelberg gGmbH /ID# 159169
Heidelberg, Germany

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Klinikum Kassel /ID# 158788
Kassel, Germany

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Metropolitan Hospital /ID# 159162
Athens, Greece

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University Hospital of Ioannin /ID# 159163
Ioannina, Greece

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Euromedica General Clinic /ID# 159161
Thessaloniki, Greece

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Semmelweis Egyetem /ID# 161197
Budapest, Hungary

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Orszagos Koranyi Pulmonologiai /ID# 158967
Budapest, Hungary

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Debreceni Egyetem /ID# 161209
Debrecen, Hungary

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Petz Aladar Megyei Oktato Korh /ID# 158978
Gyor, Hungary

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Matrai Gyogyintezet /ID# 158979
Matrahaza, Hungary

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AUSL 8 Arezzo Ospedale San Don /ID# 160967
Arezzo, Italy

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Istituto Europeo di Oncologia /ID# 158942
Milan, Italy

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AO Univ San Luigi Gonzaga /ID# 158945
Orbassano, Italy

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Ospedale Santa Maria delle Cro /ID# 158940
Ravenna, Italy

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IFO Istituto Nazionale Tumori /ID# 158941
Rome, Italy

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Aichi Cancer Center Hospital /ID# 164975
Nagoya-shi, Japan

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National Cancer Ctr Hosp East /ID# 165726
Kashiwa-shi, Japan

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Kyushu University Hospital /ID# 165723
Fukuoka-shi, Japan

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Kurume University Hospital /ID# 164586
Kurume-shi, Japan

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Kanazawa University Hospital /ID# 165129
Kanazawa, Japan

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Yokohama City University Hospital /ID# 165748
Yokohama-shi, Japan

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Japanese Red Cross Okayama Hospital /ID# 165156
Okayama-shi, Japan

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Kansai Medical University Hospital /ID# 165055
Hirakata-shi, Japan

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Kinki University -Osakasayama Campus /ID# 166394
Osakasayama-shi, Japan

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Shizuoka cancer center /ID# 166466
Sunto-gun, Japan

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Tokushima University Hospital /ID# 165812
Tokushima-shi, Japan

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National Cancer Center Hospital /ID# 166768
Chuo-ku, Japan

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The Cancer Institute Hosp JFCR /ID# 166249
Koto-ku, Japan

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Showa University Hospital /ID# 165574
Shinagawa-ku, Japan

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Hyogo Cancer Center /ID# 165125
Akashi, Japan

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Osaka City General Hospital /ID# 165717
Osaka, Japan

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Hokkaido Cancer Center /ID# 165237
Sapporo, Japan

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Sendai Kousei Hospital /ID# 166061
Sendai, Japan

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Wakayama Medical University /ID# 166032
Wakayama, Japan

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Kanagawa Cardio Resp Center /ID# 164374
Yokohama, Japan

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Kanagawa Cancer Center /ID# 165816
Yokohama, Japan

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Dong-A University Hospital /ID# 159296
Busan, Korea, Republic of

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CHA Bundang Medical center, CHA University /ID# 204416
Seongnam-si, Korea, Republic of

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Chonnam National University Hospital /ID# 159294
Gwangju, Korea, Republic of

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Kyungpook National University Chilgok Hospital /ID# 159292
Daegu, Korea, Republic of

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Korea University Guro Hospital /ID# 159293
Seoul, Korea, Republic of

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Chungbuk National University /ID# 159291
Cheongju-si, Korea, Republic of

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Asan Medical Center /ID# 159290
Seoul, Korea, Republic of

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Pauls Stradins Clinical /ID# 158713
Riga, Latvia

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Riga East Clinical University /ID# 158714
Riga, Latvia

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Centro de Invest Clin Chapulte /ID# 161000
Morelia, Mexico

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Health Pharma Professional Res /ID# 160020
Mexico, Mexico

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Isala /ID# 158653
Zwolle, Netherlands

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Copernicus PL Sp. z o. o., WCO /ID# 160538
Gdansk, Poland

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Szpitale Pomorskie Sp. z o.o /ID# 160536
Gdynia, Poland

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Centro Hospitalar Lisboa Norte, EPE /ID# 158687
Lisbon, Portugal

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IPO Lisboa FG, EPE /ID# 158995
Lisboa, Portugal

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Hospital da Luz, SA /ID# 158996
Lisbon, Portugal

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Unidade Local Saude Matosinhos /ID# 158682
Matosinhos, Portugal

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Hospital CUF Porto /ID# 158685
Porto, Portugal

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IPO Porto FG, EPE /ID# 158686
Porto, Portugal

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S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 160847
Craiova, Romania

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Oncocenter Oncologie Clinica S /ID# 160848
Timisoara, Romania

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Spitalul Judetean de Urgenta A /ID# 160846
Alba, Romania

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Arkhangelsk clinical oncology /ID# 159309
Arkhangelsk, Russian Federation

