Last updated on December 2018

HuMax-AXL-ADC Safety Study in Patients With Solid Tumors

Brief description of study

The purpose of the trial is to determine the maximum tolerated dose and to establish the safety profile of HuMax-AXL-ADC in a mixed population of patients with specified solid tumors

Detailed Study Description

The trial consists of two parts; a dose escalation part (phase I, first in- human (FIH)) and an expansion part (phase IIa).

The dose escalation part has two dose escalation arms: the first arm investigates a once every 3 weeks (1Q3W) dosing schedule and the second arm investigates a three administrations over 4 weeks (3Q4W) dosing schedule.

The Expansion part of the trial will further explore the recommended phase 2 dose and dosing regimens of HuMax-AXL-ADC as determined in Part 1

Clinical Study Identifier: NCT02988817

Contact Investigators or Research Sites near you

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Ignace Vergote, Professor

Universitair Ziekenhuizen Leuven
Leuven, Belgium
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Ulrik Lassen, MD

Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmark
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Suresh Ramalingham, MD

Emory University School of Medicine, Winship Cancer Institute
Atlanta, GA United States
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Fiona Thistlethwaite, MD

The Christie NHS Foundation Trust Clinical Trials Unit
Manchester, United Kingdom
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Yvette Drew, MD

Sir Bobby Robson Clinical Trials Unit at the Northern Centre for Cancer Care, Freeman Hospital
Newcastle, United Kingdom
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Mahesh Seetharam, MD

Mayo Clinic Scottsdale
Phoenix, AZ United States
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Lyudmila Bazhenova, MD

UC San Diego Moores Cancer Center
La Jolla, CA United States
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Victor Villalobos, MD

University of Colorado Cancer Center
Aurora, CO United States
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Mario Sznol, MD

Yale University, Smilow Cancer Center at Yale New Haven Hospital
New Haven, CT United States
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Steven Attia, MD

Mayo Clinic Jacksonville
Jacksonville, FL United States
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Mohammed Milhem, MD

University of Iowa
Iowa City, IA United States
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Pasi Janne, MD

Dana-Farber Cancer Institute
Boston, MA United States
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Shirish Gadgeel, MD

University of Michigan Comprehensive Cancer Center
Ann Arbor, MI United States
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Aaron Mansfield, MD

Mayo Clinic Rochester
Rochester, MN United States
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Grace Dy, MD

Roswell Park Comprehensive Cancer Center
Buffalo, NY United States
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Luca Paoluzzi, MD

NYU Medical Center
New York, NY United States
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Mathew Ingham, MD

Herbert Irving Comprehensive Cancer Center
New York, NY United States
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Jennifer Choe, MD

Duke Cancer Institute
Durham, NC United States
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Sujana Movva, MD

Fox Chase Cancer Center
Philadelphia, PA United States
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James Strauss, MD

Mary Crowley Cancer Reearch Center
Dallas, TX United States
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Sarina Piha-Paul, MD

MD Anderson
Houston, TX United States
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Jonathan Whisenant, MD

Huntsman Cancer Institute
Salt Lake City, UT United States
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Ticiana Ticiana, MD

University of Wisconsin Carbone Cancer Center
Madison, WI United States
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Jean Francois Baurain, MD

Institut Roi Albert II - Cliniques Universitaires Saint Luc
Bruxelles, Belgium
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Lore Decoster, MD

Universitair Ziekenhuis Brussel - Oncologisch Centrum
Jette, Belgium
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Philip Debruyne, MD

Medische oncologie, Oncologisch Centrum - AZ Groeninge
Kortrijk, Belgium
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Patrick Schoffski, MD

U.Z. Leuven Gasthuisberg, Department of General Medical Oncology
Leuven, Belgium
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Guy Jerusalem, MD

CHU de Li ge, Medical Oncology et. Domaine Universitaire du Sart Tilman
Liege, Belgium
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Christian Blank, MD

The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
Amsterdam, Netherlands
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Andre Johan Gelderblom, MD

Leiden University Medical Centre
Leiden, Netherlands
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Lotje Devriese, MD

UMC Utrecht Cancer Center
Utrecht, Netherlands
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Heather Shaw, MD

Universtity College London Hospitals
London, United Kingdom
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Juanita Lopez, MD

The Royal Marsden NHS Foundation Trust
London, United Kingdom
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Recruitment Status: Open

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