Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma

  • STATUS
    Recruiting
  • participants needed
    41
  • sponsor
    Georgetown University
Updated on 28 November 2021

Summary

This is a phase I/II study in which patients will be enrolled in a standard 3+3 design. Once the maximum tolerated dose (MTD) is determined amongst patients with relapsed or refractory grade 1-3a follicular lymphoma, there will be a 17-patient phase II study.

Description

In vitro studies of ibrutinib and venetoclax have noted significant cytotoxicity and synergy in mantle cell lymphoma and chronic lymphocytic leukemia cell lines.Data have demonstrated synergy between the two agents in various other B-cell Non-Hodgkin Lymphoma (NHL) cell lines. The investigators theorize that the combination of ibrutinib and venetoclax will provide dual, yet unique, targeted inhibition for patients with follicular lymphoma, resulting in both significant efficacy and less nonspecific toxicity.

Details
Condition Refractory Follicular Lymphoma, Relapsed Follicular Lymphoma
Treatment Ibrutinib, venetoclax
Clinical Study IdentifierNCT02956382
SponsorGeorgetown University
Last Modified on28 November 2021

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