Pipeline

November 8, 2019

Company	Drug/Device	Medical Condition	Status
BioCryst Pharmaceuticals, Inc.	BCX9250	fibrodysplasia ossificans progressive (FOP)	Phase 1 trial initiated enrolling healthy subjects
Revolution Medicines, Inc. Amgen	RMC-4630 in combination with AMG 510	advanced solid tumors	Phase 1b trial initiated enrolling subjects with advanced solid tumors harboring the KRASG12C mutation
X4 Pharmaceuticals, Inc.	X4P-001	Severe Congenital Neutropenia (SCN)	Phase 1b trial initiated enrolling 45 subjects with SCN and other selected congenital neutropenia disorders
CohBar, Inc.	CB4211	nonalcoholic steatohepatitis (NASH), NAFLD and obesity	Phase 1b trial initiated enrolling 20 obese subjects with NAFLD
Cartesian Therapeutics	Descartes-08	generalized myasthenia gravis (GMG)	Phase 1/2 trial initiated
Ichnos Sciences	ISC 27864	osteoarthritic pain	Phase 2b trial initiated enrolling 624 adult subjects with moderate osteoarthritic pain of the knee and/or hip at sites in India.
Ichnos Sciences	ISB 830	atopic dermatitis	Phase 2b trial initiated enrolling 312 adult subjects with moderate to severe atopic dermatitis at sites in the U.S., Canada and Europe
RhoVac AB	RV001	prostate cancer	Phase 2b trial initiated enrolling 175 subjects at multiple centers in Denmark, Finland, Sweden, United Kingdom, Belgium, Germany and the U.S.
Biohaven Pharma Holding Company Ltd.	troriluzole	Alzheimer’s disease	Phase 2/3 trial initiated enrolling subjects with mild to moderate Alzheimer’s disease
CymaBay Therapeutics, Inc.	seladelpar	Primary Biliary Cholangitis (PBC)	Phase 3 trial initiated enrolling 240 subjects in over 20 countries
Revance Therapeutics, Inc.	DaxibotulinumtoxinA for Injection (DAXI)	isolated cervical dystonia (CD)	Phase 3 trial initiated enrolling 301 subjects at 60 sites in the U.S., Canada and Europe
EpicentRX, Inc.	RRx-001	small cell lung cancer	Phase 3 trial initiated enrolling 126 subjects with third-line and beyond small cell lung cancer
Okami Medical Inc.	LOBO Vascular Occlusion System	occlusion of peripheral blood vessels	510(k) approval granted by the FDA
Autolus Therapeutics plc	AUTO1	acute lymphoblastic leukemia (ALL)	Orphan drug designation granted by the FDA
Sanofi	Fluzone High-Dose Quadrivalent (Influenza Vaccine)	prevention of influenza disease caused by influenza A and B strains contained in the vaccine in subjects 65 years of age and older	sBLA approval granted by the FDA
RedHill Biopharma Ltd.	Talicia (omeprazole magnesium, amoxicillin and rifabutin) delayed-release capsules 10 mg1/250 mg/12.5 mg	Helicobacter pylori (H. pylori) infection in adults	Approval granted by the FDA
GE Healthcare	Clariscan	intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity	Approval granted by the FDA
Crescita Therapeutics Inc.	Pliaglis (enhanced formulation)	superficial dermatological procedures	Approval granted by the FDA
Sandoz	Ziextenzo (pegfilgrastim)	infection in cancer patients	Approval granted by the FDA