Trial of Magrolimab (Hu5F9-G4) in Combination With Rituximab or Rituximab + Chemotherapy in Participants With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

  • STATUS
    Not Recruiting
  • End date
    Aug 15, 2026
  • participants needed
    422
  • sponsor
    Gilead Sciences
Updated on 27 June 2022
cancer
hodgkin's disease
rituximab
monoclonal antibodies
combination chemotherapy
gemcitabine
follicular lymphoma
diffuse large b-cell lymphoma
b-cell lymphoma
large b-cell lymphoma
indolent lymphoma

Summary

The primary objectives of this study are:

  • To investigate the safety and tolerability, and to define the recommended Phase 2 dose and schedule (RP2DS) for magrolimab in combination with rituximab and for magrolimab in combination with rituximab, gemcitabine, and oxaliplatin (R-GemOx).
  • To evaluate the efficacy of magrolimab in combination with rituximab in participants with indolent lymphoma and diffuse large B-cell lymphoma (DLBCL) and to evaluate the efficacy of magrolimab in combination with R-GemOx in aspartate aminotransferase (ASCT) ineligible DLBCL participants.

Details
Condition Non Hodgkin Lymphoma
Treatment Rituximab, gemcitabine hydrochloride, Gemcitabine, Oxaliplatin, Hu5F9-G4, Magrolimab
Clinical Study IdentifierNCT02953509
SponsorGilead Sciences
Last Modified on27 June 2022

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