Pipeline

July 12, 2021

Company	Drug/Device	Medical Condition	Status
Agenus Bristol Myers Squibb	AGEN1777	advanced solid tumors	IND approved by the FDA
Cullinan Oncology	CLN-619	solid and liquid tumors	IND approved by the FDA
Eucure Biopharma	YH001	advanced nonsmall-cell lung cancer and hepatocellular carcinoma	IND approved by the FDA for phase 2 trial
Eucure Biopharma	YH003	PD-1-resistant unresectable/metastatic melanoma and pancreatic ductal adenocarcinoma	IND approved by the FDA for phase 2 trial
HDT Bio	HDT-301 COVID-19 RNA vaccine	SARS-CoV-2 and variants	IND approved by the FDA
Immunic	IMU-838	relapsing-remitting multiple sclerosis	IND approved by the FDA for phase 3 trial
Immunic	IMU-838	progressive multiple sclerosis	IND approved by the FDA for phase 2 trial
Sirnaomics	STP707	advanced solid tumors	IND approved by the FDA
Sorrento Therapeutics	Resiniferatoxin (RTX)	moderate-to-severe pain from osteoarthritis of the knee	IND approved by the FDA for phase 2 trial
Vect-Horus RadioMedix	68Ga-RMX-VH	glioblastoma multiforme diagnostic	exploratory IND approved by the FDA
Antengene	selinexor	myelofibrosis	IND approved by China's National Medical Products Administration
SciSparc	SCI-110	Alzheimer's disease and agitation	approval received from the Israeli Ministry of Health and Helsinki Committee for a phase 2a trial
CytoSorbents	ticagrelor	cardiopulmonary bypass circuit during cardiothoracic surgery	IDE approved by the FDA
Genentech	intravenous Actemra (tocilizumab)	COVID-19 in hospitalized adults and pediatric patients (two years of age and older) who are receiving systemic corticosteroids and require supplemental oxygen, noninvasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation	Emergency Use Authorization granted by the FDA
Galderma	Restylane Contour	cheek augmentation and midface contour deficiencies	approved by the FDA
Jazz Pharmaceuticals	Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn)	acute lymphoblastic leukemia or lymphoblastic lymphoma in pediatric and adult patients one month and older who have developed hypersensitivity to E. coli-derived asparaginase	approved by the FDA
Lupin Pharmaceuticals	Solosec (secnidazole)	trichomoniasis vaginalis	approved by the FDA for expanded indication
Merck	Keytruda (pembrolizumab)	patients with locally advanced cutaneous squamous-cell carcinoma that is not curable by surgery or radiation	approved by the FDA for expanded indication
Siemens Healthineers	Magnetom Free.Max 80 cm	lightweight magnetic resonance scanner	cleared for marketing by the FDA
Bristol Myers Squibb	Opdivo (nivolumab) plus Yervoy (ipilimumab)	mismatch repair-deficient or microsatellite instability-high metastatic colorectal cancer after prior fluoropyrimidine-based combination chemotherapy	approved by the European Commission