Last updated on February 2018

Study Testing Radium-223 Dichloride in Relapsed Multiple Myeloma


Brief description of study

This study will be conducted in 2 parts. The phase 1b part will be an international, phase 1b, open-label, dose-escalation assessment of radium-223 dichloride administered with bortezomib and dexamethasone in subjects with relapsed multiple myeloma. The primary endpoint is to determine the optimal dose of radium-223 dichloride in combination with bortezomib/dexamethasone for the Phase 2 portion of the study. The phase 2 part will be an international, phase 2, double-blind, randomized, placebo-controlled assessment of radium-223 dichloride versus placebo administered with bortezomib and dexamethasone, in subjects with relapsed multiple myeloma. Up to approximately 30 total subjects in all dose cohorts combined will be treated in the phase 1b part of the study and approximately 196 subjects will be enrolled in the phase 2 part of the study.

Clinical Study Identifier: NCT02928029

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California Cancer Associates for Research & Excellence, Inc.
Fresno, CA United States
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National Cancer Center
Goyang-si, Korea, Republic of
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Kyungpook National University Hospital
Daegu, Korea, Republic of
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Chonnam National University Hwasun Hospital
Jeollanam-do, Korea, Republic of
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Seoul National University Hospital
Seoul, Korea, Republic of
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Samsung Medical Center
Seoul, Korea, Republic of
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Seoul St. Mary's Hospital
Seoul, Korea, Republic of
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Asan Medical Center
Seoul, Korea, Republic of
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Institut Catal d'Oncologia Badalona
Badalona, Spain
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Hospital Universitari Son Espases
Palma de Mallorca, Spain
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Ciutat Sanit ria i Universitaria de la Vall d'Hebron
Barcelona, Spain
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Hospital Universitario de la Princesa
Madrid, Spain
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Hospital Universitario Virgen del Roc o
Sevilla, Spain
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Hospital Universitario Dr. Peset
Valencia, Spain
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