Last updated on February 2018

French Registry of First-line Treatment of Acute Promyelocytic Leukemia


Brief description of study

The registry aims to compare the two first-line available treatment approaches in non-high-risk APL patients aged 70 years - ATRA plus chemotherapy and ATRA plus ATO - in terms of practitioner's choice between the two options, clinical effectiveness and cost-effectiveness, long-term outcome, and short- and long-term toxic effects.

Detailed Study Description

  • Collection of epidemiological data on non-high-risk APL patients aged 70 years: age and sex distribution, medical history, prognostic factors (time to treatment start, severity of coagulopathy at presentation, Performance status).
    • Documentation of clinical and biologic effectiveness of the two first-line treatment approaches available for non-high-risk APL patients.
    • Documentation of Minimal Residual Disease (MRD).
    • Correlation of clinical outcomes with the chosen therapy.
    • Validation of published prognostic factors and identification of new prognostic factors

Clinical Study Identifier: NCT02938858

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Sylvie CAILLERES, MD

Centre Hospitalier d'Aix en Provence
Aix en Provence, France
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Delphine LEBON, MD

Groupe Hospitalier SUD
Amiens, France
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Ahmad ALJIJAKLI, MD

Centre Hospitalier V. Dupouy
Argenteuil, France
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Charlotte JUBERT, MD

CHU Bordeaux Pellegrin enfant
Bordeaux, France
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Liana CARAUSU, MD

CHRU de Brest - P diatrie Sp cialis e
Brest, France
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Victoria CACHEUX, MD

CHU Estaing
Clermont-Ferrand, France
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Martin CARRE, MD

CHU de Grenoble
Grenoble, France
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Anne-Laure TAKSIN, MD

Hopital Andre Mignot
Le Chesnay, France
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Brigitte DUPRIEZ, MD

CH Dr Schaffner
Lens, France
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Céline BERTHON, MD

Chru - Hopital Claude Huriez
Lille, France
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Marie-Pierre GOURIN, MD

H pital universitaire Dupuytren
Limoges, France
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Norbert VEY, MD

Institut Paoli Calmettes
Marseille, France
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Gérard MICHEL, MD

Chu Timone
Marseille, France
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Houria DEBARRI, MD

CHR Metz-Thionville - H pital de Marcy
Metz, France
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Yosr HICHERI, MD

CHU Saint Eloi
Montpellier, France
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Pierre PETERLIN, MD

CHU H tel Dieu
Nantes, France
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Jean DONADIEU, MD

H pital TROUSSEAU
Paris, France
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Ambroise MARCAIS, MD

H pital Necker
Paris, France
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Benoit BRETHON, MD

H pital Robert Debr
Paris, France
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Virginie GANDEMER, MD

CHU H pital Sud - service H mato-oncologie P diatrique
Rennes, France
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Isabelle DERVITE, MD

H pital V. Provo
Roubaix, France
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Aspasia STAMATOULLAS, MD

Centre Henri Becquerel
Rouen, France
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Emmanuelle TAVERNIER, MD

Institut de Cancerologie de La Loire
Saint Priest-en-jarez, France
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Christian RECHER, MD

IUCT Oncopole
Toulouse, France
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Fabrice LAROSA, MD

H pital Jean Minjoz
Besançon, France
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Florence BECKERICH, MD

H pital Henri Mondor
Créteil, France
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Diana CARP, MD

H pital de la Source
Orléans, France
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Recruitment Status: Open


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