Last updated on December 2018

A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy


Brief description of study

This is a Phase IIa/b double-blind, placebo-controlled, randomized, parallel group, multicenter study to evaluate the safety and efficacy of RO7123520 as adjunctive therapy in participants with RA who are inadequately responding to standard-of-care (methotrexate and anti-TNF-alpha therapy). Part 1 of the study will evaluate safety. Part 2 will evaluate efficacy and safety. Part 3 will evaluate dose-ranging efficacy. Participants will have the option of continuing to the extension period of the study.

Clinical Study Identifier: NCT03001219

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Reference Study ID Number: BP39261 ...

Pinnacle Research Group; Llc, Central
Anniston, AL United States

Reference Study ID Number: BP39261 ...

Arizona Arthritis & Rheumatology Associates, P.C.
Glendale, AZ United States

Reference Study ID Number: BP39261 ...

Arizona Arthritis and Rheuma
Mesa, AZ United States

Reference Study ID Number: BP39261 ...

Arizona Arthritis & Rheumatology Research, PLLC
Phoenix, AZ United States

Reference Study ID Number: BP39261 ...

University of California San Diego
La Jolla, CA United States

Reference Study ID Number: BP39261 ...

Stanford hospital & Clinics; Investigational Drug Services
Stanford, CA United States

Reference Study ID Number: BP39261 ...

Omega Research Consultants LLC
DeBary, FL United States

Reference Study ID Number: BP39261 ...

San Marcus Research Clinic, Inc.
Hialeah, FL United States

Reference Study ID Number: BP39261 ...

Millenium Research
Ormond Beach, FL United States

Reference Study ID Number: BP39261 ...

Ochsner Clin Foundatn; Clin Res
Baton Rouge, LA United States

Reference Study ID Number: BP39261 ...

Clinical Pharmacology Study Group
Worcester, MA United States

Reference Study ID Number: BP39261 ...

Shores Rheumatology PC
Saint Clair Shores, MI United States

Reference Study ID Number: BP39261 ...

Jackson Arthritis Clinic
Flowood, MS United States

Reference Study ID Number: BP39261 ...

Arthritis & Osteoporosis Associates
Freehold, NJ United States

Reference Study ID Number: BP39261 ...

Paramount Medical Research
Middleburg Heights, OH United States

Reference Study ID Number: BP39261 ...

Oklahoma Center For Arthritis Therapy & Research
Tulsa, OK United States

Reference Study ID Number: BP39261 ...

Altoona Center For Clinical Research
Duncansville, PA United States

Reference Study ID Number: BP39261 ...

Columbia Arthritis Center (Partnership Practice)
Columbia, SC United States

Reference Study ID Number: BP39261 ...

West Tennessee Research Institute
Jackson, TN United States

Reference Study ID Number: BP39261 ...

Metroplex Clinical Research
Dallas, TX United States

Reference Study ID Number: BP39261 ...

Pioneer Research Solutions
Houston, TX United States

Reference Study ID Number: BP39261 ...

Southwest Rheumatology
Mesquite, TX United States

Reference Study ID Number: BP39261 ...

Organizaci n medica de Investi
Cap fed, Argentina

Reference Study ID Number: BP39261 ...

Centro de Investigaciones Reumatologicas y Osteologicas
Ciudad Autonoma de Buenos Aires, Argentina

Reference Study ID Number: BP39261 ...

Instituto de Asistencia Reumatologica Integral
San Fernando, Argentina

Reference Study ID Number: BP39261 ...

Cer San Juan
San Juan, Argentina

Reference Study ID Number: BP39261 ...

Centro Medico Privado de Reumatologia; Reumathology
San Miguel, Argentina

Reference Study ID Number: BP39261 ...

Medizinische Universit t Wien, Allgemeines Krankenhaus der Stadt Wien
Wien, Austria

Reference Study ID Number: BP39261 ...

Rheuma Zentrum Favoriten GmbH
Wien, Austria

Reference Study ID Number: BP39261 ...

Centro Integral de Reumatologia del Caribe SAS CIRCARIBE SAS
Barranquilla, Colombia

Reference Study ID Number: BP39261 ...

Riesgo de Fractura S.A.
Bogota D.C., Colombia

Reference Study ID Number: BP39261 ...

Centro de Investigacion en Reumatologia y Especialdades Medicas SAS. CIREEM
Bogota, Colombia

Reference Study ID Number: BP39261 ...

