Last updated on February 2018

The Analysis of WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) Increased Yield of Barrett's Esophagus and Esophageal Dysplasia


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Gastroesophageal Reflux | Esophageal Dysplasia | BARRETT'S ESOPHAGUS | Esophagus Adenocarcinoma
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Both males and females at least 18 years of age undergoing EGD to evaluate signs or symptoms suggestive of upper gastrointestinal disease.
  2. Patients with known GERD undergoing a screening EGD with accompanying WATS3D biopsies and forceps biopsies.
  3. Patients with known BE undergoing a surveillance EGD with accompanying WATS3D biopsies and forceps biopsies.
  4. Patients with a known prior history (recent or remote) of dysplasia of either indefinite, low grade or high-grade, or intramucosal adenocarcinoma undergoing a surveillance EGD with accompanying WATS3D biopsies and forceps biopsies.
  5. Patients who have undergone radiofrequency ablation orcryoablation who are undergoing surveillance EGD with accompanying WATS3D biopsies and forceps biopsies will be included in the study. The results of this group of patients will be analyzed separately from patients undergoing screening and surveillance who have not been ablated.
  6. Institutional Review Board (IRB)-approved consent must be signed by patients to participate in this study.

Exclusion Criteria:

  1. Patients who on their initial evaluation have a visible highly suspicious lesion, such as a nodule or ulcer, (noted while undergoing endoscopy) that requires targeted biopsy will be excluded from the study.
  2. Patients who do not undergo both Forceps Biopsy and WATS3D biopsy of the esophagus. Subsequent endoscopic evaluation may include forceps biopsies alone, WATS3D biopsies alone, both forceps and WATS3D biopsies, or no biopsies.
  3. Patients with visible lesions that are either submucosal or covered with intact epithelium.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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