PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas

  • STATUS
    Not Recruiting
  • End date
    Dec 30, 2021
  • participants needed
    300
  • sponsor
    CytomX Therapeutics
Updated on 23 January 2021
Investigator
Lori Carman
Primary Contact
PROCLAIM Investigative Site (6.3 mi away) Contact
+39 other location
lymphoma
solid tumour

Summary

The purpose of this first-in-human study of CX-072 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-072 administered intravenously (IV) as a single agent or in combination with ipilimumab or vemurafenib in adult subjects with advanced or recurrent solid tumors or lymphomas. PROCLAIM-CX-072: PRObody CLinical Assessment In Man CX-072 clinical trial

CX-072 is a Probody therapeutic directed against PD-L1 (programmed cell death ligand 1). Probody therapeutics are proteolytically-activatable antibodies (Abs) designed to widen the therapeutic index by minimizing drug interaction with normal tissue while retaining anti-tumor activity. Probody therapeutics are "masked" to attenuate binding to target in healthy tissue but can become "unmasked" in the tumor microenvironment by tumor-specific protease activity.

PROBODY is a trademark of CytomX Therapeutics, Inc.

Details
Condition Lymphoma, Lymphoma, Solid Tumor
Treatment Ipilimumab, Vemurafenib, CX-072
Clinical Study IdentifierNCT03013491
SponsorCytomX Therapeutics
Last Modified on23 January 2021

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