Fundaci n Instituto de Reumatolog a Fernando Chalem
Bogota, Colombia

Reference Study ID Number: BP39261 ...

Servimed S.A.S.
Bucaramanga, Colombia

Reference Study ID Number: BP39261 ...

Clinica de Artritis Temprana S.A.
Cali, Colombia

Reference Study ID Number: BP39261 ...

Revmatologicky Ustav
Praha, Czechia

Reference Study ID Number: BP39261 ...

MEDICAL PLUS, s.r.o.
Uherske Hradiste, Czechia

Reference Study ID Number: BP39261 ...

Charit Research Organisation GmbH
Berlin, Germany

Reference Study ID Number: BP39261 ...

Praxis Dres. Jung
Deggingen, Germany

Reference Study ID Number: BP39261 ...

Centro Clinico de Especialidades Medicas
Ciudad De Guatemala, Guatemala

Reference Study ID Number: BP39261 ...

Centro de Estudio y Tratamiento de Enfermedades Reumaticas
Guatemala, Guatemala

Reference Study ID Number: BP39261 ...

Clinica Privada de Reumatologia Dr. Henry Briones Alvarado
Guatemala, Guatemala

Reference Study ID Number: BP39261 ...

Centro Medico del Angel
Mexicali, Mexico

Reference Study ID Number: BP39261 ...

Centro de Investigacion del Noroeste SC
Tijuana, Mexico

Reference Study ID Number: BP39261 ...

Investigacion y Biomedicina de Chihuahua, Sociedad Civil
Chichuahua, Mexico

Reference Study ID Number: BP39261 ...

Centro Integral en Reumatolog a S.A. de C.V. (CIRSA)
Guadalajara, Mexico

Reference Study ID Number: BP39261 ...

Centro de Estudios de Investigacion Basica y Clinica SC
Guadalajara, Mexico

Reference Study ID Number: BP39261 ...

Centro M dico de las Am ricas
Merida, Mexico

Reference Study ID Number: BP39261 ...

Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara, Mexico

Reference Study ID Number: BP39261 ...

Javier Orozco Private Practice
Guadalajara, Mexico

Reference Study ID Number: BP39261 ...

Centro de Investigaci n; Artritis y Osteoporosis S.C.
Mexicali, Mexico

Reference Study ID Number: BP39261 ...

Hospital Angeles Lindavista
Mexico, Mexico

Reference Study ID Number: BP39261 ...

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Mexico

Reference Study ID Number: BP39261 ...

Policlinica Medica de Queretaro S.C.
Queretaro, Mexico

Reference Study ID Number: BP39261 ...

Hogar Cl nica San Juan de Dios
Arequipa, Peru

Reference Study ID Number: BP39261 ...

Hospital Nacional Almanzor Aguinaga Asenjo; Unidad De Investigacion Del Servicio De Oncologia Medica
Chiclayo, Peru

Reference Study ID Number: BP39261 ...

Hospital Guillermo Almenara Irigoyen Hospital Guillermo Almenara Irigoyen Hospital Guillermo Almen
La Victoria, Peru

Reference Study ID Number: BP39261 ...

Clinica Internacional Sede Lima
LIma, Peru

Reference Study ID Number: BP39261 ...

Hospital Nacional Edgardo Rebagliati Martins
Lima, Peru

Reference Study ID Number: BP39261 ...

ABK Reuma SRL- Medicentro BioCiencias
Lima, Peru

Reference Study ID Number: BP39261 ...

Clinica Internacional, Sede San Borja; Unidad de Investigacion de Cl nica Internacional
Lima, Peru

Reference Study ID Number: BP39261 ...

Niepubliczny Zak ad Opieki Zdrowotnej "Vesalius" Sp. z o.o.
Krakw, Poland

Reference Study ID Number: BP39261 ...

Medyczne Centrum Hetmanska
Poznan, Poland

Reference Study ID Number: BP39261 ...

Samodzielny Publiczny Szpital Kliniczny nr 1 im. prof.Tadeusza Sokolowskiego
Szczecin, Poland

Reference Study ID Number: BP39261 ...

Reumatika - Centrum Reumatologii Niepubliczny Zak ad Opieki Zdrowotnej
Warszawa, Poland

Reference Study ID Number: BP39261 ...

New Queen Elizabeth Hospital Birmingham
Birmingham, United Kingdom

Reference Study ID Number: BP39261 ...

Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom

Reference Study ID Number: BP39261 ...

