Last updated on December 2018

A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis


Brief description of study

The aim of the trial is to assess the safety and efficacy of the orally-administered, selective complement C5a receptor inhibitor CCX168 (avacopan) in inducing and sustaining remission in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Detailed Study Description

Complement 5a and its receptor C5aR (CD88) are involved in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

This is a randomized, double-blind, active-controlled Phase 3 study to evaluate the safety and efficacy of the orally-administered, selective C5aR inhibitor CCX168 (avacopan) in inducing and sustaining remission in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treated concomitantly with Rituximab or Cyclophosphamide/Azathioprine.

Clinical Study Identifier: NCT02994927

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Huntsville, AL United States

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Phoenix, AZ United States

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Los Angeles, CA United States

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Aurora, CO United States

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Denver, CO United States

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Daytona Beach, FL United States

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Tampa, FL United States

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Meridian, ID United States

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Chicago, IL United States

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Indianapolis, IN United States

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Kansas City, KS United States

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Shreveport, LA United States

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Baltimore, MD United States

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Boston, MA United States

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Ann Arbor, MI United States

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Saint Louis, MO United States

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Great Neck, NY United States

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Mineola, NY United States

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New York, NY United States

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Rochester, NY United States

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Chapel Hill, NC United States

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Greenville, NC United States

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Winston-Salem, NC United States

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Cleveland, OH United States

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Columbus, OH United States

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Duncansville, PA United States

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Philadelphia, PA United States

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Pittsburgh, PA United States

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Providence, RI United States

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Charleston, SC United States

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Dallas, TX United States

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Houston, TX United States

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Seattle, WA United States

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Adelaide, Australia

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Auchenflower, Australia

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Brisbane, Australia

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Clayton, Australia

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Concord, Australia

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Heidelberg, Australia

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Nambour, Australia

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Randwick, Australia

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Southport, Australia

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St Leonards, Australia

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Westmead, Australia

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Woolloongabba, Australia

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Feldkirch, Austria

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Graz, Austria

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Innsbruck, Austria

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Antwerp, Belgium

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Brussels, Belgium

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Leuven, Belgium

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Calgary, Canada

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Greenfield Park, Canada

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Hamilton, Canada

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Sherbrooke, Canada

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Vancouver, Canada

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Olomouc, Czechia

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Praha, Czechia

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Aalborg, Denmark

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Aarhus, Denmark

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Copenhagen, Denmark

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Odense, Denmark

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Roskilde, Denmark

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Bordeaux, France

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Boulogne-sur-Mer, France

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Bron, France

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Caen, France

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Colmar, France

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Grenoble, France

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Marseille, France

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Metz, France

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Nantes, France

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Paris, France

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Toulouse, France

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Valenciennes, France

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Aachen, Germany

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Bad Bramstedt, Germany

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Berlin, Germany

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Cologne, Germany

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Dresden, Germany

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Essen, Germany

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Freiburg, Germany

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Fulda, Germany

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Hamburg, Germany

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Jena, Germany

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Kirchheim unter Teck, Germany

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Ludwigshafen, Germany

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Munich, Germany

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Villingen-Schwenningen, Germany

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Budapest, Hungary

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Debrecen, Hungary

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Cork, Ireland

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Dublin, Ireland

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Ancona, Italy

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Genova, Italy

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Milano, Italy

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Reggio Emilia, Italy

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Groningen, Netherlands

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Leiden, Netherlands

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Rotterdam, Netherlands

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Christchurch, New Zealand

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Grafton, New Zealand

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Nordbyhagen, Norway

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Badalona, Spain

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Barcelona, Spain

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Burela, Spain

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Madrid, Spain

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Lund, Sweden

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Stockholm, Sweden

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Uppsala, Sweden

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Basel, Switzerland

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Bern, Switzerland

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Fribourg, Switzerland

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Lausanne, Switzerland

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St. Gallen, Switzerland

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Aberdeen, United Kingdom

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Basildon, United Kingdom

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Birmingham, United Kingdom

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Bristol, United Kingdom

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Cambridge, United Kingdom

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Canterbury, United Kingdom

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Cardiff, United Kingdom

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Carshalton, United Kingdom

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Dorchester, United Kingdom

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Dudley, United Kingdom

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Exeter, United Kingdom

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Glasgow, United Kingdom

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Inverness, United Kingdom

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Kirkcaldy, United Kingdom

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Leicester, United Kingdom

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Liverpool, United Kingdom

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London, United Kingdom

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Manchester, United Kingdom

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Newcastle, United Kingdom

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Nottingham, United Kingdom

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Reading, United Kingdom

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Salford, United Kingdom

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Westcliff-on-Sea, United Kingdom

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Washington, WA United States

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Lexington, KY United States

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Salt Lake City, UT United States

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Saint Albans, Australia

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Toronto, Canada

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Tuebingen, Germany

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Parma, Italy

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Dunedin, New Zealand

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Takapuna, New Zealand

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Oslo, Norway

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Lleida, Spain

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Leeds, United Kingdom

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Oxford, United Kingdom

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Atlanta, GA United States

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Minneapolis, MN United States

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Nedlands, Australia

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Angers, France

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Brest, France

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Leipzig, Germany

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Mannheim, Germany

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Firenze, Italy

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Monza, Italy

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Torino, Italy

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Ishikawa, Japan

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Tokyo, Japan

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Aichi, Japan

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Akita, Japan

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Chiba, Japan

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Hiroshima, Japan

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Hokkaido, Japan

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Kagawa, Japan

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Kanagawa, Japan

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Kobe, Japan

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Miyazaki, Japan

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Nagoya, Japan

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Okayama, Japan

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Osaka, Japan

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Saitama, Japan

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Shimane, Japan

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Shizuoka, Japan

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Toyama, Japan

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Yokohama, Japan

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Liège, Belgium

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Montréal, Canada

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Québec, Canada

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Nîmes, France

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Hannöver, Germany

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Lübeck, Germany

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Tromsø, Norway

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San Sebastián, Spain

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Linköping, Sweden

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Örebro, Sweden

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Zürich, Switzerland

Recruitment Status: Closed


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