Last updated on September 2018

The Circulating Cell-free Genome Atlas Study


Brief description of study

GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer participants and to develop models for distinguishing cancer from non-cancer.

Detailed Study Description

This is a prospective, multi-center, observational study with collection of de-identified biospecimens and clinical data from at least 15,000 participants from clinical networks in the United States and Canada. The study will enroll approximately 10,500 cancer participants (CANCER arm) and approximately 4,500 representative participants without a clinical diagnosis of cancer (NON-CANCER arm). Clinical information, demographics, and medical data relevant to cancer status are collected from all participants and their medical record at baseline (time of biospecimen collection), and subsequently from the medical record at intermittent future time points, at least annually for up to 5 years.

Clinical Study Identifier: NCT02889978

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Mayo Clinic - Arizona

Scottsdale, AZ United States
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Mercy Fort Smith

Fort Smith, AR United States
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Rocky Mountain Cancer Center

Colorado Springs, CO United States
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Rocky Mountain Cancer Center

Lakewood, CO United States
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Rocky Mountain Cancer Centers

Littleton, CO United States
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Rocky Mountain Cancer Centers

Lone Tree, CO United States
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Mayo Clinic - Florida

Jacksonville, FL United States
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Illinois Cancer Specialists

Arlington Heights, IL United States
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Baptist Health Lexington

Lexington, KY United States
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Baptist Health Louisville

Louisville, KY United States
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Baptist Health Paducah

Paducah, KY United States
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Maryland Oncology Hematology, P.A.

Silver Spring, MD United States
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Lahey Hospital & Medical Center

Burlington, MA United States
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Mercy Joplin

Joplin, MO United States
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Mercy Research - Springfield

Springfield, MO United States
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Broome Oncology, LLC

Binghamton, NY United States
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New York Oncology Hematology, P.C.

Clifton Park, NY United States
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Broome Oncology, LLC

Johnson City, NY United States
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Memorial Sloan Kettering

New York, NY United States
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Cleveland Clinic

Cleveland, OH United States
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Greenville Health System

Seneca, SC United States
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Avera Research Institute

Sioux Falls, SD United States
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Texas Oncology-Bedford

Bedford, TX United States
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Texas Oncology-Fort Worth

Fort Worth, TX United States
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Texas Oncology - McAllen

McAllen, TX United States
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Texas Oncology-New Braunfels

New Braunfels, TX United States
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Texas Oncology - Tyler

Tyler, TX United States
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Texas Oncology - Weslaco

Weslaco, TX United States
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Virginia Cancer Specialists, PC

Alexandria, VA United States
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Virginia Cancer Specialists, PC

Gainesville, VA United States
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Virginia Cancer Specialists, PC

Woodbridge, VA United States
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Sansum Clinic - 540

Santa Barbara, CA United States
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Sansum Clinic- 317

Santa Barbara, CA United States
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Sansum Clinic - Viborg

Solvang, CA United States
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Rocky Mountain Cancer Centers

Englewood, CO United States
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Hartford New Britain

New Britain, CT United States
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UMHC Sylvester- Coral Springs

Coral Springs, FL United States
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Mayo Clinic - Rochester

Rochester, MN United States
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Tennessee Oncology Memorial Plaza

Chattanooga, TN United States
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Tennessee Oncology CMC

Crossville, TN United States
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Tennessee Oncology Dickson

Dickson, TN United States
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Tennessee Oncology Franklin

Franklin, TN United States
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Tennessee Oncology Gallatin

Gallatin, TN United States
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Tennessee Oncology Summit

Hermitage, TN United States
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Tennessee Oncology Lebanon

Lebanon, TN United States
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Tennessee Oncology Murfreesboro

Murfreesboro, TN United States
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Tennessee Oncology Midtown

Nashville, TN United States
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Tennessee Oncology Nashville

Nashville, TN United States
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Tennessee Oncology SCCBC

Nashville, TN United States
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Tennessee Oncology Skyline

Nashville, TN United States
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Tennessee Oncology Shelbyville

Shelbyville, TN United States
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Texas Oncology - Grapevine

Grapevine, TX United States
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Texas Oncology - Mesquite

Mesquite, TX United States
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Texas Oncology - Rockwall

Rockwall, TX United States
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Texas Oncology - Sherman

Sherman, TX United States
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Texas Oncology-The Woodlands

The Woodlands, TX United States
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Texas Oncology - Wichita Falls

Wichita Falls, TX United States
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Recruitment Status: Open


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