Last updated on March 2019

Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)

Brief description of study

The purpose of this randomized, open-label, 2-arm, Phase 3 study is to assess the assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic Small Cell Lung Cancer (SCLC) with high levels of delta-like protein 3 (DLL3) and who have first disease progression during or following front-line platinum-based chemotherapy.

Clinical Study Identifier: NCT03061812

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Clearview Cancer Institute /ID# 155873

Huntsville, AL United States

University of South Alabama /ID# 158151

Mobile, AL United States

Highlands Oncology Group /ID# 155902

Fayetteville, AR United States

Carti /Id# 156982

Little Rock, AR United States

Cedars-Sinai Medical Center /ID# 157102

Beverly Hills, CA United States

Ucsd /Id# 156965

La Jolla, CA United States

Los Angeles Hematology Oncolog /ID# 155879

Los Angeles, CA United States

UC Davis Comp Cancer Ctr /ID# 157001

Sacramento, CA United States

St Jude Hospital dba St Joseph /ID# 155899

Santa Rosa, CA United States

Icri /Id# 157090

Whittier, CA United States

Cancer Specialists /ID# 155828

Jacksonville, FL United States

Georgia Cancer Center /ID# 160206

Atlanta, GA United States

St. Luke's Mt States Tumor /ID# 164550

Meridian, ID United States

NorthShore Univ HealthSystem /ID# 157054

Evanston, IL United States

Ingalls Memorial Hosp /ID# 155871

Harvey, IL United States

University of Louisville /ID# 155947

Louisville, KY United States

Ochsner Clinic Foundation /ID# 160807

New Orleans, LA United States

Dana-Farber Cancer Institute /ID# 160210

Boston, MA United States

Edward W. Sparrow Hosp Assn /ID# 157021

Lansing, MI United States

Nebraska Hematology Oncology /ID# 155900

Lincoln, NE United States

UPMC Hillman Cancer Ctr /ID# 164403

Pittsburgh, PA United States

University of Washington /ID# 162626

Seattle, WA United States

Medical Oncology Associates /ID# 156856

Spokane, WA United States

West Virginia Univ School Med /ID# 155872

Morgantown, WV United States

Blacktown Hospital /ID# 158907

Blacktown, Australia

St George Hospital /ID# 158855

Kogarah, Australia

Austin Hospital /ID# 158898

Heidelberg, Australia

CHU Saint-Pierre /ID# 159521

Bruxelles, Belgium

Hopital de Jolimont /ID# 159755

Haine Saint Paul, Belgium

UZ Leuven /ID# 158752

Leuven, Belgium

CHU Charleroi (Vesale) /ID# 159756

Montigny-le-tilleul, Belgium

Inca /Id# 159665

Rio de Janeiro, Brazil

Herlev Hospital /ID# 158049

Herlev, Denmark

Hopital Haut-L v que /ID# 160558

Pessac CEDEX, France

Centre Leon Berard /ID# 160561

Lyon CEDEX 08, France

Klinikum Kassel /ID# 158788

Kassel, Germany

Semmelweis Egyetem /ID# 161197

Budapest, Hungary

Debreceni Egyetem /ID# 161209

Debrecen, Hungary

Matrai Gyogyintezet /ID# 158979

Matrahaza, Hungary

Dong-A University Hospital /ID# 159296

Busan, Korea, Republic of

Korea University Guro Hospital /ID# 159293

Seoul, Korea, Republic of

Chungbuk National University /ID# 159291

Cheongju-si, Korea, Republic of

Asan Medical Center /ID# 159290

Seoul, Korea, Republic of

Isala /ID# 158653

Zwolle, Netherlands

Arkhangelsk clinical oncology /ID# 159309

Arkhangelsk, Russian Federation

Kaluga Regional Clinical Oncol /ID# 160179

Kaluga, Russian Federation

Clinical Onco Dispensary /ID# 159307

Omsk, Russian Federation

PMI Euromedservice /ID# 159311

Pushkin, Russian Federation

LLC Novaya Klinika /ID# 205539

Pyatigorsk, Russian Federation

Smolensk Regional Onc Clin Dis /ID# 159314

Smolensk, Russian Federation

LLC BioEq Ltd. /ID# 159310

St. Petersburg, Russian Federation

N.N. Petrov Research Inst Onc /ID# 159312

St. Petersburg, Russian Federation

Henan Cancer Hospital /ID# 203984

Zhengzhou, Henan, China

Henan Cancer Hospital /ID# 204638

Zhengzhou, Henan, China

Matsusaka City Hospital /ID# 166126

Matsusaka-shi, MIE, Japan

National Medical Research Cntr /ID# 207436

Moscow, Russian Federation

Hopital Arnaud de Villeneuve /ID# 209301

Montpellier Cedex 5, France

Nemocnice Na Plesi s.r.o. /ID# 161190

Nová Ves pod Pleší, Czechia

Instituto Nacional de Cancerol /ID# 171350

Ciudad de México, Mexico

Ziekenhuis St. Jansdal /ID# 158652

Harderwijk, Netherlands

Sahlgrenska US Gbg /ID# 159534

Göteborg, Sweden

Recruitment Status: Closed

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