Last updated on May 2019

Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors


Brief description of study

The purpose of the trial is to determine the maximum tolerated dose and to establish the safety profile of HuMax-AXL-ADC in a mixed population of patients with specified solid tumors

Detailed Study Description

The trial consists of two parts; a dose escalation part (phase I, first in- human (FIH)) and an expansion part (phase IIa).

The dose escalation part has two dose escalation arms: the first arm investigates a once every 3 weeks (1Q3W) dosing schedule and the second arm investigates a three administrations over 4 weeks (3Q4W) dosing schedule.

The Expansion part of the trial will further explore the recommended phase 2 dose and dosing regimens of HuMax-AXL-ADC as determined in Part 1

Clinical Study Identifier: NCT02988817

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Mayo Clinic Scottsdale

Phoenix, AZ United States
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Mayo Clinic Jacksonville

Jacksonville, FL United States
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University of Iowa

Iowa City, IA United States
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Mayo Clinic Rochester

Rochester, MN United States
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NYU Medical Center

New York, NY United States
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Duke Cancer Institute

Durham, NC United States
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Fox Chase Cancer Center

Philadelphia, PA United States
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MD Anderson

Houston, TX United States
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Huntsman Cancer Institute

Salt Lake City, UT United States
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Recruitment Status: Open


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