Barts Hospital; Department of Rheumatology
London, United Kingdom

Reference Study ID Number: BP39261 ...

University College London Hospital
London, United Kingdom

Reference Study ID Number: BP39261 ...

Guys and St Thomas NHS Foundation Trust, Guys Hospital
London, United Kingdom

Reference Study ID Number: BP39261 ...

Manchester Royal Infirmary; Kellgren Centre for Rheumatology
Manchester, United Kingdom

Reference Study ID Number: BP39261 ...

Newcastle U. Medical School; Institute of Cellular Medicine
Newcastle, United Kingdom

Reference Study ID Number: BP39261 ...

University of Oxford, Botnar Research Centre
Oxford, United Kingdom

Reference Study ID Number: BP39261 ...

Instituto de Ginecolog a y Reproducci n
Lima, Peru

Reference Study ID Number: BP39261 ...

Hospital Universitario Marques de Valdecilla; Servicio de Reumatologia
Santander, Spain

Reference Study ID Number: BP39261 ...

Hospital Universitario 12 de Octubre
Madrid, Spain

Reference Study ID Number: BP39261 ...

Hospital Regional Universitario Carlos Haya; Servicio de Psiquiatria
Malaga, Spain

Reference Study ID Number: BP39261 ...

Hospital Universitario Reina Sof a; Servicio de Aparato Digestivo
Murcia, Spain

Reference Study ID Number: BP39261 ...

Lister Hospital; Rheumatology Dept
Stevenage, United Kingdom

Reference Study ID Number: BP39261 ...

Advanced Medical Research, LLC
Lakewood, CA United States

Reference Study ID Number: BP39261 ...

Ocean Rheumatology
Toms River, NJ United States

Reference Study ID Number: BP39261 ...

Albuquerque Clinical Trials
Albuquerque, NM United States

Reference Study ID Number: BP39261 ...

Saint Lawrence Health System; Rheumatology
Canton, NY United States

Reference Study ID Number: BP39261 ...

Adriana Pop-Moody MD Clinic PA
Corpus Christi, TX United States

Reference Study ID Number: BP39261 ...

Accurate Clinical Research
Houston, TX United States

Reference Study ID Number: BP39261 ...

Azienda Ospedaliero-Universitaria Policlinico S. Orsola Malpighi; U.O. Malattie Infettive
Bologna, Italy

Reference Study ID Number: BP39261 ...

Azienda Ospedaliero Universitaria Careggi - SOD Reumatologia
Firenze, Italy

Reference Study ID Number: BP39261 ...

Hospital de Basurto; Servicio de Reumatologia
Bilbao, Spain

Reference Study ID Number: BP39261 ...

Hospital Universitario de la Princesa; Servicio de Reumatologia
Madrid, Spain

Reference Study ID Number: BP39261 ...

Hospital General Universitario Gregorio Mara on; Servicio de Reumatolog a
Madrid, Spain

Reference Study ID Number: BP39261 ...

Glasgow Royal Infirmary
Glasgow, United Kingdom

Reference Study ID Number: BP39261 ...

Derriford Hospital
Plymouth, United Kingdom

Reference Study ID Number: BP39261 ...

Medvin Clinical Research
Covina, CA United States

Reference Study ID Number: BP39261 ...

Atlantic Coast Rheumatology
Toms River, NJ United States

Reference Study ID Number: BP39261 ...

Albuquerque Center For Rheumatology
Albuquerque, NM United States

Reference Study ID Number: BP39261 ...

Advanced Rheumatology & Arthritis Research Center
Wexford, PA United States

Reference Study ID Number: BP39261 ...

Accurate Clinical Research, Inc
Stafford, TX United States

Reference Study ID Number: BP39261 ...

Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele
Catania, Italy

Reference Study ID Number: BP39261 ...

Low Country Rheumatology, PA
Charleston, SC United States

Reference Study ID Number: BP39261 ...

Azienda Ospedaliera Citt della Salute e della Scienza di Torino; Radiology
Torino, Italy

Reference Study ID Number: BP39261 ...

Healthy Medical Center SAS
Zipaquirá, Colombia

Reference Study ID Number: BP39261 ...

Unidad de Atencion Medica e Investigacion en Salud (UNAMIS)
Mérida, Mexico

Reference Study ID Number: BP39261 ...

Complexo Hospitalario Universitario A Coru a; Servicio de Reumatolog a
A Coruña, Spain