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Kaluga Regional Clinical Oncol /ID# 160179
Kaluga, Russian Federation

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Clinical Onco Dispensary /ID# 159307
Omsk, Russian Federation

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PMI Euromedservice /ID# 159311
Pushkin, Russian Federation

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LLC Novaya Klinika /ID# 205539
Pyatigorsk, Russian Federation

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Smolensk Regional Onc Clin Dis /ID# 159314
Smolensk, Russian Federation

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LLC BioEq Ltd. /ID# 159310
St. Petersburg, Russian Federation

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N.N. Petrov Research Inst Onc /ID# 159312
St. Petersburg, Russian Federation

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Clinical Center of Nis /ID# 160059
NIS, Serbia

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Institut za onkologiju i radio /ID# 160058
Belgrade, Serbia

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Klinicki centar Srbije /ID# 160024
Belgrade, Serbia

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Institute For Pulmonary Diseas /ID# 158813
Sremska Kamenica, Serbia

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National University Hospital /ID# 158802
Singapore, Singapore

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National Cancer Ctr Singapore /ID# 158803
Singapore, Singapore

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Hosp. Sta Creu i Sant Pau /ID# 159028
Barcelona, Spain

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Hospital Clinic de Barcelona /ID# 159031
Barcelona, Spain

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Hosp. Gral. Univ. Gregorio Mar /ID# 159025
Madrid, Spain

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Hosp Univ Madrid Sanchinarro /ID# 159024
Madrid, Spain

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Hosp Clin Univ de Valencia /ID# 159027
Valencia, Spain

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Uppsala University Hospital /ID# 159050
Uppsala, Sweden

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National Cheng Kung University Hospital /ID# 158844
Tainan City, Taiwan

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National Taiwan University Hospital /ID# 158865
Taipei City, Taiwan

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Tri-Service General Hospital /ID# 158985
Taipei City, Taiwan

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Taichung Veterans General Hosp /ID# 158866
Taichung City, Taiwan

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Bobruysk Interdistrict Onco. /ID# 169394
Bobruisk, Belarus

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Associa o Hospital Beneficente S o Vicente de Paulo - Hospital S o Vicente de P /ID# 159668
Passo Fundo, Brazil

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Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159017
Barretos, Brazil

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UMHAT Tsaritsa Joanna - ISUL /ID# 159641
Sofia, Bulgaria

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UMHAT Sv. Ivan Rilski /ID# 159642
Sofia, Bulgaria

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Sir Run Run Shaw Hospital /ID# 206801
Hangzhou, China

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Jilin Cancer Hosptial /ID# 204059
Changchun, China

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The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 203758
Urumqi, China

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The First Affiliated Hospital,College of Medicine, Zhejiang University /ID# 203092
Hangzhou, China

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Zhongshan Hospital Fudan University /ID# 205518
Shanghai, China

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Henan Cancer Hospital /ID# 203984
Zhengzhou, Henan, China

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Henan Cancer Hospital /ID# 204638
Zhengzhou, Henan, China

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Krajska nemocnice Liberec a.s. /ID# 159653
Liberec, Czechia

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General Hospital of Chest Diseases of Athens "SOTIRIA" /ID# 159165
Athens, Greece

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Torokbalinti Tudogyogyintezet /ID# 207053
Budapest, Hungary

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Veszprem Megyei Tuedoegyogyint /ID# 162607
Farkasgyepu, Hungary

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National Hospital Organization Himeji Medical Center /ID# 165893
Himeji, Japan

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Matsusaka City Hospital /ID# 166126
Matsusaka-shi, MIE, Japan

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Yonsei University Health System, Severance Hospital /ID# 159288
Seodaemun-gu, Korea, Republic of

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Universitair Medisch Centrum Groningen /ID# 158088
Groningen, Netherlands

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National Medical Research Cntr /ID# 207436
Moscow, Russian Federation

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First Affiliated Hospital of Medical College of Xi'an Jiaotong University /ID# 203732
Xi'an, China

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Cisss Du Bas-Saint-Laurent Hopital Regional de Rimouski /Id# 208931
Rimouski, QC Canada

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Hopital Arnaud de Villeneuve /ID# 209301
Montpellier Cedex 5, France

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Nemocnice Na Plesi s.r.o. /ID# 161190
Nová Ves pod Pleší, Czechia

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Nouvel Hopital Civil (NHC) /ID# 209388
Strasbourg, France

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GCS IUCT - Oncopole /ID# 209389
Toulouse, France

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Klinik Loewenstein GmbH /ID# 159167
Löwenstein, Germany

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Instituto Nacional de Cancerol /ID# 171350
Ciudad de México, Mexico

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Ziekenhuis St. Jansdal /ID# 158652
Harderwijk, Netherlands

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Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 160537
Rzeszów, Poland

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Sahlgrenska US Gbg /ID# 159534
Göteborg, Sweden

Recruitment Status: Closed


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